This document summarizes a meeting presentation about total syntheses of the natural product FR182877. Key points include:
- FR182877 is a cytotoxic natural product isolated from bacteria in 1998. It poses synthetic challenges due to its large hexacyclic structure containing multiple stereocenters.
- Total syntheses of both enantiomers of FR182877 have been achieved by the Sorensen and Evans groups using Diels-Alder cascades.
- The presentation discusses proposed biogenetic pathways, retrosynthetic analyses, key transformations such as Suzuki couplings and macrocyclization reactions, and studies of the stereoselectivity of the Diels-Alder cascade central to the
Jonathan R. Scheerer presented on the total synthesis of the alkaloid gephyrotoxin. Gephyrotoxin was first isolated from poison dart frogs and is a potent muscarinic antagonist. Several research groups, including Kishi and Overman, have achieved the total synthesis of both the natural and unnatural enantiomers of gephyrotoxin using retrosynthetic analyses involving aza-Cope rearrangements, Eschenmoser contractions, and stereoselective reductions. The seminar focused on the key steps that these groups used to construct the tricyclic core and install the functionalized enyne portion of the gephyrotoxin molecule.
The document summarizes research on gibberellins, a class of plant hormones. It outlines the presentation topics, which include the history and discovery of gibberellins, their biosynthesis, the structure and reactivity of gibberellic acid, conversions between gibberellins, and approaches to total and partial synthesis. It then provides highlights on the history of gibberellin research from the initial discovery of the "bakanae" disease in rice to the isolation and structural elucidation of gibberellic acid. Biosynthesis occurs in three stages, and the structures and rearrangements of gibberellic acid under basic and acidic conditions are shown. Methods for oxidizing different carbons on the gibberellin
1) Camptothecin is a natural alkaloid isolated from the Chinese camptotheca tree that was found to inhibit the enzyme topoisomerase I.
2) Monroe Wall and Mansukh Wani at Research Triangle Institute discovered and developed camptothecin and its analogs as promising anticancer agents in the 1960s-1980s.
3) Since then, over 100 derivatives have been synthesized using modern organic chemistry techniques like Diels-Alder reactions, radical annulations, and asymmetric syntheses.
4) Two FDA-approved camptothecin analogs, irinotecan and topotecan, are now important cancer drugs, with worldwide sales of $800
Slide Presentation from a Doctoral Virtual Open House presented on June 30, 2024 by staff and faculty of Capitol Technology University
Covers degrees offered, program details, tuition, financial aid and the application process.
Understanding and Interpreting Teachers’ TPACK for Teaching Multimodalities i...Neny Isharyanti
Presented as a plenary session in iTELL 2024 in Salatiga on 4 July 2024.
The plenary focuses on understanding and intepreting relevant TPACK competence for teachers to be adept in teaching multimodality in the digital age. It juxtaposes the results of research on multimodality with its contextual implementation in the teaching of English subject in the Indonesian Emancipated Curriculum.
Join educators from the US and worldwide at this year’s conference, themed “Strategies for Proficiency & Acquisition,” to learn from top experts in world language teaching.
How to Store Data on the Odoo 17 WebsiteCeline George
Here we are going to discuss how to store data in Odoo 17 Website.
It includes defining a model with few fields in it. Add demo data into the model using data directory. Also using a controller, pass the values into the template while rendering it and display the values in the website.
How to Add Colour Kanban Records in Odoo 17 NotebookCeline George
In Odoo 17, you can enhance the visual appearance of your Kanban view by adding color-coded records using the Notebook feature. This allows you to categorize and distinguish between different types of records based on specific criteria. By adding colors, you can quickly identify and prioritize tasks or items, improving organization and efficiency within your workflow.
(T.L.E.) Agriculture: Essentials of GardeningMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏.𝟎)-𝐅𝐢𝐧𝐚𝐥𝐬
Lesson Outcome:
-Students will understand the basics of gardening, including the importance of soil, water, and sunlight for plant growth. They will learn to identify and use essential gardening tools, plant seeds, and seedlings properly, and manage common garden pests using eco-friendly methods.
Views in Odoo - Advanced Views - Pivot View in Odoo 17Celine George
In Odoo, the pivot view is a graphical representation of data that allows users to analyze and summarize large datasets quickly. It's a powerful tool for generating insights from your business data.
The pivot view in Odoo is a valuable tool for analyzing and summarizing large datasets, helping you gain insights into your business operations.
Front Desk Management in the Odoo 17 ERPCeline George
Front desk officers are responsible for taking care of guests and customers. Their work mainly involves interacting with customers and business partners, either in person or through phone calls.
Credit limit improvement system in odoo 17Celine George
In Odoo 17, confirmed and uninvoiced sales orders are now factored into a partner's total receivables. As a result, the credit limit warning system now considers this updated calculation, leading to more accurate and effective credit management.
Principles of Roods Approach!!!!!!!.pptxibtesaam huma
Principles of Rood’s Approach
Treatment technique used in physiotherapy for neurological patients which aids them to recover and improve quality of life
Facilitatory techniques
Inhibitory techniques
