About: Aloxistatin

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Aloxistatin (loxistatin, E-64d, EST) is a drug which acts as a cysteine protease inhibitor and has anticoagulant effects. It is a synthetic analogue of E-64, a natural product derived from fungi. It was researched for the treatment of muscular dystrophy but was not successful in human clinical trials, though it has continued to be investigated for treatment of spinal cord injury, stroke and Alzheimer's disease. It also shows antiviral effects.

Property	Value
dbo:abstract	Aloxistatin (loxistatin, E-64d, EST) is a drug which acts as a cysteine protease inhibitor and has anticoagulant effects. It is a synthetic analogue of E-64, a natural product derived from fungi. It was researched for the treatment of muscular dystrophy but was not successful in human clinical trials, though it has continued to be investigated for treatment of spinal cord injury, stroke and Alzheimer's disease. It also shows antiviral effects. (en)
dbo:casNumber	88321-09-9
dbo:chEBI	101381
dbo:chEMBL	63440
dbo:fdaUniiCode	L5W337AOUR
dbo:pubchem	65663
dbo:thumbnail	wiki-commons:Special:FilePath/Aloxistatin_structure.png?width=300
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dbo:wikiPageLength	6112 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1123279806 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Anticoagulant dbc:Antiviral_drugs dbc:Epoxides dbc:Anticoagulants dbr:Stroke dbr:Clinical_trial dbc:Carboxamides dbr:Cysteine_protease dbr:E-64 dbr:Alzheimer's_disease dbc:Ethyl_esters dbc:Dipeptides dbr:Spinal_cord_injury dbr:Antiviral dbr:Muscular_dystrophy dbr:(2S)-4-methyl-1-(3-methylbutylamino)-1...bamoyl]oxirane-2-carboxylate</nowiki>
dbp:atcPrefix	none (en)
dbp:c	17 (xsd:integer)
dbp:casNumber	88321 (xsd:integer)
dbp:chebi	101381 (xsd:integer)
dbp:chembl	63440 (xsd:integer)
dbp:chemspiderid	59098 (xsd:integer)
dbp:h	30 (xsd:integer)
dbp:iupacName	ethyl -3-(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate (en)
dbp:legalUs	Investigational drug (en)
dbp:n	2 (xsd:integer)
dbp:o	5 (xsd:integer)
dbp:pubchem	65663 (xsd:integer)
dbp:smiles	CCOC[C@@H]1[C@H]CN[C@@H]CNCCCC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	SRVFFFJZQVENJC-IHRRRGAJSA-N (en)
dbp:unii	L5W337AOUR (en)
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dcterms:subject	dbc:Antiviral_drugs dbc:Epoxides dbc:Anticoagulants dbc:Carboxamides dbc:Ethyl_esters dbc:Dipeptides
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	Aloxistatin (loxistatin, E-64d, EST) is a drug which acts as a cysteine protease inhibitor and has anticoagulant effects. It is a synthetic analogue of E-64, a natural product derived from fungi. It was researched for the treatment of muscular dystrophy but was not successful in human clinical trials, though it has continued to be investigated for treatment of spinal cord injury, stroke and Alzheimer's disease. It also shows antiviral effects. (en)
rdfs:label	Aloxistatin (en)
owl:sameAs	wikidata:Aloxistatin dbpedia-fa:Aloxistatin https://global.dbpedia.org/id/2YXGk
prov:wasDerivedFrom	wikipedia-en:Aloxistatin?oldid=1123279806&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Aloxistatin_structure.png
foaf:isPrimaryTopicOf	wikipedia-en:Aloxistatin
is dbo:wikiPageRedirects of	dbr:C17H30N2O5 dbr:Loxistatin dbr:E64D
is dbo:wikiPageWikiLink of	dbr:Endopeptidase_inhibitor dbr:C17H30N2O5 dbr:E-64 dbr:List_of_drugs:_Al dbr:Loxistatin dbr:E64D
is foaf:primaryTopic of	wikipedia-en:Aloxistatin

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