Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, which includes both ... more Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, which includes both benign and malignant forms. Gestational trophoblastic neoplasia (GTN) includes both benign and malignant tumors of gestational trophoblasts. Placental site trophoblastic disease (PSTT) is a rare and potentially aggressive neoplasm originating from placental intermediate trophoblastic cells (ITC) at the implantation site. PSTT represents an abnormal proliferation of ITCs, which are involved in the embryo's implantation and the placenta's formation. ITCs are different from Cytotrophoblasts (CT) and syncytiotrophoblasts (ST). CTs are villous stem cells with high mitotic activity, while the STs, another villous cell, synthesize the human chorionic gonadotropin (hCG) and form the chorionic villi. The extravillous ITCs have features of the other two cells and are responsible for endometrial invasion and implantation. A 32-year-old female presented with symptoms indicative of a PSTT. Following a thorough diagnostic workup, including imaging and histopathological examination, the diagnosis of a localized PSTT was confirmed. Given the patient's desire for future fertility, a fertility-preserving approach was prioritized. She underwent a localized surgical procedure to excise the tumor while maintaining the integrity of her reproductive organs. Postoperative monitoring showed no evidence of residual disease or metastasis. This case highlights the feasibility and success of fertility-preserving surgery in the management of localized PSTT, emphasizing the importance of individualized treatment planning to balance oncologic control with fertility preservation.
Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, which includes both ... more Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, which includes both benign and malignant forms. Gestational trophoblastic neoplasia (GTN) includes both benign and malignant tumors of gestational trophoblasts. Placental site trophoblastic disease (PSTT) is a rare and potentially aggressive neoplasm originating from placental intermediate trophoblastic cells (ITC) at the implantation site. PSTT represents an abnormal proliferation of ITCs, which are involved in the embryo's implantation and the placenta's formation. ITCs are different from Cytotrophoblasts (CT) and syncytiotrophoblasts (ST). CTs are villous stem cells with high mitotic activity, while the STs, another villous cell, synthesize the human chorionic gonadotropin (hCG) and form the chorionic villi. The extravillous ITCs have features of the other two cells and are responsible for endometrial invasion and implantation. A 32-year-old female presented with symptoms indicative of a PSTT. Following a thorough diagnostic workup, including imaging and histopathological examination, the diagnosis of a localized PSTT was confirmed. Given the patient's desire for future fertility, a fertility-preserving approach was prioritized. She underwent a localized surgical procedure to excise the tumor while maintaining the integrity of her reproductive organs. Postoperative monitoring showed no evidence of residual disease or metastasis. This case highlights the feasibility and success of fertility-preserving surgery in the management of localized PSTT, emphasizing the importance of individualized treatment planning to balance oncologic control with fertility preservation.
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