About: Acylfulvene

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom (Omphalotus olearius). One important acylfulvene, 6-hydroxymethylacylfulvene (irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors. It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation).

Property	Value
dbo:abstract	Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom (Omphalotus olearius). One important acylfulvene, 6-hydroxymethylacylfulvene (irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors. It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation). (en)
dbo:iupacName	(6′R)-6′-Hydroxy-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-inden]-7′(6′H)-one (en)
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dbp:imagefile	acylfulvene.png (en)
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gold:hypernym	dbr:Derivatives
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rdfs:comment	Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom (Omphalotus olearius). One important acylfulvene, 6-hydroxymethylacylfulvene (irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors. It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation). (en)
rdfs:label	Acylfulvene (en)
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