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The Phage 21 S (P21 Holin) Family (TC# 1.E.1) is a member of the Holin Superfamily II. The Bacteriophage P21 Lysis protein S holin (TC# 1.E.1.1.1) is the prototype for class II holins. Lysis S proteins have two transmembrane segments (TMSs), with both the N- and C-termini on the cytoplasmic side of the inner membrane. TMS1 may be dispensable for function. A representative list of proteins belonging to the P21 holin family can be found in the Transporter Classification Database.

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  • The Phage 21 S (P21 Holin) Family (TC# 1.E.1) is a member of the Holin Superfamily II. The Bacteriophage P21 Lysis protein S holin (TC# 1.E.1.1.1) is the prototype for class II holins. Lysis S proteins have two transmembrane segments (TMSs), with both the N- and C-termini on the cytoplasmic side of the inner membrane. TMS1 may be dispensable for function. A homologue of the P21 holin is the holin of bacteriophage H-19B (TC# 1.E.1.1.3). The gene encoding it has been associated with the Shiga-like Toxin I gene in E. coli. It may function in toxin export as has been proposed for the X. nematophila holin-1 (TC #1.E.2.1.4). A representative list of proteins belonging to the P21 holin family can be found in the Transporter Classification Database. (en)
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  • 49720403 (xsd:integer)
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  • 1043901600 (xsd:integer)
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dbp:date
  • 2016-03-10 (xsd:date)
dbp:source
  • Transporter Classification Database (en)
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  • http://www.tcdb.org/search/result.php?tc=1.E.1|sourcearticle=1.E.1 The P21 Holin S Family (en)
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  • The Phage 21 S (P21 Holin) Family (TC# 1.E.1) is a member of the Holin Superfamily II. The Bacteriophage P21 Lysis protein S holin (TC# 1.E.1.1.1) is the prototype for class II holins. Lysis S proteins have two transmembrane segments (TMSs), with both the N- and C-termini on the cytoplasmic side of the inner membrane. TMS1 may be dispensable for function. A representative list of proteins belonging to the P21 holin family can be found in the Transporter Classification Database. (en)
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  • P21 holin family (en)
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