About: SymE-SymR toxin-antitoxin system

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The SymE-SymR toxin-antitoxin system consists of a small symbiotic endonuclease toxin, SymE, and a non-coding RNA symbiotic RNA antitoxin, SymR, which inhibits SymE translation. SymE-SymR is a type I toxin-antitoxin system, and is under regulation by the antitoxin, SymR. The SymE-SymR complex is believed to play an important role in recycling damaged RNA and DNA. The relationship and corresponding structures of SymE and SymR provide insight into the mechanism of toxicity and overall role in prokaryotic systems.

Property	Value
dbo:abstract	The SymE-SymR toxin-antitoxin system consists of a small symbiotic endonuclease toxin, SymE, and a non-coding RNA symbiotic RNA antitoxin, SymR, which inhibits SymE translation. SymE-SymR is a type I toxin-antitoxin system, and is under regulation by the antitoxin, SymR. The SymE-SymR complex is believed to play an important role in recycling damaged RNA and DNA. The relationship and corresponding structures of SymE and SymR provide insight into the mechanism of toxicity and overall role in prokaryotic systems. (en)
dbo:symbol	SymE_toxin
dbo:thumbnail	wiki-commons:Special:FilePath/SymR_SScons.png?width=300
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dbo:wikiPageWikiLink	dbr:Proline dbr:Endonuclease/Exonuclease/phosphatase_family dbr:Mole_(unit) dbr:Nucleotide dbr:Antisense_RNA dbr:Antitoxin dbr:Beta_sheet dbr:Beta_turn dbr:DNA dbr:DNA_repair dbr:UniProt dbr:Valine dbr:Downregulation_and_upregulation dbr:In_vitro dbr:Protein_primary_structure dbr:Northern_blot dbr:MRNA dbr:Escherichia_coli_O157:H7 dbr:Genetic_code dbr:Open_reading_frame dbr:Protein_tertiary_structure dbr:Glutamic_acid dbr:Glutamine dbr:Glycine dbr:Mitomycin_C dbr:Leucine dbr:Lysine dbr:Colony-forming_unit dbr:Denaturation_(biochemistry) dbr:Symbiosis dbr:Cell_(biology) dbr:Threonine dbr:Toxic dbr:Transcription_(biology) dbr:Transcription_(genetics) dbr:Translation_(genetics) dbr:Tryptophan dbr:Lon_protease_family dbr:Alanine dbr:Alpha_helix dbr:Amino_acid dbr:Cysteine dbr:Escherichia_coli dbr:Evolution dbr:Overexpression dbc:RNA_antitoxins dbr:Transcription_factor dbr:RNA dbr:Helix-turn-helix dbr:Isoleucine dbr:Stem-loop dbr:Aspartic_acid dbc:Antisense_RNA dbr:Binding_site dbr:Biomolecular_structure dbr:Hok/sok_system dbr:Homology_(biology) dbr:Start_codon dbr:DNA_damage dbr:Methionine dbr:Microgram dbr:SOS_response dbr:Sigma_factor dbr:Repressor_lexA dbr:Five_prime_untranslated_region dbr:Toxin-antitoxin_system dbr:Non-coding_RNA dbr:File:SymE_Toxin.png
dbp:below	https://swissmodel.expasy.org/repository/uniprot/P39394
dbp:caption	Conserved secondary structure of SymR RNA. (en) SymE Toxin of Type I toxin-antitoxin system (en)
dbp:id	RF01809 (en)
dbp:interpro	IPR020883 (en)
dbp:name	SymE Toxin of Type I toxin-antitoxin system (en) SymR (en) SymR antitoxin (en)
dbp:pfam	PF13957 (en)
dbp:prosite	PS51740 (en)
dbp:rfam	RF01809 (en)
dbp:rnaType	dbr:Antisense_RNA
dbp:symbol	SymE_toxin (en) SymR (en)
dbp:taxDomain	E. coli (en)
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dcterms:subject	dbc:RNA_antitoxins dbc:Antisense_RNA
gold:hypernym	dbr:Type
rdf:type	owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659
rdfs:comment	The SymE-SymR toxin-antitoxin system consists of a small symbiotic endonuclease toxin, SymE, and a non-coding RNA symbiotic RNA antitoxin, SymR, which inhibits SymE translation. SymE-SymR is a type I toxin-antitoxin system, and is under regulation by the antitoxin, SymR. The SymE-SymR complex is believed to play an important role in recycling damaged RNA and DNA. The relationship and corresponding structures of SymE and SymR provide insight into the mechanism of toxicity and overall role in prokaryotic systems. (en)
rdfs:label	SymE-SymR toxin-antitoxin system (en)
owl:sameAs	freebase:SymE-SymR toxin-antitoxin system wikidata:SymE-SymR toxin-antitoxin system https://global.dbpedia.org/id/4vQWh
prov:wasDerivedFrom	wikipedia-en:SymE-SymR_toxin-antitoxin_system?oldid=994586045&ns=0
foaf:depiction	wiki-commons:Special:FilePath/SymE_Toxin.png wiki-commons:Special:FilePath/SymR_SScons.png
foaf:isPrimaryTopicOf	wikipedia-en:SymE-SymR_toxin-antitoxin_system
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