Günümüzde geliþen teknolojinin bize sunduðu pozitron emisyon tomografi (PET), magnetoensefalograf... more Günümüzde geliþen teknolojinin bize sunduðu pozitron emisyon tomografi (PET), magnetoensefalografi, tek foton emisyon komputerize tomografi (SPECT), bilgisayarlý beyin tomografisi, manyetik rezonans gibi görüntüleme yöntemleri ile birlikte elektroensefalografi (EEG) (uyarýlmýþ potansiyeller ve olaya iliþkin potansiyeller de dahil olmak üzere) sadece araþtýrma amaçlý deðil doðrudan klinik uygulamada yer edinen yöntemlerdir. Bu yazý, EEG ve diðer elektrofizyolojik yöntemlerin þizofrenide kullanýmý üzerine odaklanmýþtýr. Bu alanda klinik kullanýma iliþkin çalýþmalar giderek artmaktadýr (Hughes 1995, Karaman 1996, McCarley ve ark. 1991). Elektrofizyolojik yöntemlerin diðer görüntüleme yöntemlerine göre, bireyin herhangi bir kimyasal ve radyoaktif madde ile karþýlaþmamasý, kolay uygulanýr ve ucuz olmasý gibi bazý avantajlarý vardýr. Beyin yapýlarýnda olasý uzaysal iliþkiyi gösterememesi dezavantajý bulunmaktadýr. Ancak biliþsel süreçlerde zamansal deðiþim sürecini yansýtmasý önemlidir.
Türk psikiyatri dergisi = Turkish journal of psychiatry, 2013
The relationship between homocysteine (HCY) levels and cognitive impairments, particularly execut... more The relationship between homocysteine (HCY) levels and cognitive impairments, particularly executive functions in bipolar disorder (BD), has recently been investigated. However, conflicting results were reported. The aim of the present study is to investigate changes in serum HCY, methionine, vitamine B12 and levels in BD patients are relative to controls and to investigate the relationship between HCY, methionine, vitamin B12, and folate levels and clinical features, cognitive functions and psychosocial functioning in euthymic BD patients and controls. Sixty BD type I euthymic patients and twenty controls were assessed with Global Assessment of Functioning and a battery of neuropsychological tests including the Wisconsin card sorting test, the Rey's auditory verbal learning test, the Cancellation test, Trail making test A, Trail making test B, and the Stroop test. HCY, vitamin B12, methionine and folate levels were measured together after collecting blood samples from both pati...
International Journal of Social Psychiatry, Jan 1, 2012
Major depression (MD) is often marked by an unfavourable course. Education repeatedly was found t... more Major depression (MD) is often marked by an unfavourable course. Education repeatedly was found to be associated with better mental health variables, but longitudinal data are scarce. This evaluation seeks to identify the predictive role of specific aspects of education on the course of depression in a socioculturally defined setting. A sample of 69 unipolar MD outpatients in university and primary health care in Antalya, Turkey were observed naturalistically for a mean 11-month period. The baseline examination included several psychosocial variables, among them the highest attained schooling degree (DEG), possible further but unfulfilled educational aspirations (UEA), and the participants' parental educational level (PEL). The depressive symptomatology was assessed with the HAM-D-17 at baseline and at four-monthly follow-ups. A binary variable differentiated 'non-remissive' from 'remissive' courses, the latter displaying at least temporal partial remissions. Forty-two per cent of the sample displayed a non-remissive one-year course of MD. Half of the participants reported UEA. This was more prevalent among women, and qualitative information added causal gender-specific perceptions. In logistic regression, DEG proved prognostic impact, but was exceeded by the combination of UEA and PEL as the strongest predictor model (Cox & Snell R(2) = 0.217). This remained when controlled for place of examination, gender and initial severity of depression. As risk factors for low education, a pattern of female gender and large family size (itself predicted by rural descent) emerged. Low education proved to be a risk factor for an unfavourable course of MD. Not only actual experienced schooling, but also unfulfilled academic aspirations and a low parental educational level appear to be of crucial impact.
