William Wyggeston (sometimes spelt William Wigston; ca. 1467 to 1536) was an English wool merchant based in Leicester. He was part of the Wyggeston family, which included at least one other William Wyggeston. Although the family had been influential before, he became extremely wealthy (in 1522 records indicate he paid 22% of the tax levied on Leicester), and became Mayor of the Corporation of Leicester twice, and represented Leicester in the Seventh Parliament of Henry VII.