About: Rifalazil

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Rifalazil (also known as KRM-1648 and AMI-1648) is an antibiotic substance that kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is used as treatments for many different diseases. Of the most common are Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB). Using rifalazil and the effects that coincide with taking rifalazil for treating a bacterial disease vary from person to person, as does any drug put into the human body. Food interactions and genetic variation are a few causes for the variation in side effects from the use of rifalazil. Its development was terminated in 2013 due to severe side effects.

Property	Value
dbo:abstract	Rifalazil (also known as KRM-1648 and AMI-1648) is an antibiotic substance that kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is used as treatments for many different diseases. Of the most common are Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB). Using rifalazil and the effects that coincide with taking rifalazil for treating a bacterial disease vary from person to person, as does any drug put into the human body. Food interactions and genetic variation are a few causes for the variation in side effects from the use of rifalazil. Its development was terminated in 2013 due to severe side effects. (en)
dbo:iupacName	(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,12,21,23-tetrahydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-1,6,15-trioxo-1,2-dihydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate (en) (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-Tetrahydroxy-30-(4-isobutyl-1-piperazinyl)-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,37-trioxo-8,27,38-trioxa-24,34-diazahexacyclo[23.11;.1.14,7.05,36.026,35.028,33]octatriaconta-1(36),2,4,9,19,21,25,28,30,32,34-undecaen-13-yl acetate (en)
dbo:thumbnail	wiki-commons:Special:FilePath/Rifalazil.svg?width=300
dbo:wikiPageID	37700662 (xsd:integer)
dbo:wikiPageLength	8788 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1106499934 (xsd:integer)
dbo:wikiPageWikiLink	dbc:Anti-tuberculosis_drugs dbr:Methicillin-resistant_Staphylococcus_aureus dbr:Antibiotic dbr:Vancomycin dbr:In_vitro dbc:Abandoned_drugs dbc:Heterocyclic_compounds_with_4_rings dbc:Phenylpiperazines dbc:Rifamycin_antibiotics dbr:Leprosy dbr:Clostridium_difficile_colitis dbr:Tuberculosis dbr:HIV dbr:Half-life dbr:Trachoma dbr:Chlamydia_infection dbr:Buruli_ulcer dbr:RNA_polymerase dbr:Chlamydia_(bacterium)
dbp:imagefile	Rifalazil.svg (en)
dbp:imagesize	320 (xsd:integer)
dbp:iupacname	-5122123 (xsd:integer)
dbp:systematicname	-2151732 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Antimycobacterials dbt:Authority_control dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Short_description dbt:Chembox_Explosive dbt:Chembox_Pharmacology dbt:Chembox_Related dbt:Chembox_Structure dbt:Fdacite dbt:Medcn dbt:Nucleic_acid_inhibitors
dct:subject	dbc:Anti-tuberculosis_drugs dbc:Abandoned_drugs dbc:Heterocyclic_compounds_with_4_rings dbc:Phenylpiperazines dbc:Rifamycin_antibiotics
gold:hypernym	dbr:Antibiotic
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:ChemicalCompound dbo:Drug yago:Substance100020090 yago:WikicatDrugs
rdfs:comment	Rifalazil (also known as KRM-1648 and AMI-1648) is an antibiotic substance that kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is used as treatments for many different diseases. Of the most common are Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB). Using rifalazil and the effects that coincide with taking rifalazil for treating a bacterial disease vary from person to person, as does any drug put into the human body. Food interactions and genetic variation are a few causes for the variation in side effects from the use of rifalazil. Its development was terminated in 2013 due to severe side effects. (en)
rdfs:label	Rifalazil (en)
owl:sameAs	freebase:Rifalazil yago-res:Rifalazil wikidata:Rifalazil dbpedia-sh:Rifalazil dbpedia-sr:Rifalazil https://global.dbpedia.org/id/4uGeB
prov:wasDerivedFrom	wikipedia-en:Rifalazil?oldid=1106499934&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Rifalazil.svg
foaf:isPrimaryTopicOf	wikipedia-en:Rifalazil
is dbo:wikiPageWikiLink of	dbr:Rifamycin dbr:Clostridioides_difficile_infection dbr:List_of_drugs:_Rf–Rz
is foaf:primaryTopic of	wikipedia-en:Rifalazil

This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License