About: Phi11 holin family

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The Phi11 Holin (φ11 Holin) Family (TC# 1.E.11) constitutes the Holin Superfamily I. One characterized member of this family, pneumococcal EJ-1 phage holin (EJh; TC# 1.E.11.1.3), is a hydrophobic peptide of 85 amino acyl residues in length (aas) with 2 putative transmembrane segments (TMSs) displaying lethal inner membrane disruptive activity. The synthetic N-terminal TMS flanked by its N-terminal positively charged residues folds into a transmembrane α-helix that increases the membrane permeability. Oligomeric channels of various sizes form depending on the peptide to lipid ratio. By atomic force microscopy, peptide-induced membrane holes can be seen.

Property	Value
dbo:abstract	The Phi11 Holin (φ11 Holin) Family (TC# 1.E.11) constitutes the Holin Superfamily I. One characterized member of this family, pneumococcal EJ-1 phage holin (EJh; TC# 1.E.11.1.3), is a hydrophobic peptide of 85 amino acyl residues in length (aas) with 2 putative transmembrane segments (TMSs) displaying lethal inner membrane disruptive activity. The synthetic N-terminal TMS flanked by its N-terminal positively charged residues folds into a transmembrane α-helix that increases the membrane permeability. Oligomeric channels of various sizes form depending on the peptide to lipid ratio. By atomic force microscopy, peptide-induced membrane holes can be seen. A representative list of proteins belonging to the φ11 holin family can be found in the Transporter Classification Database. (en)
dbo:wikiPageExternalLink	https://www.wikigenes.org/e/gene/e/1262156.html http://www.sciencedirect.com/science/article/pii/S037811190200481X http://www.sciencedirect.com/science/article/pii/S1567134813001718 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426991 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815265 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127328 https://www.ncbi.nlm.nih.gov/pubmed/16569839 https://www.ncbi.nlm.nih.gov/pubmed/17718845 https://www.ncbi.nlm.nih.gov/pubmed/20963614 https://www.ncbi.nlm.nih.gov/pubmed/21418544 https://www.ncbi.nlm.nih.gov/pubmed/9246739 https://www.ncbi.nlm.nih.gov/pubmed/9627962 https://www.worldcat.org/issn/0008-4166 https://www.worldcat.org/issn/0066-4804 https://www.worldcat.org/issn/0266-8254 https://www.worldcat.org/issn/1432-8798 https://www.worldcat.org/issn/1751-7915 http://www.tcdb.org/search/result.php%3Ftc=1.E.11 http://www.tcdb.org/search/result.php%3Ftc=1.E.11%7Csourcearticle=1.E.11 http://www.tcdb.org/search/result.php%3Ftc=1.E.11.1.3 http://www.tcdb.org/search/result.php%3Ftc=1.E.11.3 https://www.worldcat.org/issn/0378-1097
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dbo:wikiPageWikiLink	dbr:PubMed_Central dbc:Protein_families dbr:Lysin dbc:Holins dbr:International_Standard_Serial_Number dbr:Holin dbr:Holin_superfamily_I dbr:Digital_object_identifier dbr:PubMed_Identifier dbr:Transporter_Classification_Database dbr:Doi:10.1007/s00705-010-0812-z dbr:Doi:10.1016/S0378-1119(02)00481-X dbr:Doi:10.1016/j.meegid.2013.04.022 dbr:Doi:10.1111/j.1472-765X.2007.02190.x dbr:Doi:10.1111/j.1751-7915.2011.00257.x dbr:Doi:10.1128/AAC.50.4.1268-1275.2006
dbp:date	2016-03-10 (xsd:date)
dbp:source	Transporter Classification Database (en)
dbp:sourcepath	http://www.tcdb.org/search/result.php?tc=1.E.11\|sourcearticle=1.E.11 The φ11 Holin Family (en)
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rdfs:comment	The Phi11 Holin (φ11 Holin) Family (TC# 1.E.11) constitutes the Holin Superfamily I. One characterized member of this family, pneumococcal EJ-1 phage holin (EJh; TC# 1.E.11.1.3), is a hydrophobic peptide of 85 amino acyl residues in length (aas) with 2 putative transmembrane segments (TMSs) displaying lethal inner membrane disruptive activity. The synthetic N-terminal TMS flanked by its N-terminal positively charged residues folds into a transmembrane α-helix that increases the membrane permeability. Oligomeric channels of various sizes form depending on the peptide to lipid ratio. By atomic force microscopy, peptide-induced membrane holes can be seen. (en)
rdfs:label	Phi11 holin family (en)
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