OSSEOINTEGRATION

Contents
Introduction
Definition
Bone density classification
Biological considerations for
osseointegration
 Bone implant interface
 Bone remodeling
 Foreign body reaction
…
 Bone to implant interface
 Mechanism of osseointegration
 Ultrastructure in osseointegration
 Destruction of osseointegration
 Soft tissue implant interface
 Peri-implant membrane
 Disease activity in peri-implant tissue
 Neuromuscular system as it relates to the implant
….

Factors influencing osseointegration

Osseointegration vs biointegration
Success criteria for osseointegrated implants
Clinical applications of osseointegration
Future of osseointegration
Summary & Conclusion
References
 Introduction

The ideal goal of modern dentistry is to restore the

patient to normal contour, function………..

Implant dentistry is unique because of its ability to

achieve this goal regardless of the stomatognathic
system.
…..

The primary function of an implant is to act as an

abutment for prosthetic device.

The present surge in the use of implants was

initiated by Branemark (1952)………..

Described the relationship between titanium and

bone for which they coined the term

osseointegration.
 Definition
The word osseointegration consists of “OS” the
Latin word for bone and “integration” derived
from Latin word meaning the state of being
combined into a complete whole.

Osseointegration is defined as a direct bone

anchorage to an implant body which can provide
a foundation to support a prosthesis.
 “Direct structural and functional connection

between ordered, living bone and surface of a

load carrying implant”.

…..

American Academy of Implant Dentistry

defined it as “contact established

without interposition of non bone tissue

between normal remodeled bone and on

implant entailing a sustained transfer

and distribution of load from the

implant to and within bone tissue”.

Initial concept of osseointegration stemmed
from vital microscopic studies of
microcirculation in bone repair mechanisms.
Titanium chamber was surgically inserted
into the tibia of of a rabbit.
It was considered the best material for
artificial tooth root replacement.
…..
Many studies followed involving titanium
implants being placed into jaws of dogs.
Direct bone anchorage has been shown to
be very strong. A force of over 100kg was
applied to dislodge an implant.
Based on such a consequence the
foundation for Osseo integration and the
Branemark implant system was established
in 1952.
Studies on humans were

conducted by means of an

implant optical titanium chamber

in a twin pedicle skin tube on the

inside of the left upper arm of

volunteers.

Tissue reactions were studied in

long term experiments.

All this lead to the treatment of

first edentulous patient in 1965.

History of Branemark system categorized in
three stages
 Early stage (1965-1968)

 Developmental stage (1968-1971)

 Production stage (1971 – present)

Bone density classification (Misch)
 Biological Considerations for
Osseointegration
Bone implant interface
 When compared to compact bone
spongy bone has less density and
hardness is not a stable base for
primary fixture fixation.
 In the mandible the spongy bone
is more dense than maxilla.
 With primary fixation in
compact bone, osseointegration
in the maxilla require a longer
healing period.
Bone remodeling
Osseointegration requires new bone formation
around the fixture. A process resulting from
remodeling within bone tissue.
Osteoblastic and osteoclastic activity helps
maintain blood calcium without change in
quantity of bone.
…..
To maintain a constant level of bone
remodeling there should be proper local
stimulation, crucial levels of thyroid
hormone, calcitonin and vitamin D.
Occlusion or occlusal force stimulus are
both important to optimal bone remodeling.
Foreign body reaction

Organization or an antigen antibody

reaction occurs when a foreign body is

present in the body.

This reaction occurs in the presence of a

protein but with implant materials devoid

of proteins no antigen antibody reaction.

…..

When titanium is used no foreign body reaction are

seen.

The implant material is an important factor for

Osseo integration to occur.

Bone to implant interface
Two basic theories
 Fibro-osseous integration by Linkow, James & Weis
 Osseointegration by Branemark

 Meffert divided osseointegration

Adaptive osseointegration Biointegration

American Academy of implant dentistry defined

fibrous integration as tissue to implant contact with

healthy dense collagenous tissue between the

implant and bone.

