Sana Jamshaid is a dynamic and innovative researcher, educator, and social activist known for her profound contributions to the field of chemistry and her dedication to empowering women in STEM (Science, Technology, Engineering, and Mathematics) fields. Her journey is marked by academic excellence, groundbreaking research, and a commitment to making a positive impact on society. Supervisors: Yong Rok Lee
A facile and efficient In(OTf)3- and BF3·OEt2-catalyzed direct transformation of 3-formylindoles ... more A facile and efficient In(OTf)3- and BF3·OEt2-catalyzed direct transformation of 3-formylindoles with diazo esters has been developed for synthesizing diverse and functionalized indolyl acrylates. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates, and (Z)-3-hydroxy-2-indolyl acrylates by a catalyst- and substituent-controlled, regio- and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds can be further converted into diversely functionalized materials.
Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure ... more Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure of flu. Because normal nose breathing help us to use nitric oxide generated in our sinuses. And research told us that nitric oxide has confirmed function of destruction of viruses, parasitic organisms, and malignant cells in the airways and lungs by inactivating their respiratory chain enzymes. NO inhibits the replication of influenza viruses, probably during the early steps of the viruses' replication cycle, involving the synthesis of vRNA and mRNA encoding viral proteins. Thus NO is responsible for the cure of flu by killing influenza virus.
Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure ... more Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure of flu. Because normal nose breathing help us to use nitric oxide generated in our sinuses. And research told us that nitric oxide has confirmed function of destruction of viruses, parasitic organisms, and malignant cells in the airways and lungs by inactivating their respiratory chain enzymes. NO inhibits the replication of influenza viruses, probably during the early steps of the viruses’ replication cycle, involving the synthesis of vRNA and mRNA encoding viral proteins. Thus NO is responsible for the cure of flu by killing influenza virus.
An In(iii)-catalyzed and solvent-free multicomponent one-pot N-annulation for the construction of... more An In(iii)-catalyzed and solvent-free multicomponent one-pot N-annulation for the construction of highly fused pyridines as novel fluorophores is developed.
In the original publication, one of the co-authors name Sana Jamshaid was missed out. The correct... more In the original publication, one of the co-authors name Sana Jamshaid was missed out. The correct authors' group is updated in this correction.
A facile and efficient In(OTf) 3-and BF 3 ·OEt 2-catalyzed direct transformation of 3-formylindol... more A facile and efficient In(OTf) 3-and BF 3 ·OEt 2-catalyzed direct transformation of 3-formylindoles with diazo esters has been developed for synthesizing diverse and functionalized indolyl acrylates. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indol-yl acrylates, and (Z)-3-hydroxy-2-indolyl acrylates by a catalyst-and substituent-controlled, regio-and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds can be further converted into diversely functionalized materials. D iazo compounds are one of the most valuable starting materials and versatile intermediates in organic synthesis. 1,2 They have been extensively used to synthesize bioactive natural products, 3 pharmaceuticals, 4 and many heterocycles. 5 The transition-metal-catalyzed, thermal, and photoreactions of diazo compounds have been well explored for the synthesis of diverse molecules. 6 In this regard, several synthetic methodologies based on the use of arylaldehydes and diazo acetates have been reported, including transition-metal-catalyzed olefination, 7 racemic or asymmetric aldol-type addition for β-hydroxy-α-ketoesters, 8,9 Lewis-acid-and metal-catalyzed formation of β-ketoesters, 10 and transition-metal-catalyzed epoxidation. 11 Although the capabilities of diazo compounds for olefination, β-hydroxy-α-ketoester formation, and β-ketoester epoxidation are well established, their ability to afford unsaturated α-hydroxy esters has not yet been elucidated. Indoles are the principal scaffolds in several bioactive natural and synthetic products and are also present in many pharmaceuticals. 12 The indole moiety of indolic compounds is currently present in 24 commercialized pharmaceuticals. 13 In particular, the formyl group of indoles is an important synthetic building block in organic synthesis as well in the chemical industry. 14 Among them, 3-formylindoles and their derivatives are key starting materials and intermediates in the preparation of biologically active molecules through organic reaction transformation. 15 A few methods using diazo esters have been reported for the transformation of 3-formylindoles. For example, the Lebel group has demonstrated the copper-catalyzed olefination of 3-formylindole with diazo acetate for the preparation of conjugated esters (Scheme 1A). 16 The TrBF 4-catalyzed reaction of 3-formylcarbonyl with α-diazo acetates to yield the corresponding β-keto esters was also reported by the Lv group (Scheme 1B). 