The Rufus River Massacre was a massacre of 30–40 Aboriginal people that took place in 1841 along the Rufus River, in the Central Murray region, after three consecutive ambushes with "overlanders" (stock drovers) on the recently opened overland stock route, which followed an old Aboriginal route. The massacre occurred after an official party, including Protector of Aborigines, Matthew Moorhouse, along with police, was sent out by the Governor of South Australia, George Grey.