dactinomycin (Q186127)

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chemical compound

Cosmegen
ActD
Actinomycin D
2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-I)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Actinomycin iv
Meractinomycin
Actinomycin C1
GNF-Pf-1977
GNF-Pf-2290
Dactinomycin
Dactinomicina
Dactinomycine
Dactinomycinum

Language	Label	Description	Also known as
English	dactinomycin	chemical compound	Cosmegen ActD Actinomycin D 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-I)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide Actinomycin iv Meractinomycin Actinomycin C1 GNF-Pf-1977 GNF-Pf-2290 Dactinomycin Dactinomicina Dactinomycine Dactinomycinum

Statements

type of chemical entity

0 references

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heterocyclic compound

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RJURFGZVJUQBHK-HUZQGMAJSA-N

1 reference

based on heuristic

inferred from SMILES

response to actinomycin D

subject has role

1 reference

Gene Ontology release 2019-11-16

cellular response to actinomycin D

subject has role

1 reference

Gene Ontology release 2019-11-16

1 reference

language of work or name

Dactinomycin (English)

publication date

17 November 2015

chemical structure

Actinomycin D.svg
921 × 521; 133 KB

1 reference

imported from Wikimedia project

German Wikipedia

Actinomycin D.png
1,128 × 840; 27 KB

0 references

1,254.628 dalton

1 reference

language of work or name

DACTINOMYCIN (English)

17 November 2016

stereoisomer of

2-amino-4,6-dimethyl-3-oxo-N1,N9-bis[(3R,6S,7S,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

1 reference

based on heuristic

inferred from InChI

chemical formula

C₆₂H₈₆N₁₂O₁₆

1 reference

language of work or name

DACTINOMYCIN (English)

17 November 2016

canonical SMILES

CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

1 reference

language of work or name

DACTINOMYCIN (English)

17 November 2016

isomeric SMILES

C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C

1 reference

language of work or name

DACTINOMYCIN (English)

17 November 2016

active ingredient in

1 reference

14 February 2018

2 references

Crystal Structures of Actinomycin D and Actinomycin Z3

Antibacterial and Cytotoxic Actinomycins Y6-Y9 and Zp from Streptomyces sp. Strain Gö-GS12.

Streptomyces fradiae

1 reference

Structures of five components of the actinomycin Z complex from Streptomyces fradiae, two of which contain 4-chlorothreonine

Streptomyces antibioticus

2 references

Nematicidal potential of Streptomyces antibioticus strain M7 against Meloidogyne incognita

Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.

Streptomyces anulatus

2 references

Occurrence and biosynthesis of C-demethylactinomycins in actinomycin-producing Streptomyces chrysomallus and Streptomyces parvulus

Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.

Streptomyces heliomycini

1 reference

Identification, Bioactivity, and Productivity of Actinomycins from the Marine-Derived Streptomyces heliomycini

Streptomyces lividans

1 reference

Engineered Strains for Optimal Identification and Expression of Cryptic Biosynthetic Gene Clusters

Streptomyces sindenensis

1 reference

Enhanced antibiotic production by Streptomyces sindenensis using artificial neural networks coupled with genetic algorithm and Nelder-Mead downhill simplex.

Streptomyces parvulus

3 references

Actinomycin-Producing Endophytic Streptomyces parvulus Associated with Root of Aloe vera and Optimization of Conditions for Antibiotic Production

Occurrence and biosynthesis of C-demethylactinomycins in actinomycin-producing Streptomyces chrysomallus and Streptomyces parvulus

Production of polypeptide antibiotic from Streptomyces parvulus and its antibacterial activity

Streptomyces chrysomallus

2 references

Occurrence and biosynthesis of C-demethylactinomycins in actinomycin-producing Streptomyces chrysomallus and Streptomyces parvulus

Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.

Streptomyces flavovirens

1 reference

Identification and characterization of Streptomyces flavogriseus NJ-4 as a novel producer of actinomycin D and holomycin

Streptomyces flavogriseus

1 reference

Identification and characterization of Streptomyces flavogriseus NJ-4 as a novel producer of actinomycin D and holomycin

Streptomyces costaricanus

1 reference

Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073.

