About: Oclacitinib

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Oclacitinib (brand name Apoquel) is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. It inhibits signal transduction when the JAK is activated and thus helps downregulate expression of inflammatory cytokines. While oclacitinib is effective, its long-term safety is currently unknown. Oclacitinib was approved by the FDA in 2013.

Property	Value
dbo:abstract	Oclacitinib (brand name Apoquel) is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. It inhibits signal transduction when the JAK is activated and thus helps downregulate expression of inflammatory cytokines. While oclacitinib is effective, its long-term safety is currently unknown. Oclacitinib was approved by the FDA in 2013. (en)
dbo:alternativeName	Apoquel (en)
dbo:bioavailability	89.000000 (xsd:float)
dbo:casNumber	1208319-26-9
dbo:chEMBL	2103874
dbo:class	dbr:JAK_inhibitor
dbo:fdaUniiCode	99GS5XTB51
dbo:kegg	D10141
dbo:pubchem	44631938
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dbp:atcPrefix	D11 (en)
dbp:atcSuffix	AH90 (en)
dbp:atcvet	yes (en)
dbp:bioavailability	89.0 (dbd:perCent)
dbp:c	15 (xsd:integer)
dbp:casNumber	1208319 (xsd:integer)
dbp:chembl	2103874 (xsd:integer)
dbp:chemspiderid	28528036 (xsd:integer)
dbp:class	dbr:JAK_inhibitor
dbp:eliminationHalfLife	-18720.0 (dbd:second)
dbp:excretion	Mostly liver (en)
dbp:h	23 (xsd:integer)
dbp:image	Apoquel bottle.jpg (en)
dbp:iupacName	N-Methyl{trans-4-[methylamino]cyclohexyl}methanesulfonamide (en)
dbp:kegg	D10141 (en)
dbp:legalStatus	Rx-only (en)
dbp:metabolism	dbr:Liver
dbp:n	5 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:proteinBound	66.300000 (xsd:double)
dbp:pubchem	44631938 (xsd:integer)
dbp:routesOfAdministration	By mouth (en)
dbp:s	1 (xsd:integer)
dbp:smiles	CNSC[C@@H]1CC[C@H]Nc2[nH]cnc3nccc23 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	HJWLJNBZVZDLAQ-HAQNSBGRSA-N (en)
dbp:synonyms	PF-03394197 (en)
dbp:tradename	Apoquel (en)
dbp:unii	99 (xsd:integer)
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dcterms:subject	dbc:Pyrrolopyrimidines dbc:Sulfonamides dbc:Non-receptor_tyrosine_kinase_inhibitors dbc:Veterinary_drugs
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rdfs:comment	Oclacitinib (brand name Apoquel) is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. It inhibits signal transduction when the JAK is activated and thus helps downregulate expression of inflammatory cytokines. While oclacitinib is effective, its long-term safety is currently unknown. Oclacitinib was approved by the FDA in 2013. (en)
rdfs:label	Oclacitinib (en)
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