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BLAD is autosomal recessive genetic disease that affects Holstein breed world wide. It is a disease characterized by reduced expression of the adhesion molecules on neutrophils. The disease is caused by a mutation which replaces adenine... more
BLAD is autosomal recessive genetic disease that affects Holstein breed world wide. It is a disease characterized by reduced expression of the adhesion molecules on neutrophils. The disease is caused by a mutation which replaces adenine at 383 with Guanine that changes amino acid, Aspartic acid to Glycine, leading to the expression of a wrong protein (CD18) that is impaired in function. Blood samples were collected from 42 HF and HF crossbred phenotypically normal bulls maintained at different sperm stations of Gujarat. ...