…..
The fibers are arranged irregularly, parallel to the

implant body, when forces are applied they are not

transmitted through the fibers.

So no bone remodeling expected in fibro-

integration.
A direct bone implant interface occurs when an
implant is allowed to heal in bone undisturbed.

Main factors affecting osseointegration include

 Implant oxide layer contamination.
 Poor temperature control during drilling.
……

A minimum of 3 month healing in mandible and 6

months in maxilla is necessary before load is
applied.
If osseointegration does not occur or a fibrous
connective tissue forms around the implant
organization process continues.
Biological process of implant osseointegration

The healing process of implant

system is similar to primary
bone healing.
Titanium dental implants show
three stages of healing.
…..

OSTEOPHYLLIC STAGE
 When a implant is placed into the cancellous marrow
space blood is initially present between implant and
bone.
 Only a small amount of bone is in contact with the
implant surface; the rest is exposed to extracellular
fluids.
 Generalized inflammatory response to the surgical
insult.
…..
 By the end of first week, inflammatory cells are
responding to foreign antigens.
 Vascular ingrowth from the surrounding vital tissues
begins by third day.
 A mature vascular network forms by 3 weeks.
 Ossification also begins during the first week and the
initial response observed in the migration of osteoblasts
from the trabacular bone which can be due to the
release of BMP’s.
 The osteophyllic phase lasts about 1 month.
OSTEOCONDUCTIVE PHASE
Once they reach the implant, the bone cells spread
along the metal surface laying down osteoid.

Initially this is an immature connective tissue

matrix and bone deposited is a thin layer of woven
bone called foot plate.
…..
 Fibro-cartilaginous callus is eventually
remodeled into bone callus.
 This process occurs during the next 3 months
 Four months after implant placement the
maximum surface area is covered by bone.
OSTEOADAPTIVE PHASE
 The final phase begins approximately 4 months after
implant placement.
 Once loaded implants do not gain or loose bone contact but
the foot plates thicken in response and some reorientation of
the vascular pattern may be seen.
…..
 Grafted bone integrates to a higher degree than the
natural host bone to the implant.
 To achieve optimal results an osseointegration period
of 4 months is recommended for implants in graft
bone and 4 to 8 months for implant placed in normal
bone.
 Ultrastructure in osseointegration

 Osseointegrated fixtures
under occlusal loads are
surrounded by cortical and
spongy bone.

 The cortical bone to fixture

surface interface has
canaliculi participating in
electrolyte transportation
near oxide layer.
….

Osseointegration in spongy bone occurs as

bone trabaculae approaches the fixture and
come into intimate contact with oxide layer.
Ground substance forms and fills spaces
between bone trabeculae this fuses with
oxide layer.
 Destruction of Osseointegration
The main contributing factor to bone resorption are
local inflammation from plaque and trauma from
occlusion
 Direct action of plaque products induces formation of
osteoclasts.
 Plaque products at directly on bone destroying it
through a non cellular mechanism.
 Stimulate gingival cells, which release mediators for
osteoclast formation.
 Plaque causes gingival cells to release agents which act as
cofactors in bone resorption and which destroy bone by
direct chemical action without osteoclasts.
Bone resorption can be caused by premature
loading.
12 months following fixture insertion vertical
bone loss is observed due to traumatic
surgical procedure.
 Vertical bone loss approximately 1 to 1.5 mm in first year
 Marginal bone loss is 0.05 to 0.1 mm in first year
 These measurements can be used a reference and in a
bone loss condition should be evaluated to minimize
failure.
 Peri-implant membrane

 With the osseointegrated implant

the abutment to fixture junction
corresponds to cementoenamel
junction present in natural
dentition.
 Peri-implant membrane is similar
to that present in natural
dentition, consisting of peri-
implant free gingiva.
….

The sulcular epithelium forms the peri-

implant gingival crevice and junctional
epithelium attaches to the abutment forming
a cuff.

