About: Cyclorphan

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Cyclorphan is an opioid analgesic of the morphinan family that was never marketed. It acts as a μ-opioid receptor (MOR) weak partial agonist or antagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR). The drug was first synthesized in 1964 by scientists at Research Corporation. In clinical trials, it had relatively long duration, good absorption, and provided strong pain relief but produced psychotomimetic effects via KOR activation, so its development was not continued.

Property	Value
dbo:abstract	Cyclorphan is an opioid analgesic of the morphinan family that was never marketed. It acts as a μ-opioid receptor (MOR) weak partial agonist or antagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR). The drug was first synthesized in 1964 by scientists at Research Corporation. In clinical trials, it had relatively long duration, good absorption, and provided strong pain relief but produced psychotomimetic effects via KOR activation, so its development was not continued. (en)
dbo:casNumber	4163-15-9
dbo:chEMBL	49269
dbo:fdaUniiCode	U6Z73N36V0
dbo:pubchem	5359966
dbo:thumbnail	wiki-commons:Special:FilePath/cyclorphan_structure.svg?width=300
dbo:wikiPageID	24837552 (xsd:integer)
dbo:wikiPageLength	3598 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1070868364 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Proxorphan dbr:Psychotomimetic dbr:Partial_agonist dbr:Research_Corporation dbr:Δ-opioid_receptor dbc:Cyclopropanes dbc:Phenols dbr:Full_agonist dbr:Morphinan dbr:Nalbuphine dbc:Kappa-opioid_receptor_agonists dbr:Levomethorphan dbr:Levorphanol dbr:Clinical_trial dbr:Receptor_antagonist dbc:Delta-opioid_receptor_agonists dbr:Butorphanol dbr:Analgesic dbc:Morphinans dbr:Oxilorphan dbc:Dissociative_drugs dbc:Synthetic_opioids dbr:Μ-opioid_receptor dbr:Affinity_(pharmacology) dbr:Opioid dbr:Xorphanol dbr:Κ-opioid_receptor
dbp:boilingPoint	458.400000 (xsd:double)
dbp:c	20 (xsd:integer)
dbp:casNumber	4163 (xsd:integer)
dbp:chembl	49269 (xsd:integer)
dbp:chemspiderid	4514407 (xsd:integer)
dbp:density	1.190000 (xsd:double)
dbp:h	27 (xsd:integer)
dbp:iupacName	-3 (xsd:integer)
dbp:meltingPoint	188 (xsd:integer)
dbp:n	1 (xsd:integer)
dbp:o	1 (xsd:integer)
dbp:pubchem	5359966 (xsd:integer)
dbp:smiles	Oc1ccc4c[C@@]25[C@H]CCCC5 (en)
dbp:unii	U6Z73N36V0 (en)
dbp:wikiPageUsesTemplate	dbt:Analgesic-stub dbt:Analgesics dbt:Drugbox dbt:Hallucinogens dbt:Opioidergics dbt:Reflist dbt:Rp dbt:Short_description dbt:Fdacite
dcterms:subject	dbc:Cyclopropanes dbc:Phenols dbc:Kappa-opioid_receptor_agonists dbc:Delta-opioid_receptor_agonists dbc:Morphinans dbc:Dissociative_drugs dbc:Synthetic_opioids
gold:hypernym	dbr:Compound
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Substance100019613 yago:WikicatPhenols umbel-rc:DrugProduct
rdfs:comment	Cyclorphan is an opioid analgesic of the morphinan family that was never marketed. It acts as a μ-opioid receptor (MOR) weak partial agonist or antagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR). The drug was first synthesized in 1964 by scientists at Research Corporation. In clinical trials, it had relatively long duration, good absorption, and provided strong pain relief but produced psychotomimetic effects via KOR activation, so its development was not continued. (en)
rdfs:label	Cyclorphan (en)
owl:sameAs	freebase:Cyclorphan yago-res:Cyclorphan wikidata:Cyclorphan dbpedia-sh:Cyclorphan dbpedia-sr:Cyclorphan https://global.dbpedia.org/id/4j7ru
prov:wasDerivedFrom	wikipedia-en:Cyclorphan?oldid=1070868364&ns=0
foaf:depiction	wiki-commons:Special:FilePath/cyclorphan_structure.svg
foaf:isPrimaryTopicOf	wikipedia-en:Cyclorphan
is dbo:wikiPageRedirects of	dbr:C20H27NO
is dbo:wikiPageWikiLink of	dbr:Proxorphan dbr:List_of_opioids dbr:Morphinan dbr:Levallorphan dbr:Levomethorphan dbr:Hallucination dbr:C20H27NO dbr:Oxilorphan dbr:Ketorfanol dbr:Opioid dbr:Racemorphan dbr:Xorphanol dbr:Κ-opioid_receptor
is foaf:primaryTopic of	wikipedia-en:Cyclorphan

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