Günümüzde geliþen teknolojinin bize sunduðu pozitron emisyon tomografi (PET), magnetoensefalograf... more Günümüzde geliþen teknolojinin bize sunduðu pozitron emisyon tomografi (PET), magnetoensefalografi, tek foton emisyon komputerize tomografi (SPECT), bilgisayarlý beyin tomografisi, manyetik rezonans gibi görüntüleme yöntemleri ile birlikte elektroensefalografi (EEG) (uyarýlmýþ potansiyeller ve olaya iliþkin potansiyeller de dahil olmak üzere) sadece araþtýrma amaçlý deðil doðrudan klinik uygulamada yer edinen yöntemlerdir. Bu yazý, EEG ve diðer elektrofizyolojik yöntemlerin þizofrenide kullanýmý üzerine odaklanmýþtýr. Bu alanda klinik kullanýma iliþkin çalýþmalar giderek artmaktadýr (Hughes 1995, Karaman 1996, McCarley ve ark. 1991). Elektrofizyolojik yöntemlerin diðer görüntüleme yöntemlerine göre, bireyin herhangi bir kimyasal ve radyoaktif madde ile karþýlaþmamasý, kolay uygulanýr ve ucuz olmasý gibi bazý avantajlarý vardýr. Beyin yapýlarýnda olasý uzaysal iliþkiyi gösterememesi dezavantajý bulunmaktadýr. Ancak biliþsel süreçlerde zamansal deðiþim sürecini yansýtmasý önemlidir.
Türk psikiyatri dergisi = Turkish journal of psychiatry, 2013
The relationship between homocysteine (HCY) levels and cognitive impairments, particularly execut... more The relationship between homocysteine (HCY) levels and cognitive impairments, particularly executive functions in bipolar disorder (BD), has recently been investigated. However, conflicting results were reported. The aim of the present study is to investigate changes in serum HCY, methionine, vitamine B12 and levels in BD patients are relative to controls and to investigate the relationship between HCY, methionine, vitamin B12, and folate levels and clinical features, cognitive functions and psychosocial functioning in euthymic BD patients and controls. Sixty BD type I euthymic patients and twenty controls were assessed with Global Assessment of Functioning and a battery of neuropsychological tests including the Wisconsin card sorting test, the Rey's auditory verbal learning test, the Cancellation test, Trail making test A, Trail making test B, and the Stroop test. HCY, vitamin B12, methionine and folate levels were measured together after collecting blood samples from both pati...
International Journal of Social Psychiatry, Jan 1, 2012
Major depression (MD) is often marked by an unfavourable course. Education repeatedly was found t... more Major depression (MD) is often marked by an unfavourable course. Education repeatedly was found to be associated with better mental health variables, but longitudinal data are scarce. This evaluation seeks to identify the predictive role of specific aspects of education on the course of depression in a socioculturally defined setting. A sample of 69 unipolar MD outpatients in university and primary health care in Antalya, Turkey were observed naturalistically for a mean 11-month period. The baseline examination included several psychosocial variables, among them the highest attained schooling degree (DEG), possible further but unfulfilled educational aspirations (UEA), and the participants' parental educational level (PEL). The depressive symptomatology was assessed with the HAM-D-17 at baseline and at four-monthly follow-ups. A binary variable differentiated 'non-remissive' from 'remissive' courses, the latter displaying at least temporal partial remissions. Forty-two per cent of the sample displayed a non-remissive one-year course of MD. Half of the participants reported UEA. This was more prevalent among women, and qualitative information added causal gender-specific perceptions. In logistic regression, DEG proved prognostic impact, but was exceeded by the combination of UEA and PEL as the strongest predictor model (Cox & Snell R(2) = 0.217). This remained when controlled for place of examination, gender and initial severity of depression. As risk factors for low education, a pattern of female gender and large family size (itself predicted by rural descent) emerged. Low education proved to be a risk factor for an unfavourable course of MD. Not only actual experienced schooling, but also unfulfilled academic aspirations and a low parental educational level appear to be of crucial impact.
Uploads
Papers by Taha Karaman