Isaac de Sequeira Samuda or Isaac de Sequeyra Samuda (born 1681, d. 1729) was a British physician and poet. He was of Portuguese-Jewish descent and was the first member of the Samuda family to settle in Britain. He was the first Jew to be elected a Fellow of the Royal Society (in 1727). In 1728, he gave an oration at the funeral of Haham David Nieto.