17 However, the Lewis-acid-catalyzed reaction of 3-formylindoles with diazo acetates to afford conjugated esters bearing α-hydroxy or β-alkoxyester groups is yet to be studied. Thus we envisioned the development of a novel protocol for introducing new moieties at the three-position on the indole nuclei, starting from 3-formyl indoles and diazo esters. We have previously developed new methodologies to synthesize biologically interesting heterocycles 18 and diverse organic molecules starting from diazo compounds. 19 Extending the study of diazo-compound-based synthetic new protocols, herein we report a novel and efficient strategy to synthesize biologically important (Z)-α-hydroxy-β-indolyl acrylates via oxygen atom transfer (Scheme 1C), (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates via indolyl migration (Scheme 1D), and (Z)-3-hydroxy-2-indolyl acrylates via indolyl migration (Scheme 1E) by In(OTf) 3-and BF 3 ·OEt 2-catalyzed reactions of 3-formylindoles and diazo esters. The reaction of 1-methylindole-3-carboxaldehyde (1a) with ethyl diazoacetate (2a) was investigated using different solvents and catalysts (Table 1). In initial attempts with
A B S T R A C T Future energy security and environmental issues are major driving forces for incr... more A B S T R A C T Future energy security and environmental issues are major driving forces for increased biomass utilization globally and especially in developing countries like Pakistan. For efficient utilization of indigenous biomass resources in the future energy mix, it is important to gain knowledge of current energy system in various sectors. Some of the technologies and initiatives are under development to achieve transition from non-renewable resources to renewable resources, and reducing fossil fuel dependency and greenhouse gas emissions. Recently, number of proposals has been presented for the development of sustainable biofuels production methods for promise for accelerating a shift away from an unsustainable approach to possible sustainable production practices or a sustainable social, economic and environment. This article presents an extensive literature review of the biomass-based renewable energy potential in Pakistan based on current energy scenario and future perspectives. It also highlights the availability of the indigenous and local biomass resources and potential biomass conversion technologies to convert such resources to bioenergy. The drivers for utilization of indigenous biomass resources in future energy mix and challenges regarding awareness among stakeholders and R & D to fill knowledge gaps are economically restraints. The article concludes with suggestions on future directions and policies for effective implementation of biomass based renewable energy production.
A facile and efficient In(OTf)3- and BF3·OEt2-catalyzed direct transformation of 3-formylindoles ... more A facile and efficient In(OTf)3- and BF3·OEt2-catalyzed direct transformation of 3-formylindoles with diazo esters has been developed for synthesizing diverse and functionalized indolyl acrylates. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates, and (Z)-3-hydroxy-2-indolyl acrylates by a catalyst- and substituent-controlled, regio- and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds can be further converted into diversely functionalized materials.
Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure ... more Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure of flu. Because normal nose breathing help us to use nitric oxide generated in our sinuses. And research told us that nitric oxide has confirmed function of destruction of viruses, parasitic organisms, and malignant cells in the airways and lungs by inactivating their respiratory chain enzymes. NO inhibits the replication of influenza viruses, probably during the early steps of the viruses' replication cycle, involving the synthesis of vRNA and mRNA encoding viral proteins. Thus NO is responsible for the cure of flu by killing influenza virus.
Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure ... more Breathing through nose is a healthy habit approved by researchers and it is also helpful in cure of flu. Because normal nose breathing help us to use nitric oxide generated in our sinuses. And research told us that nitric oxide has confirmed function of destruction of viruses, parasitic organisms, and malignant cells in the airways and lungs by inactivating their respiratory chain enzymes. NO inhibits the replication of influenza viruses, probably during the early steps of the viruses’ replication cycle, involving the synthesis of vRNA and mRNA encoding viral proteins. Thus NO is responsible for the cure of flu by killing influenza virus.
An In(iii)-catalyzed and solvent-free multicomponent one-pot N-annulation for the construction of... more An In(iii)-catalyzed and solvent-free multicomponent one-pot N-annulation for the construction of highly fused pyridines as novel fluorophores is developed.
In the original publication, one of the co-authors name Sana Jamshaid was missed out. The correct... more In the original publication, one of the co-authors name Sana Jamshaid was missed out. The correct authors' group is updated in this correction.
