Joseph Eisele (1834 – March 6, 1868), known as The Parkersburg Murderer, was a German serial killer who killed three fellow emigrants in Parkersburg and Wheeling, West Virginia from June to December 1867 in apparent robberies. After a failed attempt on a would-be fourth victim, Eisele was arrested and linked to the previous crimes, to which he subsequently admitted in a written confession published after his hanging in 1868.