Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                

About: Cystatin

An Entity of Type: protein, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit peptidase enzymes (another term for proteases) belonging to peptidase families C1 (papain family) and C13 (legumain family). They are known to mis-fold to form amyloid deposits and are implicated in several diseases.

Property Value
dbo:abstract
  • The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit peptidase enzymes (another term for proteases) belonging to peptidase families C1 (papain family) and C13 (legumain family). They are known to mis-fold to form amyloid deposits and are implicated in several diseases. (en)
  • 시스타틴(cystatin)은 하나의 시퀀스 상동성과 공통의 알파 나선 3차 구조를 공유하는 가수 분해 억제제이다. 시스타틴은 , , 히스티딘이 풍부한 및 크리스타틴 관련 단백질과 유사성을 보인다. 시스타틴은 주로 펜티디아제족 C1 및 C13에 속한 펜티디아제 효소를 억제한다. (ko)
  • Le cistatine sono una famiglia di proteine capaci di inibire le cistein proteasi. (it)
  • Цистатины — семейство белков-ингибиторов сериновой протеазы, гомологичных по структуре куриному цистатину. Типичный цистатин содержит около 115 аминокислот, имеет 4 эволюционно консервативных цистеиновых остатка, образующих две дисульфидные связи. Цистатины могут подвергаться гликозилированию и/или фосфорилированию. (ru)
dbo:symbol
  • Prot_inh_cystat
dbo:thumbnail
dbo:wikiPageExternalLink
dbo:wikiPageID
  • 5979024 (xsd:integer)
dbo:wikiPageLength
  • 7725 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1106226413 (xsd:integer)
dbo:wikiPageWikiLink
dbp:caption
  • Crystal structure of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata from PDB entry . (en)
dbp:date
  • March 2017 (en)
dbp:interpro
  • IPR000010 (en)
dbp:name
  • Proteinase inhibitor I25, cystatin (en)
dbp:pfam
  • PF00031 (en)
dbp:pfamClan
  • CL0121 (en)
dbp:prosite
  • PDOC00259 (en)
dbp:reason
  • Why is this important? Context for this statement is absent. (en)
dbp:smart
  • SM00043 (en)
dbp:symbol
  • Prot_inh_cystat (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit peptidase enzymes (another term for proteases) belonging to peptidase families C1 (papain family) and C13 (legumain family). They are known to mis-fold to form amyloid deposits and are implicated in several diseases. (en)
  • 시스타틴(cystatin)은 하나의 시퀀스 상동성과 공통의 알파 나선 3차 구조를 공유하는 가수 분해 억제제이다. 시스타틴은 , , 히스티딘이 풍부한 및 크리스타틴 관련 단백질과 유사성을 보인다. 시스타틴은 주로 펜티디아제족 C1 및 C13에 속한 펜티디아제 효소를 억제한다. (ko)
  • Le cistatine sono una famiglia di proteine capaci di inibire le cistein proteasi. (it)
  • Цистатины — семейство белков-ингибиторов сериновой протеазы, гомологичных по структуре куриному цистатину. Типичный цистатин содержит около 115 аминокислот, имеет 4 эволюционно консервативных цистеиновых остатка, образующих две дисульфидные связи. Цистатины могут подвергаться гликозилированию и/или фосфорилированию. (ru)
rdfs:label
  • Cystatin (en)
  • Cistatina (it)
  • 시스타틴 (ko)
  • Цистатины (ru)
  • 胱抑素 (zh)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License