A facile and efficient In(OTf) 3-and BF 3 ·OEt 2-catalyzed direct transformation of 3-formylindol... more A facile and efficient In(OTf) 3-and BF 3 ·OEt 2-catalyzed direct transformation of 3-formylindoles with diazo esters has been developed for synthesizing diverse and functionalized indolyl acrylates. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indol-yl acrylates, and (Z)-3-hydroxy-2-indolyl acrylates by a catalyst-and substituent-controlled, regio-and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds can be further converted into diversely functionalized materials. D iazo compounds are one of the most valuable starting materials and versatile intermediates in organic synthesis. 1,2 They have been extensively used to synthesize bioactive natural products, 3 pharmaceuticals, 4 and many heterocycles. 5 The transition-metal-catalyzed, thermal, and photoreactions of diazo compounds have been well explored for the synthesis of diverse molecules. 6 In this regard, several synthetic methodologies based on the use of arylaldehydes and diazo acetates have been reported, including transition-metal-catalyzed olefination, 7 racemic or asymmetric aldol-type addition for β-hydroxy-α-ketoesters, 8,9 Lewis-acid-and metal-catalyzed formation of β-ketoesters, 10 and transition-metal-catalyzed epoxidation. 11 Although the capabilities of diazo compounds for olefination, β-hydroxy-α-ketoester formation, and β-ketoester epoxidation are well established, their ability to afford unsaturated α-hydroxy esters has not yet been elucidated. Indoles are the principal scaffolds in several bioactive natural and synthetic products and are also present in many pharmaceuticals. 12 The indole moiety of indolic compounds is currently present in 24 commercialized pharmaceuticals. 13 In particular, the formyl group of indoles is an important synthetic building block in organic synthesis as well in the chemical industry. 14 Among them, 3-formylindoles and their derivatives are key starting materials and intermediates in the preparation of biologically active molecules through organic reaction transformation. 15 A few methods using diazo esters have been reported for the transformation of 3-formylindoles. For example, the Lebel group has demonstrated the copper-catalyzed olefination of 3-formylindole with diazo acetate for the preparation of conjugated esters (Scheme 1A). 16 The TrBF 4-catalyzed reaction of 3-formylcarbonyl with α-diazo acetates to yield the corresponding β-keto esters was also reported by the Lv group (Scheme 1B). 17 However, the Lewis-acid-catalyzed reaction of 3-formylindoles with diazo acetates to afford conjugated esters bearing α-hydroxy or β-alkoxyester groups is yet to be studied. Thus we envisioned the development of a novel protocol for introducing new moieties at the three-position on the indole nuclei, starting from 3-formyl indoles and diazo esters. We have previously developed new methodologies to synthesize biologically interesting heterocycles 18 and diverse organic molecules starting from diazo compounds. 19 Extending the study of diazo-compound-based synthetic new protocols, herein we report a novel and efficient strategy to synthesize biologically important (Z)-α-hydroxy-β-indolyl acrylates via oxygen atom transfer (Scheme 1C), (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates via indolyl migration (Scheme 1D), and (Z)-3-hydroxy-2-indolyl acrylates via indolyl migration (Scheme 1E) by In(OTf) 3-and BF 3 ·OEt 2-catalyzed reactions of 3-formylindoles and diazo esters. The reaction of 1-methylindole-3-carboxaldehyde (1a) with ethyl diazoacetate (2a) was investigated using different solvents and catalysts (Table 1). In initial attempts with
A B S T R A C T Future energy security and environmental issues are major driving forces for incr... more A B S T R A C T Future energy security and environmental issues are major driving forces for increased biomass utilization globally and especially in developing countries like Pakistan. For efficient utilization of indigenous biomass resources in the future energy mix, it is important to gain knowledge of current energy system in various sectors. Some of the technologies and initiatives are under development to achieve transition from non-renewable resources to renewable resources, and reducing fossil fuel dependency and greenhouse gas emissions. Recently, number of proposals has been presented for the development of sustainable biofuels production methods for promise for accelerating a shift away from an unsustainable approach to possible sustainable production practices or a sustainable social, economic and environment. This article presents an extensive literature review of the biomass-based renewable energy potential in Pakistan based on current energy scenario and future perspectives. It also highlights the availability of the indigenous and local biomass resources and potential biomass conversion technologies to convert such resources to bioenergy. The drivers for utilization of indigenous biomass resources in future energy mix and challenges regarding awareness among stakeholders and R & D to fill knowledge gaps are economically restraints. The article concludes with suggestions on future directions and policies for effective implementation of biomass based renewable energy production.
Schiff bases are an important class of organic compounds. The common structural feature of these ... more Schiff bases are an important class of organic compounds. The common structural feature of these compounds have the azomethine group with the general formula RHC = N-R1, where R and R1 are alkyl, aryl, cycloalkyl, or heterocyclic groups. Schiff bases have also been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, antipyretic properties and also have some industrial applications. The imine group present in such compounds has been shown to be critical to their biological activities
Schiff bases are synthesized by Sterker reaction in which condensation of primary aromatic amines with aryl aldehydes is found to be catalyzed by using mild catalysts in presence of organic solvent.
Owing to vast applications of Schiff bases in field of medicine, agriculture and industry; the work presented here was carried out to synthesize indole based Schiff bases. Different substituted anilines and novel-indolic aldehyde are used to synthesize various kinds of imines using green procedure that doesn’t require excess of organic solvents. This eco-friendly reaction has many advantages like economical, medicinal, environmental and with mild reaction conditions, simple work-up yield high products.
Chemistry is not limited to beakers and laboratories. It is all around us, and the better we know... more Chemistry is not limited to beakers and laboratories. It is all around us, and the better we know chemistry, the better we know our world.
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Schiff bases are synthesized by Sterker reaction in which condensation of primary aromatic amines with aryl aldehydes is found to be catalyzed by using mild catalysts in presence of organic solvent.
Owing to vast applications of Schiff bases in field of medicine, agriculture and industry; the work presented here was carried out to synthesize indole based Schiff bases. Different substituted anilines and novel-indolic aldehyde are used to synthesize various kinds of imines using green procedure that doesn’t require excess of organic solvents. This eco-friendly reaction has many advantages like economical, medicinal, environmental and with mild reaction conditions, simple work-up yield high products.