Neck & Body Rejuvenation

NECK & BODY
REJUVENATION
dr.Kusumaningrum
INTRODUCTION
01 02 03
Neck and body’s skin Get more aged than the Still look older when
often forgotten to be face compare to treated your neck looks old.
treated. face.
Commonly reffrered as
‘turkeys’s neck”.
COMMON COSMETIC CONCERNS
OF THE NECK AND BODY
NECK :
1. Wrinkles. BODY :
2. Neck lines. 1. Stretch marks.
3. Skin laxity. 2. Skin laxity.
4. Double chin. 3. Cellulite.
5. Pigmentation. 4. Obesity.
INTRINSIC CHANGES DURING PHOTOAGING
Mollecullar Cell Research 2017 1864; 11. 2015-25

Aging
Composition of connective tissue
◦ Collagen approximately 70 – 80 % : tensile strength.

◦ Elastin 1 – 2 % of the dry weight of skin : skin elasticity, resilience
◦ Glycosaminoglycans 0,1 – 0,3 % : maintain water balance
◦ Fibroblasts
◦ Macrophages
◦ Ground substance
Connective tissue and aging A.Oikarinen International Journal of cosmetic science Volume 26. Issue 2 April 2004, pages 107.
Cox TR, Erler JT. Remodelling and homeostasis of the extracellular matrix implications for fibrotic diseases and cancer. Dis Model Mech. 2011.
Collagen molecule consists of three polypeptide alpha-
chains, with more than 1000 amino acids in each of them.
Multiplication
of fibroblasts
Decreasing a
speed of the Stimulation of
collagen collagen
degradation synthesis
AA
Production of
Chemotaxis growth factors
(TGFβ)
AMINO ACID
◦ 33,7 % are presented by glycine.

◦ 13,3 % by proline.
◦ 11,6 % by alanine.
◦ 9,7 % by hydroxyproline.
TO BUILD COLLAGEN WE NEED :
◦ 1. Adequacy of type and number of AA.

◦ 2. Presence in the precursor form ( for some type of AA), to
activate the syntethic drive by fibroblasts.
◦ 3. Continuous availability and presence of AA in specific ratio.
JOURNAL OF PLASTIC DERMATOLOGY 2007
Journal of Plastic Dermatology 2007; 3,3

SUMMARY
PURPOSE AND STUDY DESIGN
AIM OF THE STUDY:

clinical and instrumental evaluations the tolerance and the efficacy on aging face as a
biorevitalizer (intradermal injections + standard cosmetic treatment + food supplement)
VOLUNTEERS:
113 females (35-60 y.o.) with low-moderate skin ageing/photoaging
PROTOCOL:
▪ 22 weeks
▪ 4 intradermal implants with the injectable study product were performed
▪ 3 visits (at baseline (T0), 1 month after the last intradermal implant (T1) and 4 months
after the last intradermal implant (T4)): clinical assessment, skin replicas (at the level of
nasolabial folds left or right randomly), photographic documentation (frontal and profile
pictures)
PHOTOGRAPHIC DOCUMENTATION
Volunteer n. 1
Naso Labial Folds Replicas
BASAL (T0) T1 INTERMEDIATE VISIT T4 FINAL VISIT T6 ADDITIONAL VISIT

(1 month after the last intradermal (4 months after the last intradermal (6 months-2 months after the
implant) implant) additional intradermal implant)
Volunteer n. 19

Volunteer n. 20

MORPHOLOGICAL AND FUNCTIONAL CHANGES OF THE
SKIN AFTER AMINOACID REPLACEMENT THERAPY
RESULTS
INDICATIONS
JALUPRO CLASSIC JALUPRO HMW
▪ Photo-aging and anti-aging of face and ▪ Photo-aging and anti-aging of a face and a
body (light and medium degree). body (moderate and severe degree).
▪ Stretch marks, scars. ▪ Dry and dehydrated skin.
▪ Preparation, improvement and ▪ Procedures during summer time.

prolongation of results for different
aesthetic procedures (fillers, ▪
The beginning of the course of revitalization.
peelings,lasers).
▪ Preparation, improvement and prolongation

▪ PRE & POST surgery.
of results for different aesthetic procedures.
LMW HA COMPARE WITH HMW HA
JALUPRO JALUPRO HMW

1% Sodium hyaluronate 2% Sodium hyaluronate
180-200 kDa 1400-1600 kDa
▪ Fast dermal hydration. ▪ Attracts fibroblasts (a cumulative effect with AA).

