H3T3P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 3rd threonine residue of the histone H3 protein. Pre-existing vs newly generated H3 is distinguished by phosphorylation at threonine 3. H3T3P separates sister chromatids enriched with diverse pools of H3 in order to coordinate asymmetric segregation of "old" H3 into germ stem cells and that male germline activity requires tight regulation of H3T3 phosphorylation.
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