Objective: To estimate suicidal ideation among schizophrenic patients and compare sociodemographi... more Objective: To estimate suicidal ideation among schizophrenic patients and compare sociodemographic and clinical properties. Method: Sixty patients schizophrenic according to DSM-IV criteria were included in the study. Half the patients were in the acute phase and were inpatients, while the other half were in the stable phase and were outpatients. A semistructured sociodemographic form, the Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS) and Schedule for Assessing the Three Components of Insight were used. Results: Suicidal ideations were found in 12 (20%) patients. The proportion having relationship problems, having attempted suicide in the past, and in the acute phase was higher in the group with suicidal ideations than in the group without suicidal ideations. The mean number of suicide attempts was also higher in the group with suicide ideations. The depression score measured by CDSS was higher in the group with suicidal ideations, while there were no relationships between the scores of positive and negative symptoms, and the degree of insight and suicidal thoughts. Conclusion: The high rate of suicidal ideation in our sample suggests that, when planning treatment and follow-up for these patients, the risk of suicide has to be determined and protective measures have to be taken. It suggests that determining depression routinely with scales that can be used easily, like CDSS, can be useful for these patients.
Abstract Background and Objectives To investigate the clinical characteristics of adolescents wit... more Abstract Background and Objectives To investigate the clinical characteristics of adolescents with early-onset full psychotic disorders either with Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) or DRD2/ANKK1 Taq1A (rs1800497) polymorphisms. Method 101 cases with early-onset schizophrenia (EOS) or other psychotic spectrum disorders (SSD) and 150 healthy controls were included in the current study. Using the Positive and Negative Symptom Scale (PANSS), patient subgroups were compared for their psychotic symptoms, age-onset, duration of untreated illness, and family history of psychiatric disorders. The real-time polymerase chain reaction (RT-PCR) was implemented for genotyping procedures. Results Study groups and patient subgroups were similar regarding their sociodemographic characteristics (16.4 ± 2.6 years, 62.2% male for all participants). Results did not reveal any difference between patients and healthy controls for DRD2/ANKK1 Taq1A and BDNF Val66Met genotypes. Patients with A1A2 (Gly/Lys) allele reported higher rates of substance use compared to A2A2 (Glu/Glu) counterparts. Other clinical variables were found similar. EOS/SSD group with Val66Met heterozygote allele revealed lower levels of negative symptoms than Val/Val homozygotes. Conversely, the age onset of full psychotic disorder, total positive symptom score, and total general psychopathology score of PANSS were found comparable between Val/Met and Val/Val groups. In the logistic regression model, Glu/Lys genotypes remained significant for the presence of substance use. Conclusion The interaction between substance use and the DRD2 gene should be investigated for the development of early-onset psychotic disorders. BDNF Val66Met polymorphism also could be a disease-modifying factor for the presence of negative symptoms.
Objective: Schizophrenia is a significant and common disorder. In neural development, it has been... more Objective: Schizophrenia is a significant and common disorder. In neural development, it has been noted that prenatal ve perinatal disruptions result in neuropsychological deficits and these deficits might result in early-onset behavioral problems and criminal behaviors.Taking all these previously completed studies into consideration, we have designed a study to find out whether or not there would be any difference caused by previously acquired viral infections between criminal patients and non-criminal ones. On the other hand, this study compares the socio-demographic characteristics. Methods: Two groups from criminal services and acute psychiatry services parti-cipated in the study; the first group consists of 97 male schizophrenic patients with criminal acts and the second group consists of 105 male schizophrenic patients with no criminal acts. ELISA method was used to detect HSV 1-2, and CMV infections. Sociodemographic characteristics of the patients were obtained by scanning patients' files and/or consulting their relatives. Results: The present study was conducted with 202 male patients at the ages of 20 to 76 with a mean age of 40.36±11.33. A logistic regression analysis was conducted by assuming the variables observed as statistically significant or near statistically significant effects as independent variables and the crime commitment status as a dependent variable, in univariant committing crime analyses. Conclusions: These results indicate a statistical significance in some parameters among sociodemographics of schizophrenic patients with criminal acts and without criminal acts as well as non-existence of any significant association between HSV 1-2, and CMV infections and crime commitment in schizophrenic patients.
Herbal medicine is widely used as alternative and complementary health practice. At recent years,... more Herbal medicine is widely used as alternative and complementary health practice. At recent years, the use of herbal medicine is increased in psychiatric practise. In this review it was mentioned in which conditions the herbal medicine were used, the adverse effects of herbals, the interactions between other drugs and the essential points were emphasized that the clinicians should keep in mind.
