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- Cruzipain is a cysteine protease expressed by Trypanosoma cruzi. It is classified under EC 3.4.22.51. Cruzipain is expressed by all strains and developmental forms of Trypanosoma cruzi. It is secreted and can be found in the membrane of the parasite. The study of Trypanosoma cruzi virulence is difficult due to the complexity of the parasite’s biology. Trypanosoma cruzi has two different infective forms which are both biochemically and antigenically distinct. The two forms, MTs and blood trypomastigotes use distinct sets of surface molecules to interact with their respective hosts. Trypanosoma cruzi also uses unique processes for gene expression, such as RNA editing, trans-splicing, and constitutive polycistronic transcription of protein-coding genes. In the absence of mechanisms controlling initiation of transcription, extracellular signals will trigger subsets of Trypanosoma cruzi genes to be post-transcriptionally co-regulated. Cruzipain is part of clan CA, a group of papain-like protease enzymes. Clan CA is the most studied class of cysteine proteinases in parasitic protozoa. The localization of cruzipain within the cell differs based on which stage of the biological cycle the parasite is in. Cruzipain is involved in aiding the parasite in penetrating and evading the immune response of the host. The cysteine peptidases within parasitic protozoa are pivotal for several biological processes. Metamorphosis, immune evasion, and adaptation to certain hosts are some of the processes that cruzipain can exert influence over. Cruzipain is a sulfated glycoprotein which plays a role in the parasitic disease known as Chagas disease. It is found to aid the parasite in entering the host cell and in evading an immune response. Cruzipain can help parasites escape the response from the adaptive immune system by interfering with the functions of immunoglobulins from the immunoglobin G subclasses. These immunoglobulins are bound to receptors and cruzipain interacts with these immunoglobulins by cleaving their hinges. During smooth muscle cell invasion, cruzipain may mobilize vasoconstricting endothelin receptors, which may interfere with the vasoconstrictor's ability to cause the blood vessels to become narrower. Cruzipain aids in the process of breaking down host tissue and is prepared to signal the escape mechanism if it detects any response from the host's immune system. (en)
- クルジパイン（英: cruzipain、EC 3.4.22.51）は、クルーズトリパノソーマ（Trypanosoma cruzi）が産生するシステインプロテアーゼである。 クルジパインは硫酸化糖タンパク質であり、シャーガス病として知られる寄生虫疾患に関与している。クルジパインは、寄生虫の宿主細胞への進入と免疫応答の回避を補助することが判明している。 クルジパインはIgGクラスの免疫グロブリンの機能に干渉することで、獲得免疫系による応答の回避を助けている。クルジパインはIgGと相互作用し、ヒンジ領域を切断する。 平滑筋細胞への侵入時には、クルジパインは血管収縮作用を持つを切断し、血管収縮作用に干渉している可能性がある。 クルジパインは宿主組織を破壊する過程を補助し、宿主の免疫系の応答を検知した際の逃避機構へのシグナル伝達にも備えている。 (ja)
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- 9379 (xsd:nonNegativeInteger)
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- クルジパイン（英: cruzipain、EC 3.4.22.51）は、クルーズトリパノソーマ（Trypanosoma cruzi）が産生するシステインプロテアーゼである。 クルジパインは硫酸化糖タンパク質であり、シャーガス病として知られる寄生虫疾患に関与している。クルジパインは、寄生虫の宿主細胞への進入と免疫応答の回避を補助することが判明している。 クルジパインはIgGクラスの免疫グロブリンの機能に干渉することで、獲得免疫系による応答の回避を助けている。クルジパインはIgGと相互作用し、ヒンジ領域を切断する。 平滑筋細胞への侵入時には、クルジパインは血管収縮作用を持つを切断し、血管収縮作用に干渉している可能性がある。 クルジパインは宿主組織を破壊する過程を補助し、宿主の免疫系の応答を検知した際の逃避機構へのシグナル伝達にも備えている。 (ja)
- Cruzipain is a cysteine protease expressed by Trypanosoma cruzi. It is classified under EC 3.4.22.51. Cruzipain is expressed by all strains and developmental forms of Trypanosoma cruzi. It is secreted and can be found in the membrane of the parasite. Cruzipain is a sulfated glycoprotein which plays a role in the parasitic disease known as Chagas disease. It is found to aid the parasite in entering the host cell and in evading an immune response. (en)
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- Cruzipain (en)
- クルジパイン (ja)
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