Papers by Ayman Al-Labban
International Journal of Pharmacy and Pharmaceutical Sciences
A new rapid, simple, sensitive, and accurate spectrophotometric method have been developed, to de... more A new rapid, simple, sensitive, and accurate spectrophotometric method have been developed, to determine of esomeprazole (EMZ) in its dosage forms. The method was based on the formation of a charge-transfer complexe between chloranilic acid (CAA) as a π-acceptor and EMZ as an n-donor in methanol-acetonitril medium. The maximum absorbance of the coloured complex occurred at 521-525 nm and the molar absorptivity 4.932x103 L.mol-1.cm-1 . The molar combining ratio and the optimum assay conditions were studied. Under optimum conditions, the stoichiometry of the reactions between EMZ and the CAA was found to be 1:2 and 1:4. The linear ranges for the proposed method were 1.250–150.00 μgmL−1 .The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.156μg.mL-1 and 0.473 μg.mL-1 respectively, with RSD was 4.6% . The proposed method was successfully applied to the analysis of esomeprazole magnesium in pure and pharmaceutical dosage forms with average recovery of 98.26–1...
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Papers by Ayman Al-Labban