About: Ru360

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Ru360 is an oxo-bridged dinuclear ruthenium ammine complex with an absorption spectrum maximum at 360 nm. It is an analog of ruthenium red, a well-known effective inhibitor of the mitochondrial calcium uniporter. Since Ru360 inhibits the flow of calcium into mitochondria, which can prevent the opening of the mitochondrial permeability transition pore, it has been investigated as a therapeutic treatment for stroke and heart attack.

Property	Value
dbo:abstract	Ru360 is an oxo-bridged dinuclear ruthenium ammine complex with an absorption spectrum maximum at 360 nm. It is an analog of ruthenium red, a well-known effective inhibitor of the mitochondrial calcium uniporter. Ru360 was discovered after scientists found that commercial preparations of ruthenium red were often less than 20% pure, and that the crude mixture produced a stronger inhibition than the purified product. This component was later isolated and its structure determined, Ru360 has structural formula (μ-O)[(HCO2)(NH3)4Ru]2Cl3, that is, an oxygen-linked chain only two octahedral ruthenium–ammine units rather than the three of ruthenium red. One of the ruthenium atoms is in a +3 oxidation state, and the other in a +4 oxidation state. In addition to the four ammonia ligands, each ruthenium also has one formate group and there are a total of three chloride ions to balance the charge. In solution, chloride or hydroxide groups displace the formates. Since Ru360 inhibits the flow of calcium into mitochondria, which can prevent the opening of the mitochondrial permeability transition pore, it has been investigated as a therapeutic treatment for stroke and heart attack. (en)
dbo:alternativeName	Ru360; (μ)[(HCO2)(NH3)4Ru]2OCl3; Obftar (en)
dbo:iupacName	azanide;formic acid;ruthenium(5+);trichloride;hydrate (en)
dbo:wikiPageID	49537167 (xsd:integer)
dbo:wikiPageLength	3895 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1094071844 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Calcium dbr:Enzyme_inhibitor dbc:Mixed_valence_compounds dbr:Ruthenium dbc:Chloro_complexes dbc:Ruthenium_complexes dbr:Ruthenium_red dbr:Mitochondrion dbr:Myocardial_infarction dbr:Stroke dbr:Functional_analog_(chemistry) dbc:Formates dbc:Ammine_complexes dbr:Formate dbr:Absorption_spectroscopy dbc:Ion_channel_blockers dbr:Mitochondrial_calcium_uniporter dbr:Mitochondrial_permeability_transition_pore dbr:Octahedral_molecular_geometry dbr:Ammine_complex dbr:Dinuclear
dbp:iupacname	azanide;formic acid;ruthenium;trichloride;hydrate (en)
dbp:othernames	Ru360; [4Ru]2OCl3; Obftar (en)
dbp:wikiPageUsesTemplate	dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist
dcterms:subject	dbc:Mixed_valence_compounds dbc:Chloro_complexes dbc:Ruthenium_complexes dbc:Formates dbc:Ammine_complexes dbc:Ion_channel_blockers
gold:hypernym	dbr:Amine
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound
rdfs:comment	Ru360 is an oxo-bridged dinuclear ruthenium ammine complex with an absorption spectrum maximum at 360 nm. It is an analog of ruthenium red, a well-known effective inhibitor of the mitochondrial calcium uniporter. Since Ru360 inhibits the flow of calcium into mitochondria, which can prevent the opening of the mitochondrial permeability transition pore, it has been investigated as a therapeutic treatment for stroke and heart attack. (en)
rdfs:label	Ru360 (en)
owl:sameAs	yago-res:Ru360 wikidata:Ru360 https://global.dbpedia.org/id/2PUNX
prov:wasDerivedFrom	wikipedia-en:Ru360?oldid=1094071844&ns=0
foaf:isPrimaryTopicOf	wikipedia-en:Ru360
is dbo:wikiPageWikiLink of	dbr:Mitochondrial_calcium_uniporter
is foaf:primaryTopic of	wikipedia-en:Ru360

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