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- Apyrase (EC 3.6.1.5, ATP-diphosphatase, adenosine diphosphatase, ADPase, ATP diphosphohydrolase) is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yield AMP and inorganic phosphate. Two isoenzymes are found in commercial preparations from S. tuberosum. One with a higher ratio of substrate selectivity for ATP:ADP (approx 10) and another with no selectivity (ratio 1). It can also act on ADP and other nucleoside triphosphates and diphosphates with the general reaction being NTP -> NDP + Pi -> NMP + 2Pi. This is the same activity that has been employed in the degradation of unincorporated nucleosides during pyrosequencing. The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes that are implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate. (en)
- L'apyrase est une hydrolase qui catalyse les réactions : 1.
* nucléoside-5’-triphosphate + H2O nucléoside-5’-diphosphate + phosphate ; 2.
* nucléoside-5’-diphosphate + H2O nucléoside-5’-phosphate + phosphate. Cette enzyme est une protéine membranaire utilisant le cation de calcium Ca2+ comme cofacteur ; elle fonctionne également avec le cation de magnésium Mg2+. Elle a pour fonction d'hydrolyser essentiellement l'ATP et l'ADP du milieu extracellulaire, bien que toutes les apyrases ne soient pas des ectoenzymes et que certaines se trouvent à l'intérieur des cellules, comme c'est le cas de la protéine codée par le gène LALP1 chez l'homme et la souris. Les apyrases se distinguent des ATPases par le fait que ces dernières, qui sont également des protéines membranaires, n'hydrolysent que l'ATP, du côté intracellulaire, et dans le but d'assurer le transport actif d'espèces chimiques à travers la membrane. Les apyrases salivaires des arthropodes hématophages interviennent dans l'inhibition de l'agrégation des thrombocytes (plaquettes sanguines) en hydrolysant l'ADP extracellulaire, ce qui fait l'objet de recherches pharmaceutiques en vue d'applications comme anticoagulants. (fr)
- Apirase (também ADPase, adenosina difosfatase) é uma enzima anticoagulante. Encontra-se na glândula salivar presente nos insetos hematófagos e tem a função de impedir a agregação plaquetária e proporcionar vasodilatação na hora da picada. Desta forma, é obtida hemorragia local, proporcionando uma maior rapidez na sucção do sangue. (pt)
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- structure and protein design of human apyrase (en)
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- Apirase (também ADPase, adenosina difosfatase) é uma enzima anticoagulante. Encontra-se na glândula salivar presente nos insetos hematófagos e tem a função de impedir a agregação plaquetária e proporcionar vasodilatação na hora da picada. Desta forma, é obtida hemorragia local, proporcionando uma maior rapidez na sucção do sangue. (pt)
- Apyrase (EC 3.6.1.5, ATP-diphosphatase, adenosine diphosphatase, ADPase, ATP diphosphohydrolase) is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yield AMP and inorganic phosphate. Two isoenzymes are found in commercial preparations from S. tuberosum. One with a higher ratio of substrate selectivity for ATP:ADP (approx 10) and another with no selectivity (ratio 1). (en)
- L'apyrase est une hydrolase qui catalyse les réactions : 1.
* nucléoside-5’-triphosphate + H2O nucléoside-5’-diphosphate + phosphate ; 2.
* nucléoside-5’-diphosphate + H2O nucléoside-5’-phosphate + phosphate. (fr)
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- Apyrase (en)
- Apyrase (fr)
- Apirase (pt)
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