With a tight cuff and filamentous attachment

a membrane is sealed tightly and
functionally to the abutment surface.
 Disease activity in peri-implant tissue

The fibrous connective tissue capsule

formed around an implant generally has low
differentiating capabilities such that it also
has less resistance against bacterial bi-
products and does not respond well to
occlusal stimulation.

An osseointegrated implant has periosteum

directly covering the neck of the fixture.
Which may act as a barrier against
inflammation.
….

Although the abutment to junctional epithelium

attachment is not strong, a connective tissue band
is tightly attached to the abutment surface and acts
as resistant barrier.
 The neuromuscular system as it
relates to the osseointegrated
implant
A fixture site does not have periodontal ligament but
has nerve endings located near the fixture, sensing
pain and temperature.
Patients with osseointegrated implants have a high
threshold and low sensitivity for discriminating
thickness.
…..

As the periodontal ligament is lost the

fixture remains with reduce amount of
receptors.
Impulses from the fixture sites are
transmitted through motor nucleus of
trigeminal nerve.
 Mechanical retention

metallic substrate system such as titanium

or titanium alloy.

The retention is based on undercut forms

such as vents, slots, dimples, screws etc.,

Direct contact between the dioxide layer on

the titanium and bone with no chemical
bonding.
 Bioactive retention

Bioactivity
 characteristic of an implant material that allows attachment to
living tissues, whereas a non bioactive material would form a
loosely adherent layer of fibrous tissue at the implant interface

Bioactive retention is achieved with

bioactive materials such as hydroxyapatite

(HA), which bond directly to bone

 Plasma spraying & ion sputter coating

Two techniques used to coat metallic

implants with HA.
 Plasma spraying

Involves heating the HA by a plasma flame

at a temperature of approximately 15,000° C

to 20,000°C.

The HA is then propelled onto the implant

body in an inert environment like argon, to a

thickness of 50 to 100 μm.

 Ion-sputter coating

Process by which a thin, dense layer of HA can be

coated onto an implant substrate.

Directing an ion beam at a solid-phase HA block,

Vaporising it to create a plasma and then

recondensing this plasma on the implant.

Bone formation and maturation occurs at a faster

rate in the initial phases on HA coated implants
than on non-coated implants
 Advantages of increased surface
roughness of Cp Ti implant

Increased surface area of the implant adjacent to

bone.

Improved cell attachment to the implant surface.

Increased bone present at the implant surface.

Increased biomechanical interactions of the implant

with bone.

Promoted inflammation of the periimplant area.

 Clinical advantages of TPS or HA
coatings

Increased surface area

Increased roughness for initial stability

Stronger bone-to- implant interface

Additional advantages of HA over TPS include the

following

 Faster healing bone interface

 Increased gap healing between bone and HA

 Stronger interface than TPS

 Less corrosion of metal

 Disadvantages of Coatings

Flaking, cracking, or scaling upon insertion

Increased plaque retention when placed above the

bone.

Increased bacteria adhesion and acts as a nidus for

infection

Complications of treating the failing implants

Increased cost
 Factors influencing Osseointegration

 Biomaterial for dental implant

 Surface composition and structure
 Implant design
 Heat
 Contamination
 Primary stability or initial stability
 Bone quality
 Epithelial down growth
 Loading
1.Biomaterial for dental
implant

Implants must not induce a host immune

response Titanium and certain calcium-
phosphate ceramics are biocompatible
and do not stimulate a foreign body
rejection reaction.
2. Surface composition and
structure
 It is thought that cp Ti owes its ability to form an
osseointegrated interface to the tough and relatively inert
oxide layer, which forms very rapidly on its surface.
 This surface has been described as osseoconductive, that
is, conducive to bone formation
 Other substrates also have this property and may also
stimulate bone formation, a property known as
osseoinduction
3. Implant Design

The vast majority of commercially available

implants claiming osseointegration status
are cylindrical in shape.

