About: RTI-177

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

RTI(-4229)-177 (2β-(3-phenylisoxazol-5-yl)-3β-(4-chlorophenyl)tropane, β-CPPIT) is a synthetic stimulant drug from the phenyltropane family, which acts as a DRI with micromolar affinity for the SERT. RTI-177 has an unusually long duration of action of 20 hours or more, substantially longer than the related compound RTI-336 from which it differs in molecular structure only by the absence of a p-methyl group.

Property	Value
dbo:abstract	RTI(-4229)-177 (2β-(3-phenylisoxazol-5-yl)-3β-(4-chlorophenyl)tropane, β-CPPIT) is a synthetic stimulant drug from the phenyltropane family, which acts as a DRI with micromolar affinity for the SERT. RTI-177 has an unusually long duration of action of 20 hours or more, substantially longer than the related compound RTI-336 from which it differs in molecular structure only by the absence of a p-methyl group. "the nonselective monoamine transporter inhibitor RTI-126 and the DAT-selective inhibitors RTI-150 and RTI-336 both had a faster rate of onset (30 min) and a short duration of action (4h). In contrast, the nonselective monoamine transporter inhibitor RTI-112 had a slower rate of onset (30–60 min) and a longer duration of action (10h). The DAT-selective inhibitors RTI-171 and RTI-177 also had slower rates of onset (30–120 min), but RTI-171 had a short duration of action (2.5 h) while RTI-177 had a very long duration of action (20 h)." (en)
dbo:casNumber	170939-95-4 171236-00-3
dbo:chEMBL	298580
dbo:pubchem	9821147
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dbp:c	23 (xsd:integer)
dbp:casNumber	170939 (xsd:integer) 171236 (xsd:integer)
dbp:chembl	298580 (xsd:integer)
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dbp:index2Label	HCl (en)
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dbp:o	1 (xsd:integer)
dbp:pubchem	9821147 (xsd:integer)
dbp:smiles	CN1[C@H]2CC[C@@H]1[C@H]C4=CCC5=CC=CC=C5 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	ZGCYMNJHHKQEGA-KPYOPSEVSA-N (en)
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gold:hypernym	dbr:Drug
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rdfs:comment	RTI(-4229)-177 (2β-(3-phenylisoxazol-5-yl)-3β-(4-chlorophenyl)tropane, β-CPPIT) is a synthetic stimulant drug from the phenyltropane family, which acts as a DRI with micromolar affinity for the SERT. RTI-177 has an unusually long duration of action of 20 hours or more, substantially longer than the related compound RTI-336 from which it differs in molecular structure only by the absence of a p-methyl group. (en)
rdfs:label	RTI-177 (en)
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is foaf:primaryTopic of	wikipedia-en:RTI-177

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