medical condition treated

testicular cancer

1 reference

language of work or name

13 December 2016

1 reference

language of work or name

13 December 2016

1 reference

language of work or name

13 December 2016

1 reference

language of work or name

13 December 2016

familial retinoblastoma

1 reference

language of work or name

13 December 2016

1 reference

language of work or name

13 December 2016

Kaposi's sarcoma

1 reference

language of work or name

13 December 2016

choriocarcinoma

1 reference

language of work or name

13 December 2016

connective tissue benign neoplasm

1 reference

language of work or name

13 December 2016

rhabdomyosarcoma

1 reference

language of work or name

13 December 2016

gestational trophoblastic neoplasm

10 December 1964

Food and Drug Administration

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/1CC1JFE158

http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050682s029s030lbl.pdf

testicular germ cell tumor non-seminomatous

10 December 1964

Food and Drug Administration

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/1CC1JFE158

http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050682s029s030lbl.pdf

10 December 1964

Food and Drug Administration

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/1CC1JFE158

http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050682s029s030lbl.pdf

pregnancy category

Australian pregnancy category D

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category D

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category C

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Dactinomycin

14 November 2017

subject has role

protein synthesis inhibitor

2 references

5 March 2018

Medical Subject Headings

MeSH descriptor ID

15 March 2018

DNA polymerase inhibitors

2 references

5 March 2018

Medical Subject Headings

MeSH descriptor ID

15 March 2018

1 reference

Medical Subject Headings

MeSH descriptor ID

15 March 2018

antineoplastic antibiotics

1 reference

Medical Subject Headings

MeSH descriptor ID

15 March 2018

1 reference

California Proposition 65 list of chemicals

25 February 2020

https://oehha.ca.gov/chemicals/actinomycin-d

developmental toxicant

1 October 1992

1 reference

California Proposition 65 list of chemicals

19 February 2020

https://oehha.ca.gov/chemicals/actinomycin-d

essential medicine

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DACTINomycin

has characteristic

Tall Man lettering

Institute for Safe Medication Practices

1 reference

https://www.ismp.org/recommendations/tall-man-letters-list

2 September 2022

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Commons category

Dactinomycin

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Identifiers

InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1

1 reference

RJURFGZVJUQBHK-IIXSONLDSA-N

2 references

language of work or name

DACTINOMYCIN (English)

17 November 2016

ChEBI release 2020-09-01

CAS Registry Number

1 reference

Global Substance Registration System

language of work or name

dactinomycin (English)

17 November 2016

1 reference

language of work or name

Actinomycin D (English)

17 November 2016

2 references

language of work or name

DACTINOMYCIN (English)

17 November 2016

matched by identifier from

RJURFGZVJUQBHK-IIXSONLDSA-N

mapping relation type

2 references

language of work or name

DACTINOMYCIN (English)

17 November 2016

matched by identifier from

International Chemical Identifier

InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1

1 reference

language of work or name

DACTINOMYCIN (English)

17 November 2016

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

RJURFGZVJUQBHK-IIXSONLDSA-N

UniChem compound ID

1 reference

splash10-0a4i-0102410096-3179cf52b2ed0b4e6890

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splash10-03di-2920003011-39d05616f78ee0afd099

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splash10-001i-1910000000-b4397216681296bde353

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CAMEO Chemicals ID

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AU1575000

1 reference

imported from Wikimedia project

French Wikipedia

0 references

1 reference

Hazardous Substances Data Bank

publication date

28 October 2019

DACTINOMYCIN (English)

10 May 2021

DSSTox substance ID

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

matched by identifier from

RJURFGZVJUQBHK-IIXSONLDSA-N

DSSTOX compound identifier

0 references

0 references

0 references

0 references

1 reference

Global Substance Registration System

language of work or name

dactinomycin (English)

17 November 2016

ECHA Substance Infocard ID

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

Dactinomycin (English)

CAS no.: 50-76-0 (English)

1 reference

language of work or name

Dactinomycin (English)

publication date

17 November 2015

MeSH descriptor ID

subject named as

Dactinomycin

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MeSH concept ID

0 references

D03.633.300.200

0 references

D04.345.566.252

0 references

D12.644.641.252

0 references

1 reference

Global Substance Registration System

language of work or name

dactinomycin (English)

17 November 2016

1 reference

matched by identifier from

RJURFGZVJUQBHK-IIXSONLDSA-N

Human Metabolome Database ID

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

RJURFGZVJUQBHK-IIXSONLDSA-N

2 references

Global Substance Registration System

language of work or name

dactinomycin (English)

17 November 2016

matched by identifier from

RJURFGZVJUQBHK-IIXSONLDSA-N

Natural Product Atlas ID

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

RJURFGZVJUQBHK-IIXSONLDSA-N

MedlinePlus drug identifier

0 references

NIAID ChemDB ID

1 reference

imported from Wikimedia project

English Wikipedia

1 reference

Global Substance Registration System

language of work or name

dactinomycin (English)

17 November 2016

Probes And Drugs ID

0 references

1 reference

1 reference

language of work or name

actinomycin D (English)

4 October 2016

1 reference

California Proposition 65 list of chemicals

13 November 2019

https://oehha.ca.gov/chemicals/actinomycin-d

0 references

electronic Essential Medicines List medicine ID

1 reference

https://list.essentialmeds.org/medicines/83

eEML - Electronic Essential Medicines List (English)

23 October 2021

Encyclopædia Britannica Online ID

topic/actinomycin-D

subject named as

actinomycin D

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science/dactinomycin

subject named as

dactinomycin

0 references

0 references

JSTOR topic ID (archived)

0 references

Microsoft Academic ID

0 references

NCI Dictionary of Cancer Terms entry

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

Global Substance Registration System

language of work or name

dactinomycin (English)

17 November 2016

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

WikiProjectMed ID

0 references

WordNet 3.1 Synset ID

02680456-n

1 reference

Sitelinks

Wikipedia(26 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Dactinomycin

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