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    Oxamniquine

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    Mtw Wond
    Oxamniquine is an alternative treatment to praziquantel for Schistosoma mansoni infections. It is effective against both mature and immature stages of S. mansoni by causing contraction and paralysis of the worms. It has been used for mass treatment and can be effective against praziquantel-resistant strains. It is absorbed orally but is not effective against S. haematobium or S. japonicum.

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    Oxamniquine

    Uploaded by

    Mtw Wond
    34 views7 pages
    Oxamniquine is an alternative treatment to praziquantel for Schistosoma mansoni infections. It is effective against both mature and immature stages of S. mansoni by causing contraction and paralysis of the worms. It has been used for mass treatment and can be effective against praziquantel-resistant strains. It is absorbed orally but is not effective against S. haematobium or S. japonicum.

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    Oxamniquine is an alternative treatment to praziquantel for Schistosoma mansoni infections. It is effective against both mature and immature stages of S. mansoni by causing contraction and paralysis of the worms. It has been used for mass treatment and can be effective against praziquantel-resistant strains. It is absorbed orally but is not effective against S. haematobium or S. japonicum.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    34 views7 pages

    Oxamniquine

    Uploaded by

    Mtw Wond
    Oxamniquine is an alternative treatment to praziquantel for Schistosoma mansoni infections. It is effective against both mature and immature stages of S. mansoni by causing contraction and paralysis of the worms. It has been used for mass treatment and can be effective against praziquantel-resistant strains. It is absorbed orally but is not effective against S. haematobium or S. japonicum.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
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    OXAMNIQUINE

    • Oxamniquine is an alternative to praziquantel for the treatment of S


    mansoni infections.
    • It has also been used extensively for mass treatment.
    • It is not effective against S haematobium or S japonicum.
    Anthelmintic Actions
    • Oxamniquine is active against both mature and immature stages of S
    mansoni but does not appear to be cercaricidal.
    • The mechanism of action is unknown.
    • Contraction and paralysis of the worms results in detachment from
    terminal venules in the mesentery and transit to the liver.
    • Oxamniquine has been effective in instances of praziquantel resistance.
    Clinical Uses
    • safe and effective in all stages of S mansoni disease, including
    advanced hepatosplenomegaly.
    • results disappearance of acute symptoms and clearance of the
    infection in treatment of acute (Katayama) syndrome.
    • used in combination with metrifonate for mixed schistosome
    infections
    • Optimal dosage schedules vary for different regions of the world.
    • less effective in children
    • better-tolerated with food.
    Pharmacokinetics
    • Oxamniquine is readily absorbed orally.
    • Its plasma half-life is about 2.5 hours.
    • The drug is extensively metabolized to inactive metabolites and
    excreted in the urine up to 75% in the first 24 hours.
    • Intersubject variations in serum concentration have been noted,
    which may explain some treatment failures.
    Adverse Reactions
    • Central nervous system symptoms (dizziness, headache, drowsiness)
    are most common.
    • Nausea and vomiting, diarrhea, colic, pruritus, and urticaria also occur
    Infrequently
    • May cause low-grade fever, an orange to red discoloration of the
    urine, proteinuria, microscopic hematuria, and a transient decrease in
    leukocytes.
    • Seizures have been reported rarely.
    Contraindications
    • Since the drug makes many patients dizzy or drowsy, it should be used
    with caution in patients whose work or activity requires mental
    alertness.
    • should be used with caution in those with a history of epilepsy.
    • contraindicated in pregnancy
    Doxycycline
    • tetracyclic antibiotic agent
    • has recently been shown to have significant macrofilaricidal activity
    against W bancrofti
    • has activity against onchocerciasis.
    • Doxycycline with ivermectin has complementary therapy for the
    control of onchocerciasis.
    • Can reduce the transmission and occurrence of onchocercal eye
    disease.

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