MYC proto-oncogene, bHLH transcription factor (Q420267)

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mammalian protein found in Homo sapiens
  • avian myelocytomatosis viral oncogene homolog
  • MYC
  • bHLHe39
  • transcription factor p64
  • myc-related translation/localization regulatory factor
  • v-myc myelocytomatosis viral oncogene homolog
  • v-myc avian myelocytomatosis viral oncogene homolog
  • proto-oncogene c-Myc
  • class E basic helix-loop-helix protein 39
  • myc proto-oncogene protein
edit
Language Label Description Also known as
English
MYC proto-oncogene, bHLH transcription factor
mammalian protein found in Homo sapiens
  • avian myelocytomatosis viral oncogene homolog
  • MYC
  • bHLHe39
  • transcription factor p64
  • myc-related translation/localization regulatory factor
  • v-myc myelocytomatosis viral oncogene homolog
  • v-myc avian myelocytomatosis viral oncogene homolog
  • proto-oncogene c-Myc
  • class E basic helix-loop-helix protein 39
  • myc proto-oncogene protein

Statements

molecular function
protein binding
determination method or standard
IPI
53 references
retrieved
1 January 2018
stated in
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Yaf2 inhibits Myc biological function
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Fbw7 and Usp28 regulate myc protein stability in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Noninvasive molecular imaging of c-Myc activation in living mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Proteomic profiling of Myc-associated proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Deterministic direct reprogramming of somatic cells to pluripotency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Sin3b interacts with Myc and decreases Myc levels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
NEMO stabilizes c‐Myc through direct interaction in the nucleus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
HPV-18 E7 conjugates to c-Myc and mediates its transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Targeting of Miz-1 is essential for Myc-mediated apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
CIP2A inhibits PP2A in human malignancies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
IκB kinases increase Myc protein stability and enhance progression of breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Epstein-Barr virus nuclear antigen 3C interacts with and enhances the stability of the c-Myc oncoprotein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Inhibition of c-Myc activity by ribosomal protein L11
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
retrieved
1 January 2018
stated in
Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
IEA
TAS
6 references
retrieved
1 January 2018
stated in
Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IEA
retrieved
1 January 2018
stated in
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
GOA
curator
UniProt
UniProt protein ID
P01106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IDA
retrieved
1 January 2018
stated in
Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IDA
retrieved
1 January 2018
stated in
Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106
determination method or standard
IDA
biological process

Identifiers

MeSH descriptor ID
C489427
subject named as
MYC protein, human
0 references
 
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