Indoleamine 2,3-dioxygenase 1 (Q908221)

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mammalian protein found in Homo sapiens

• indolamine 2,3 dioxygenase
• indoleamine 2,3-dioxygenase 1
• IDO1
• indoleamine-pyrrole 2,3-dioxygenase
• indole 2,3-dioxygenase
• IDO1 protein, human

edit

Language	Label	Description	Also known as
English	Indoleamine 2,3-dioxygenase 1	mammalian protein found in Homo sapiens	indolamine 2,3 dioxygenase indoleamine 2,3-dioxygenase 1 IDO1 indoleamine-pyrrole 2,3-dioxygenase indole 2,3-dioxygenase IDO1 protein, human

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14902

part of

Tryptophan/Indoleamine 2,3-dioxygenase-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14902

Indoleamine 2,3-dioxygenase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14902

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14902

encoded by

IDO1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14902

molecular function

dioxygenase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

metal ion binding

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

heme binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

electron transfer activity

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

TAS

oxidoreductase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

indoleamine 2,3-dioxygenase activity

determination method or standard

IEA

IMP

2 references

retrieved

5 June 2018

stated in

Human renal tubular epithelial cells suppress alloreactive T cell proliferation

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IMP

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

tryptophan 2,3-dioxygenase activity

determination method or standard

EXP

IEA

2 references

retrieved

5 June 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

5 June 2018

stated in

Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

EXP

tryptophan 2,3-dioxygenase activity

determination method or standard

EXP

IBA

IEA

3 references

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IBA

retrieved

1 January 2018

stated in

Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

EXP

indoleamine 2,3-dioxygenase activity

determination method or standard

IBA

IEA

IMP

3 references

retrieved

8 April 2019

stated in

Human renal tubular epithelial cells suppress alloreactive T cell proliferation

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IBA

tryptophan 2,3-dioxygenase activity

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IBA

cell component

cytoplasm

determination method or standard

IEA

2 references

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

5 June 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

stereocilium bundle

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

cytosol

determination method or standard

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

smooth muscle contractile fiber

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

cytoplasm

determination method or standard

IBA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IBA

biological process

negative regulation of interleukin-10 production

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

multicellular organismal response to stress

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

positive regulation of interleukin-12 production

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

immune system process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

female pregnancy

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Prevention of allogeneic fetal rejection by tryptophan catabolism

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

TAS

positive regulation of T cell tolerance induction

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

cytokine production involved in inflammatory response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

positive regulation of chronic inflammatory response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

negative regulation of T cell apoptotic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

regulation of activated T cell proliferation

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Human renal tubular epithelial cells suppress alloreactive T cell proliferation

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IMP

response to lipopolysaccharide

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

negative regulation of T cell proliferation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

positive regulation of apoptotic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

tryptophan catabolic process

determination method or standard

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

TAS

retrieved

8 April 2019

stated in

Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

positive regulation of type 2 immune response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

inflammatory response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

kynurenic acid biosynthetic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

positive regulation of T cell apoptotic process

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Human renal tubular epithelial cells suppress alloreactive T cell proliferation

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IMP

swimming behavior

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

tryptophan catabolic process to kynurenine

determination method or standard

IEA

3 references

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

5 June 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

5 June 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14902&geneProductId=UniProtKB:P14902

determination method or standard

IEA

electron transport chain

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

tryptophan catabolic process to kynurenine

determination method or standard

IBA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14902

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IBA

'de novo' NAD biosynthetic process from tryptophan

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14902

determination method or standard

IBA

physically interacts with

norharman

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8222

language of work or name

English

retrieved

17 August 2016

epacadostat

object of statement has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL3545369

product, material, or service produced or provided

N-formylkynurenine

0 references

Gene Atlas image

PBB GE INDO 210029 at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

C576710

subject named as

IDO1 protein, human

0 references

RefSeq protein ID

NP_002155

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3620

UniProt protein ID

P14902

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14902

Ensembl protein ID

ENSP00000430505

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000430505

ENSP00000430950

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000430950

ENSP00000253513

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000253513

ENSP00000428716

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000428716

ENSP00000429297

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000429297

ENSP00000429933

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000429933

Freebase ID

/m/026t44t

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

83478079

0 references

OpenAlex ID

C83478079

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

2D0T

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

2D0U

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

4PK5

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

4PK6

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

4U72

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

4U74

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

5EK2

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

5EK3

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

5EK4

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

5ETW

1 reference

stated in

UniProt

UniProt protein ID

P14902

retrieved

9 August 2016

language of work or name

English

UMLS CUI

C3529891

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(13 entries)

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• cswiki Indolamin 2,3-dioxygenáza
• dewiki Indolamin-2,3-Dioxygenase
• enwiki Indoleamine 2,3-dioxygenase
• frwiki Indoleamine 2,3-dioxygénase
• jawiki インドールアミン-2,3-ジオキシゲナーゼ
• kowiki 인돌아민 2,3-이산소화효소
• plwiki 2,3-dioksygenaza indolaminy
• ptwiki Indoleamina 2,3-dioxigenase
• shwiki Indolamin 2,3-dioksigenaza
• srwiki Indolamin 2,3-dioksigenaza
• ttwiki IDO1
• ukwiki IDO1
• viwiki Indoleamine 2,3-dioxygenase

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q908221&oldid=2022902974"