The 2021 Sioux Chief PowerPEX 200 presented by Scott County Tourism was the 19th stock car race of the 2021 ARCA Menards Series, the tenth and final race of the , and the 25th iteration of the event. The race was held on Saturday, October 2, 2021 in Salem, Indiana at Salem Speedway, a 0.555 miles (0.893 km) permanent paved oval-shaped racetrack. The race took the scheduled 200 laps to complete. On the final restart on lap 156, Jesse Love of Venturini Motorsports would take the lead and lead every lap afterwards to win his first career ARCA Menards Series win and his only win of the season. Meanwhile, Ty Gibbs of Joe Gibbs Racing, who would finish second, would win the championship, winning the championship by 22 points. To fill out the podium, Rajah Caruth of Rev Racing would finish third
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