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- NamiRNAs are a type of miRNAs present in the nucleus, which can activate gene expression by binding to the enhancer, and therefore were named nuclear activating miRNAs (NamiRNAs), such as miR-24-1 and miR-26. These miRNAs loci are enriched with epigenetic markers that display enhancer activity like histone H3K27ac, P300/CBP, and high-sensitivity loci. These NamiRNAs are able to activate the related enhancers and co-work with them to up-regulate the expression of neighboring genes. NamiRNAs are able to promote global gene transcription by binding their targeted enhancers in whole genome level. Canonically, miRNAs silence gene expression through binding to the complementary sequences of their targeted mRNAs that are often located in the 3’UTR in the cytoplasm since the first miRNA lin-4 has been found by Ambros Victor. As so far, most studies of miRNAs have focused on those in the cytoplasm. Other than the classical theory that miRNAs down-regulate target genes by binding to the 3’UTR of mRNA, it has also been shown that miRNAs could upregulate gene expression in certain cases, just like RNAa phenomenon, which describes a picture that miRNAs can bind to the promoter of the target genes to facilitate gene transcriptions. Moreover, Vasudevan S. et al. held that miRNAs display a pattern of up-regulation on gene transcription together with AGO2 and FXR1. The discovery of NamiRNAs showcases a complementary regulatory mechanism of miRNAs, demonstrating their different roles in the nucleus and cytoplasm. (en)
- namiRNAs，即核激活小分子核糖核酸（英語：nuclear activating miRNAs）是一类作用于细胞核中的小分子核糖核酸（miRNAs），可通过结合增强子激活基因表达，例子有miR-24-1和miR-26等。 (zh)
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- namiRNAs，即核激活小分子核糖核酸（英語：nuclear activating miRNAs）是一类作用于细胞核中的小分子核糖核酸（miRNAs），可通过结合增强子激活基因表达，例子有miR-24-1和miR-26等。 (zh)
- NamiRNAs are a type of miRNAs present in the nucleus, which can activate gene expression by binding to the enhancer, and therefore were named nuclear activating miRNAs (NamiRNAs), such as miR-24-1 and miR-26. These miRNAs loci are enriched with epigenetic markers that display enhancer activity like histone H3K27ac, P300/CBP, and high-sensitivity loci. These NamiRNAs are able to activate the related enhancers and co-work with them to up-regulate the expression of neighboring genes. NamiRNAs are able to promote global gene transcription by binding their targeted enhancers in whole genome level. (en)
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- NamiRNAs (en)
- NamiRNAs (zh)
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