About: ZK-93423

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil. It is a nonbenzodiazepine GABAA agonist which is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing GABAA receptors equally. It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs. ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor.

Property	Value
dbo:abstract	ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil. It is a nonbenzodiazepine GABAA agonist which is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing GABAA receptors equally. It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs. ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor. (en)
dbo:casNumber	83910-44-5
dbo:chEBI	92593
dbo:chEMBL	1518572
dbo:fdaUniiCode	B6PWX5B47Q
dbo:pubchem	121926
dbo:thumbnail	wiki-commons:Special:FilePath/ZK-93423_structure.png?width=300
dbo:wikiPageID	23442740 (xsd:integer)
dbo:wikiPageLength	7062 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1108122802 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Benzodiazepine dbr:Beta-Carboline dbr:Anticonvulsant dbc:Carboxylate_esters dbc:Ethers dbc:GABAA_receptor_positive_allosteric_modulators dbc:Phenol_ethers dbr:Anxiolytic dbr:ZK-93426 dbr:Muscle_relaxant dbc:Beta-Carbolines dbr:GABAA_receptor dbr:Abecarnil dbr:Agonist dbc:Anxiolytics dbr:Nonbenzodiazepine dbc:Ethyl_esters
dbp:atcPrefix	none (en)
dbp:c	23 (xsd:integer)
dbp:casNumber	83910 (xsd:integer)
dbp:chebi	92593 (xsd:integer)
dbp:chembl	1518572 (xsd:integer)
dbp:chemspiderid	108771 (xsd:integer)
dbp:h	22 (xsd:integer)
dbp:iupacName	ethyl 4--6- -9H-pyrido[5,4-b]indole-3-carboxylate (en)
dbp:iupharLigand	4346 (xsd:integer)
dbp:legalStatus	legal (en)
dbp:n	2 (xsd:integer)
dbp:o	4 (xsd:integer)
dbp:pubchem	121926 (xsd:integer)
dbp:smiles	c3ccccc3COccc2c4[nH]cc2c1COC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	ALBKMJDFBZVHAK-UHFFFAOYSA-N (en)
dbp:unii	B6PWX5B47Q (en)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	451222547 (xsd:integer)
dbp:width	240 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:GABAAR_PAMs dbt:Reflist dbt:Cascite dbt:Drugbankcite dbt:Fdacite dbt:Anxiolytics
dcterms:subject	dbc:Carboxylate_esters dbc:Ethers dbc:GABAA_receptor_positive_allosteric_modulators dbc:Phenol_ethers dbc:Beta-Carbolines dbc:Anxiolytics dbc:Ethyl_esters
gold:hypernym	dbr:Drug
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCarboxylateEsters yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Element114840755 yago:Ester114850483 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:Drug yago:Statement106722453 yago:Substance100019613 yago:WikicatEthers yago:WikicatEthylEsters yago:WikicatPhenolEthers umbel-rc:DrugProduct
rdfs:comment	ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil. It is a nonbenzodiazepine GABAA agonist which is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing GABAA receptors equally. It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs. ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor. (en)
rdfs:label	ZK-93423 (en)
owl:sameAs	freebase:ZK-93423 yago-res:ZK-93423 wikidata:ZK-93423 dbpedia-sh:ZK-93423 dbpedia-sr:ZK-93423 https://global.dbpedia.org/id/4xMX7
prov:wasDerivedFrom	wikipedia-en:ZK-93423?oldid=1108122802&ns=0
foaf:depiction	wiki-commons:Special:FilePath/ZK-93423_structure.png
foaf:isPrimaryTopicOf	wikipedia-en:ZK-93423
is dbo:wikiPageRedirects of	dbr:C23H22N2O4
is dbo:wikiPageWikiLink of	dbr:ZK-93426 dbr:C23H22N2O4 dbr:Nonbenzodiazepine
is foaf:primaryTopic of	wikipedia-en:ZK-93423

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