▪ Active transport of amino acid cluster. ▪ Long lasting hydration => long stimulation of
▪ Stimulation of proliferation, differentiation and different HA receptors => stimulation of fibroblast
activity (cumulative effect with AA).
cell migration (a cumulative effect of an amino
acid cluster). ▪ Higher viscosity => less degradation by hyaluronidase
▪ Activation of the repair processes. => long lasting result.
▪ Product exists in dermis more than 15 days =>
▪ A strong antioxidant effect.
recommended for aged skin where all metabolic
processes are less active.
▪ Long lasting stimulation of CD44 =>
maintaining homeostasis, providing regeneration, part
icipation in the process of apoptosis.
JALUPRO CLASSIC
2 AMPOULES
Freeze dried Amino Acids (100mg) 2 VIALS

▪ Glycine 50 mg
▪ L-Proline 37.6 mg 1 % Sodium hyaluronate 200
▪ L-Lysine 5.4 mg kDa . @ 3 ml
▪ L-Leucine 7 mg
31
JALUPRO HMW (CE Marked - III class Medical Device)
1 AMPOULE
Water solution of Amino Acids (80mg) – 1 ml
▪ Glycine 40 mg
▪ L-Proline 30.08 mg
▪ L-Lysine 4.32 mg
▪ L-Leucine 5.6 mg
1 VIALS
2 % Sodium hyaluronate 1400-1600 kDa – 1,5 ml
INTRADERMAL INJECTIONS: WHERE AND WHY?
DERMIS:
▪ Papillary dermis (relaxed fibrillary network): collagen fibers of

small diameter, immature elastic fibers
▪ Reticular dermis (dense fibrillary network): collagen fibers,

mature elastic fibers, abundant fibroblasts with a great
proliferative potential and a strong metabolic activity
Intradermal injections produce papules, which cause pain due to
overstretching of epidermal skin layers and acidity of the product:
- Inject smaller amount of product per injection
- Start injecting from the right side of the face (in 90% of people
manipulations on the left side of face and body are more painful)
PRACTICAL RECOMMENDATIONS: FACE
HYALU-BOTOX
PRODUCT VOLUME VOLUME
Free HA (HA vial from Jalupro) 1 ml 3 ml
Botulinum toxin type A (100Ux2,5 ml) 10 U 30 U
Amino acids lyophilized 1 vial 1 vial

=
Do at least 3 months intervals between Jalubotox treatments
▪ First session: Jalubotox
▪ After 10 days Jalupro 1ml +vial of AA
▪ After 10 days Jalupro 1ml+ vial of AA

RESULTS
▪ Activation of a metabolic processes
▪ Restoring the normal structure of the dermis
▪ Improving and support the nutrition of the tissue
▪ Physiological rejuvenation of collagen structure in the area of injection
Thank you
dr.kusumaningrum77@gmail.com

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NECK & BODY

Mollecullar Cell Research 2017 1864; 11. 2015-25

◦ Collagen approximately 70 – 80 % : tensile strength.

◦ 33,7 % are presented by glycine.

◦ 1. Adequacy of type and number of AA.

Journal of Plastic Dermatology 2007; 3,3

AIM OF THE STUDY:

BASAL (T0) T1 INTERMEDIATE VISIT T4 FINAL VISIT T6 ADDITIONAL VISIT

BASAL (T0) T1 INTERMEDIATE VISIT T4 FINAL VISIT T6 ADDITIONAL VISIT

BASAL (T0) T1 INTERMEDIATE VISIT T4 FINAL VISIT T6 ADDITIONAL VISIT

▪ Stretch marks, scars. ▪ Dry and dehydrated skin.

▪ Preparation, improvement and ▪ Procedures during summer time.

▪ Preparation, improvement and prolongation

JALUPRO JALUPRO HMW

▪ Fast dermal hydration. ▪ Attracts fibroblasts (a cumulative effect with AA).

Freeze dried Amino Acids (100mg) 2 VIALS

▪ Papillary dermis (relaxed fibrillary network): collagen fibers of

▪ Reticular dermis (dense fibrillary network): collagen fibers,

Free HA (HA vial from Jalupro) 1 ml 3 ml

Botulinum toxin type A (100Ux2,5 ml) 10 U 30 U

Amino acids lyophilized 1 vial 1 vial

▪ After 10 days Jalupro 1ml +vial of AA

▪ After 10 days Jalupro 1ml+ vial of AA

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