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About: LCCL domain

An Entity of Type: protein, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Cochlin (Coch-5b2) and Lgl1 (CRISPLD2). It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with , C-type lectin domains, , CUB domains, or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding. LCCL exhibits a novel fold.

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  • In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Cochlin (Coch-5b2) and Lgl1 (CRISPLD2). It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with , C-type lectin domains, , CUB domains, or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding. LCCL exhibits a novel fold. Some proteins known to contain a LCCL domain include Limulus factor C, an LPS endotoxin-sensitive trypsin type serine protease which serves to protect the organism from bacterial infection; vertebrate cochlear protein cochlin or coch-5b2 (Cochlin is probably a secreted protein, mutations affecting the LCCL domain of coch-5b2 cause the deafness disorder DFNA9 in humans); and mammalian late gestation lung protein Lgl1, contains two tandem copies of the LCCL domain. (en)
dbo:symbol
  • LCCL
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dbo:wikiPageID
  • 34577796 (xsd:integer)
dbo:wikiPageLength
  • 3647 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 997567242 (xsd:integer)
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dbp:caption
  • LCCL domain in human Cochlin (en)
dbp:cath
  • 1 (xsd:integer)
dbp:interpro
  • IPR004043 (en)
dbp:name
  • LCCL (en)
dbp:pfam
  • PF03815 (en)
dbp:pfamClan
  • CL0513 (en)
dbp:scop
  • 1 (xsd:integer)
dbp:symbol
  • LCCL (en)
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rdfs:comment
  • In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Cochlin (Coch-5b2) and Lgl1 (CRISPLD2). It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with , C-type lectin domains, , CUB domains, or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding. LCCL exhibits a novel fold. (en)
rdfs:label
  • LCCL domain (en)
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