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    Trypsin Chymotrypsin

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    Kalpana Shubhangi Bheda
    Trypsin:chymotrypsin is an oral proteolytic enzyme combination that facilitates tissue repair through several mechanisms. It shows high bioavailability and maintains its anti-inflammatory, anti-edematous, fibrinolytic, and anti-infective properties to help resolve signs of inflammation and facilitate the repair process. Specifically, it targets the early inflammatory stage by ensuring plasmin remains available for fibrinolysis and restoring microcirculation. Additionally, it helps maintain high levels of α1-antitrypsin to counter proteolytic enzymes and reduce oxidative stress, further aiding the healing process.

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    Trypsin Chymotrypsin

    Uploaded by

    Kalpana Shubhangi Bheda
    53 views6 pages
    Trypsin:chymotrypsin is an oral proteolytic enzyme combination that facilitates tissue repair through several mechanisms. It shows high bioavailability and maintains its anti-inflammatory, anti-edematous, fibrinolytic, and anti-infective properties to help resolve signs of inflammation and facilitate the repair process. Specifically, it targets the early inflammatory stage by ensuring plasmin remains available for fibrinolysis and restoring microcirculation. Additionally, it helps maintain high levels of α1-antitrypsin to counter proteolytic enzymes and reduce oxidative stress, further aiding the healing process.

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    Trypsin:chymotrypsin is an oral proteolytic enzyme combination that facilitates tissue repair through several mechanisms. It shows high bioavailability and maintains its anti-inflammatory, anti-edematous, fibrinolytic, and anti-infective properties to help resolve signs of inflammation and facilitate the repair process. Specifically, it targets the early inflammatory stage by ensuring plasmin remains available for fibrinolysis and restoring microcirculation. Additionally, it helps maintain high levels of α1-antitrypsin to counter proteolytic enzymes and reduce oxidative stress, further aiding the healing process.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    53 views6 pages

    Trypsin Chymotrypsin

    Uploaded by

    Kalpana Shubhangi Bheda
    Trypsin:chymotrypsin is an oral proteolytic enzyme combination that facilitates tissue repair through several mechanisms. It shows high bioavailability and maintains its anti-inflammatory, anti-edematous, fibrinolytic, and anti-infective properties to help resolve signs of inflammation and facilitate the repair process. Specifically, it targets the early inflammatory stage by ensuring plasmin remains available for fibrinolysis and restoring microcirculation. Additionally, it helps maintain high levels of α1-antitrypsin to counter proteolytic enzymes and reduce oxidative stress, further aiding the healing process.

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    © All Rights Reserved
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    Trypsin:Chymotrypsin

    Role of Trypsin:Chymotrypsin in Tissue


    Repair
    • Trypsin:chymotrypsin is a widely used oral proteolytic enzyme
    combination to hasten repair of traumatic, surgical, and orthopedic
    injuries.
    • It shows high bioavailability without losing its biological activities as
    an anti-inflammatory, anti-edematous, fibrinolytic, antioxidant, and
    anti-infective agent
    • These properties help in resolving signs and symptoms of
    inflammation due to tissue injury and facilitate the repair process.
    • It also demonstrates analgesic effects and reduces the pain associated
    with healing
    Ref: Shah D, Mital K. The Role of Trypsin:Chymotrypsin in Tissue Repair. Adv Ther. 2018 Jan;35(1):31-42. doi: 10.1007/s12325-017-0648-y. Epub 2017 Dec 5. PMID: 29209994; PMCID: PMC5778189.
    1. Chandanwale A, Langade D, Sonawane D, Gavai P. A randomized, clinical trial to evaluate efficacy and tolerability of trypsin:chymotrypsin as compared to serratiopeptidase and trypsin:bromelain:rutoside in wound
    management. Adv Ther. 2017;34:180–198. doi: 10.1007/s12325-016-0444-0.
    2. Apsangikar P, Naik M, Tike C. Analysis of an open multicentric study of the efficacy, safety and tolerability of Chymoral Forte in resolving signs and symptoms of inflammation in patients with traumatic injuries. Hospital Today.
    2005;10(1)
    3. Bruni M, Quarti Trevano GM, Baresi A, Bellinzoni G. A follow-up of the protein pattern after operations in patients treated with an oral enzyme. Arzneimittelforschung. 1980;30(11):1922–1925
    Mechanism 1
    • Oral combination of trypsin:chymotrypsin targets this early stage of
    inflammation.
    • Since α1-antitrypsin shows greater affinity for trypsin and
    chymotrypsin compared to plasmin, oral supplementation of the
    enzyme complex ensures that plasmin remains available for
    fibrinolysis and the period of fibrinolytic shutdown is shortened.
    • As a result, local microcirculation is restored, inflammatory edema is
    cleared, and tissue repair is facilitated
    Mechanism 2
    • trypsin:chymotrypsin helps in maintaining high levels of α1-
    antitrypsin for a long duration.
    • Consequently, the activity of proteolytic enzymes and their
    degradative effects are countered, leading to reduction in
    inflammatory milieu, ROS and oxidative stress, and faster healing.
    • Additionally, the enzyme preparation also increases enzymatic and
    non-enzymatic antioxidant levels, which further augments its
    antioxidant and anti-inflammatory efficacy

    1. Apsangikar P, Naik M, Tike C. Analysis of an open multicentric study of the efficacy, safety and tolerability of Chymoral Forte in resolving signs and symptoms of inflammation in patients with traumatic injuries. Hospital Today. 2005;10(1)
    2. Bruni M, Quarti Trevano GM, Baresi A, Bellinzoni G. A follow-up of the protein pattern after operations in patients treated with an oral enzyme. Arzneimittelforschung. 1980;30(11):1922–1925.
    Other Mechanisms
    • The anti-infective property of the enzyme complex may be explained
    by enhanced phagocytic activity of natural killer cells and
    macrophages due to trypsin1
    • The combination has been shown to reduce the constant loss of
    albumin and pre-albumin after surgical procedures2
    • Consequently, it may prevent many of the life-threatening
    postoperative complications, such as shock

    Ref:
    Chandanwale A, Langade D, Sonawane D, Gavai P. A randomized, clinical trial to evaluate efficacy and tolerability of trypsin:chymotrypsin as compared to serratiopeptidase and trypsin:bromelain:rutoside in wound management. Adv
    Ther. 2017;34:180–198. doi: 10.1007/s12325-016-0444-0.
    Bruni M, Quarti Trevano GM, Baresi A, Bellinzoni G. A follow-up of the protein pattern after operations in patients treated with an oral enzyme. Arzneimittelforschung. 1980;30(11):1922–1925.

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