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    Epithelial Disorders # 3

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    Eshal Muzaffar
    This document summarizes various epithelial disorders discussed in Lecture 3 by Dr. Faiqa Yasser. It describes epithelial hyperplasia conditions like hyperkeratosis, smoker's keratosis, acanthosis, and pseudoepitheliomatous hyperplasia. It also discusses nicotine stomatitis, proliferative verrucous leukoplakia, their clinical features and histopathology. Treatment may involve quitting smoking, surgical excision or laser therapy depending on the condition.

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    Epithelial Disorders # 3

    Uploaded by

    Eshal Muzaffar
    13 views32 pages
    This document summarizes various epithelial disorders discussed in Lecture 3 by Dr. Faiqa Yasser. It describes epithelial hyperplasia conditions like hyperkeratosis, smoker's keratosis, acanthosis, and pseudoepitheliomatous hyperplasia. It also discusses nicotine stomatitis, proliferative verrucous leukoplakia, their clinical features and histopathology. Treatment may involve quitting smoking, surgical excision or laser therapy depending on the condition.

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    EPITHELIAL DISORDERS # 3

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    This document summarizes various epithelial disorders discussed in Lecture 3 by Dr. Faiqa Yasser. It describes epithelial hyperplasia conditions like hyperkeratosis, smoker's keratosis, acanthosis, and pseudoepitheliomatous hyperplasia. It also discusses nicotine stomatitis, proliferative verrucous leukoplakia, their clinical features and histopathology. Treatment may involve quitting smoking, surgical excision or laser therapy depending on the condition.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    13 views32 pages

    Epithelial Disorders # 3

    Uploaded by

    Eshal Muzaffar
    This document summarizes various epithelial disorders discussed in Lecture 3 by Dr. Faiqa Yasser. It describes epithelial hyperplasia conditions like hyperkeratosis, smoker's keratosis, acanthosis, and pseudoepitheliomatous hyperplasia. It also discusses nicotine stomatitis, proliferative verrucous leukoplakia, their clinical features and histopathology. Treatment may involve quitting smoking, surgical excision or laser therapy depending on the condition.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 32

    EPITHELIAL DISORDERS

    LECTURE 3
    DR FAIQA YASSER
    Associate professor
    EPITHELIAL HYPERPLASIA
     HYPERKERATOSIS

     Excessively thickened layer of stratum


    corneum
     It can be:
     HYPERORTHOKERATOSIS
     HYPERPARAKERATOSIS
    CONTD…
     On histopathologic examination the majority of
    leukoplakias are either orthokeratosis or
    hyperparakeratosis
     Keratins functions as a protective barrier on
    skin or mucous membranes
     Various stimuli like chronic frictional irritation
    caused by ill fitting dentures can cause it
     Smoking and use of smokeless tobacco
    SMOKER’S KERATOSIS

     Hyperorthokeratosis
     Hyperparakeratosis
     It is induced by :
     Cigarette
     Cigar
     Pipe smoking
     Clinically it appears as a series of slightly
    elevated white striations on the labial mucosa
     Histopathologically it exhibits characteristic
    chevron or church spire organization of the
    parakeratin
    ACANTHOSIS
     It is defined as :
     Excessive thickening of the spinous layer of
    squamous epithelium resulting in broadening
    and elongation of the rete pegs
     It is a benign hyperplasia of squamous
    epithelium
    CLINICAL PRESENTATION
     Clinically seen as an area of leukoplakia
     Can occur alone or with hyperkeratosis
     Develops in response to chronic irritants like
     ill fitting dentures
     Smoking
     Tobacco chewing
     Infections such as chronic candidiasis
    PSEUDOEPITHELIOMATOUS
    HYPERPLASIA

     An excessive but benign proliferation of


    squamous epithelium that histologically
    resembles the proliferation seen in a squamous
    cell carcinoma
    ORAL CONDITIONS
     In which pseudoepitheliomatous hyperplasia is
    seen :

     Inflammatory papillary hyperplasia


     Chronic hyperplastic candidiasis
     Granular cell tumor
     Blastomycosis
    NICOTINE STOMATITIS
     It is a :
     Diffuse white change of the palate , the buccal
    mucosa, or both caused by combination of
    hyperkeratosis and acanthosis, frequently
    exhibiting multiple small dimpled nodules
    around moinor salivary gland duct openings
    found primarily in chronic pipe smokers .
     Rarely seen in cigar or cigarette smokers
    CLINICAL FEATURES
     Palate is whiter than normal
     Multiple small circular papules with tiny
    umbilicated red centers on hard palate
     May be seen on buccal mucosa
     Usually the same side where pipe is mostly
    held
    HISTOPATHOLOGY
     Hyperkeratosis
     Acanthosis
     Dilated salivary gland duct exhibiting
    squamous metaplasia of the ductal lining
     Connective tissue adjacent to salivary gland
    duct reveals chronic inflammation
    TREATMENT
     Quit smoking

     Pre malignant ?
    PROLIFERATIVE VERRUCOUS
    LEKOPLAKIA (PVL)

    It is presented as :
    Diffuse white and / or papillary (“warty”) areas
    of the oral mucosa resulting from varying degrees
    of epithelial hyperplasia; has the potential to
    develop into verrocous carcinoma or well
    differentiated squamous cell carcinoma. Also
    known as verrucous hyperplasia
    CLINICAL FEATURES
     Primarily occurs in older patients
     Strong predilection for females
     Female to male ratio is 4:1
     Clinical course of PVL is relatively slow
     It has relentless progression to SCC
     Cause of this progression to malignancy is
    unknown
    HISTOPATHOLOGY

     Hyperkeratosis
     Verrucous keratosis
     Verrucous carcinoma
     Squamous cell carcinoma
    TREATMENT
     Surgical excision for smaller size lesion
     If the entire arch or both arches are involved
    then treatment become more difficult
     We have to preserve vital anatomical structure
     In maxilla involvement of soft palate uvula and
    tonsillar pillars can be problematic
     Laser therapy is helpful

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