The Norfolk Anti- Inoculation Riot on June 27, 1768 was part of a series of riots across the English Colonies in the New World surrounding inoculation against smallpox. Many inhabitants of the colonies were against this relatively new approach to build immunity against smallpox. Inhabitants were afraid that inoculation would infect and kill uninfected communities, but they also objected for political reasons. The riot on June 27, 1768 in Norfolk, Virginia consisted of an anti-inoculation mob invading a plantation where inoculated families resided, ending in the mob driving the families into the local pest house.
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