About: Tiospirone

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. However, development was halted and it was not marketed. Perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone. It was found to be both more potent and more selective in comparison and was commercialized instead.

Property	Value
dbo:abstract	Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. However, development was halted and it was not marketed. Perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone. It was found to be both more potent and more selective in comparison and was commercialized instead. (en)
dbo:casNumber	87691-91-6
dbo:chEMBL	35057
dbo:fdaUniiCode	35C6UMO5SR
dbo:pubchem	55752
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dbp:eliminationHalfLife	5040.0 (dbd:second)
dbp:excretion	Urine (en)
dbp:h	32 (xsd:integer)
dbp:iupacName	8 (xsd:integer)
dbp:iupharLigand	101 (xsd:integer)
dbp:legalStatus	Development terminated (en)
dbp:metabolism	Hepatic (en)
dbp:n	4 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pubchem	55752 (xsd:integer)
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dbp:title	dbr:Pharmacodynamics
dbp:titlestyle	background:#ccccff (en)
dbp:unii	35 (xsd:integer)
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rdfs:comment	Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. However, development was halted and it was not marketed. Perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone. It was found to be both more potent and more selective in comparison and was commercialized instead. (en)
rdfs:label	Tiospirone (en)
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