Diabetic Ketoacidosis (Redirected From)

Diabetic Ketoacidosis (redirected from Diabetic ketosis)
Diabetic ketoacidosis (DKA) always results from a severe insulin deficiency. Insulin is the hormone secreted by the body to lower the blood sugar levels when they become too high. Diabetes mellitus is the disease resulting from the inability of the body to produce or respond properly to insulin, required by the body to convert glucose to energy. In childhood diabetes, DKA complications represent the leading cause of death, mostly due to the accumulation of abnormally large amounts of fluid in the brain (cerebral edema). DKA combines three major features: hyperglycemia, meaning excessively high blood sugar kevels; hyperketonemia, meaning an overproduction of ketones by the body; and acidosis, meaning that the blood has become too acidic.
Insulin deficiency is responsible for all three conditions: the body glucose goes largely unused since most cells are unable to transport glucose into the cell without the presence of insulin; this condition makes the body use stored fat as an alternative source instead of the unavailable glucose for energy, a process that produces acidic ketones, which build up because they require insulin to be broken down. The presence of excess ketones in the bloodstream in turn causes the blood to become more acidic than the body tissues, which creates a toxic condition.
Causes and symptoms

DKA is most commonly seen in individuals with type I diabetes, under 19 years of age and is usually caused by the interruption of their insulin treatment or by acute infection or trauma. A small number of people with type II diabetes also experience ketoacidosis, but this is rare given the fact that type II diabetics still produce some insulin naturally. When DKA occurs in type II patients, it is usually caused by a decrease in food intake and an increased insulin deficiency due to hyperglycemia.
Some common DKA symptoms include: high blood sugar levels frequent urination (polyuria) and thirst fatigue and lethargy nausea vomiting abdominal pain fruity odor to breath rapid, deep breathing muscle stiffness or aching coma
Diagnosis
Diagnosis requires the demonstration of hyperglycemia, hyperketonemia, and acidosis. DKA is established if the patient's urine or blood is strongly positive for glucose and ketones. Normal glucose levels in a non-diabetic person on average range from 80-110 mg/dl. A person with diabetes will typically fluctuate outside those parameters. DKA glucose levels exceed 250 mg/dl and can reach 400 to 800 mg/dL. A low serum bicarbonate level (usually below 15 mEq/L) is also present, indicative of acidosis. A blood test or urinalysis can quickly determine the concentration of glucose in the bloodstream. Test strips are available to patients commercially can submerge in urine to detect the presence or concentration of ketones.
Treatment
Ketoacidosis is treated under medical supervision and usually in a hospital setting. Basic treatment includes: administering insulin to correct the hyperglycemia and hyperketonemia replacing fluids lost through excessive urination and vomiting intravenously balancing electrolytes to re-establish the chemical equilibrium of the blood and prevent potassium deficiency (hypokalemia) during treatment treatment for any associated bacterial infection
Prevention
Once diabetes has been diagnosed, prevention measures to avoid DKA include regular monitoring of blood glucose, administration of insulin, and lifestyle maintenance. Glucose monitoring is especially important during periods of stress, infection, and trauma when glucose concentrations typically increase as a response to these situations. Ketone tests should also be performed during these periods or when glucose is elevated.
Lactic Acidosis
Lactic acidosis results from overproduction of lactate, decreased metabolism of lactate, or both. Lactate is a normal byproduct of glucose and amino acid metabolism. The most serious form of lactic acidosis, type A, occurs when lactic acid is overproduced in ischemic tissue to generate ATP during O2 deficit. Overproduction typically occurs during tissue hypoperfusion in hypovolemic, cardiac, or septic shock and is worsened by decreased lactate metabolism in the poorly perfused liver. It may also occur with primary hypoxia due to lung disease and with various hemoglobinopathies.
Type B lactic acidosis occurs in states of normal global tissue perfusion (and hence ATP production) and is less ominous. Lactate production may be increased from local relative hypoxia as with vigorous muscle use (eg, exertion, seizures, hypothermic shivering) and with cancer and ingestion of certain drugs or toxins. Drugs include the nucleoside reverse transcriptase inhibitors and the biguanidesphenformin and, less so, metformin ; although phenformin has been removed from the market in most of the world, it is still available from China (including as a component of some Chinese proprietary medicines). Metabolism may be decreased due to hepatic insufficiency or thiamin deficiency.
d-Lactic acidosis is an unusual form of lactic acidosis in which d-lactic acid, the product of bacterial carbohydrate metabolism in the colon of patients with jejunoileal bypass or intestinal resection, is systemically absorbed. It persists in circulation because human lactate dehydrogenase can metabolize only l-lactate.
Findings in and treatment of types A and B lactic acidosis are as for other metabolic acidoses. In d-lactic acidosis, the anion gap is lower than expected for the decrease in HCO3, and there may be a urinary osmolar gap (difference between calculated and measured urine osmolarity). Treatment is IV fluids, restriction of carbohydrates, and sometimes antibiotics (eg, metronidazole).

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Causes and symptoms

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