Their design may be threaded or else lack

similar microscopic retentive/stabilization
aspects
4. Heat
Heating of bone to a temperature in
excess of 47°C during implant surgery can
result in cell death and denaturation of
collagen.
As a result, osseointegration may not
occur, instead the implant becomes
surrounded by a fibrous capsule and the
shear strength of the implant-host
interface is significantly reduced.
5. Contamination
 Contamination of the implant site by organic and inorganic
debris can prejudice the achievement of osseointegration.

 Material such as necrotic tissue, bacteria, chemical reagents

and debris from drills can all be harmful in this respect.
6. Primary stability or Initial
stability

 It is known that where an implant fits tightly into its

osteotomy site then osseointegration is more likely to
occur.
 This is often referred to as primary stability, and where
an implant body has this attribute when first placed
failure is less probable.
 This property is related to the quality of fit of the
implant, its shape, and bone morphology and density.
7. Bone quality

It is a function of bone density, anatomy and volume, and

has been described using a number of indices.
 The classifications of Lekholm & Zarb and of Cawood &
Howell are widely used to describe bone quality and
quantity.
 The former relates to the thickness and density of cortical
and Cancellous bone,
 and the latter to the amount of bone resorption.
 Bone volume does not by itself influence osseointegration,
but is an important determinant of implant placement
8. Epithelial down growth
 Early implant designs were often associated with down
growth of oral epithelium, which eventually exteriorized
the device.
 When the newer generation of cp Ti devices was
introduced great care was taken to prevent this by
initially covering the implant body with oral mucosa
while osseointegration occurred.
 The implant body was then exposed and a superstructure
added, since it was known that the osseointegrated
interface was resistant to epithelial down growth.
9. Loading schemes
 Delayed loading: The prosthesis is attached at the
second procedure after a conventional healing
period of 3 to 6 months 8, 23.
 Early loading: The prosthesis is attached during a
second procedure, earlier than the conventional
healing period of 3 to 6 months. Time of loading
should be stated in days to weeks 8, 23.
 Immediate / Direct loading: The prosthesis is
attached to the implants the same day the implants
are placed.
 Success criteria for Osseo integrated
Implants
 Durability
 Bone loss
 Gingival health
 Pocket depth
 Effect of adjacent teeth
 Functions
 Esthetics
 Presence of infection
 Intrusion on the mandibular canal
 Patient emotional and psychological attitude
 Revised criteria for implant success

 Individual unattached implant is immobile when

tested clinically.
 No evidence of peri implant radiolucency is present as
assessed on an undistorted radiograph.
 Mean vertical bone loss is less than 0.2 mm after 1st
year of service.
 No persistent pain, discomfort or infection.
 A success rate of 85% at the end of a 5-year
observation period and 80% at the end of a 10-year
period are minimum levels of success.
 Futuristic concepts of Osseointegration

OSSEOPERCEPTION
 The interaction between
the osseointegrated
fixture bone tissue,
receptor systems and
nervous system has to be
studied.
“Owing to the nature of osseointegration it is
not easy to dissect the system of anchorage
from the clinical level down to the molecular
level or even the real interface which is still
largely a mystery”
Summary
 Mechanism of Osseointegration
Blood clot (between fixture & bone)

Clot transformed by phagocytic cell

(1st to 3rd day)

Procallus formation
(containing fibroblasts & phagocytes)

Procallus becomes dense connective tissue

(Differentiation of osteoblasts & fibroblasts)

Callus (Osteoblasts on the fixture)

Fibro cartilagenous callus (between fixture & bone)

Bone callus (Penetrates & matures)

Prosthesis attached to the fixtures stimulating bone remodeling

 References
 Hobo, Ichida, Garcia “Osseointegration and occlusal
rehabilitation” Quintessence Publishing.
 Jan Lindhe “Clinical periodontology and implant
dentistry” 4th edition, Blackwell Publishing.
 Elaine McClarence “Branemark and the development of
osseointegration” Quintessence publication
 Carl E. Misch “Implant dentistry” 2nd edition, Mosby.
 Hubertus Spiekermann “Color atlas of dental medicine
implantology” Theime Publishers.