Amaç: Bu çalışmada, dikkat eksikliği hiperaktivite bozukluğu (DEHB) tanısı ile izlenen çocukların... more Amaç: Bu çalışmada, dikkat eksikliği hiperaktivite bozukluğu (DEHB) tanısı ile izlenen çocukların anne ve babalarındaki yaşam boyu psikopatolojinin DSM-IV ölçütlerine göre araştırılması amaçlanmıştır. Yöntem: Çalışma grupları 118 dikkat eksikliği hiperaktivite bozukluğu (DEHB) ve 115 enürezis nokturna (EN) tanıları ile izlenen çocukların ebeveynlerinden oluşturulmuştur. Değerlendirmeler için yarı yapılandırılmış sosyodemografik form, Turgay DEHB ölçeği ve SCID-I kullanılmıştır. Bulgular: DEHB tanılı çocukların ebeveynlerde duygudurum bozukluğu (%12.3) ve anksiyete bozukluğu (%8.1) bulunma oranı EN tanılı çocukların ebeveynlerinde bulunma oranından (sırasıyla %4.8, %3.5) istatistiksel olarak anlamlı derecede yüksek bulunmuştur. DEHB tanılı çocukların ebeveynlerinden onaltısı (%6.8) erişkin tip DEHB tanı ölçütlerini doldurmuştur. Erişkin DEHB tanısı alanların %62.5 i kadındır. Erişkin tip DEHB tanısı alanların %12.5’inde duygudurum bozukluğu ve %25’inde anksiyete bozukluğu (çoğunlukla...
Objective: In this study by using factör analizing method we search for phenomenologic subtypes o... more Objective: In this study by using factör analizing method we search for phenomenologic subtypes of mania. Method: In this study we included 75 patient according to who meat the chriterias of DSM IV bipolar disease (new episod-mania-mixt) by using SCID-I. Half sttuctured question form used to work on social demographi-cal&clinical sign, YMDÖ, PANSS, MADRS, CGI. In this study we excluded patient who has mania due to general medical condition, mania because of alcohol and drug abuse, nörological diseased patients, MR-patients& patient who is not educated in order to deside the level of disease we use YMDÖ, PANSS, MADRS, CGI. Conclusion: In our study; according to literature, more than clasical view of mania disforia, high PMA, psikosis subtypes were found high amount.
The Israel journal of psychiatry and related sciences, 2006
The prevalence of antisocial personality disorder (ASPD) in treatment-seeking Turkish substance d... more The prevalence of antisocial personality disorder (ASPD) in treatment-seeking Turkish substance dependent patients and the relationship of ASPD with clinical characteristics were studied. Participants were 132 inpatients with substance dependence according to the Structured Clinical Interview for DSM-IV (SCID-I), Turkish version. The clinician applied a semi-structured socio-demographic form, SCID-I, SCID-II, Childhood Abuse and Neglect Questionnaire (CANQ), Michigan Alcoholism Screening Test (MAST), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Among the 132 substance dependent patients, 31 (23.5%) had ASPD diagnosis and 56 (42.4%) had no personality disorder or personality traits. Rate of childhood physical abuse, childhood verbal abuse, childhood neglect, suicide attempt history, self-destructive behavior and lifetime major depression were higher among patients with ASPD. Also mean scores of BDI, BAI and MAST were higher among patients with ASPD. The high rat...
BACKGROUND/AIM One of the risk factors for increasing psychotic disorders is the use of cannabis.... more BACKGROUND/AIM One of the risk factors for increasing psychotic disorders is the use of cannabis. It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. We aimed to understand the role of cannabis in the etiology of schizophrenia with and without pre-morbid usage. PATIENTS AND METHODS The study group consisted of 80 male patients and genotyping of COMT enzyme Val158Met gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS It was found that the Val/Val genotype is significantly higher in patients with premorbid cannabis use (88.9%) compared to patients without pre-morbid cannabis use (68.4%). Also, the mean total positive and negative syndrome scale (PANSS) score seen in the Val/Val genotype group is significantly higher than the scores of the patients with the Met allele. CONCLUSION The findings from this s...
Objective: To estimate suicidal ideation among schizophrenic patients and compare sociodemographi... more Objective: To estimate suicidal ideation among schizophrenic patients and compare sociodemographic and clinical properties. Method: Sixty patients schizophrenic according to DSM-IV criteria were included in the study. Half the patients were in the acute phase and were inpatients, while the other half were in the stable phase and were outpatients. A semistructured sociodemographic form, the Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS) and Schedule for Assessing the Three Components of Insight were used. Results: Suicidal ideations were found in 12 (20%) patients. The proportion having relationship problems, having attempted suicide in the past, and in the acute phase was higher in the group with suicidal ideations than in the group without suicidal ideations. The mean number of suicide attempts was also higher in the group with suicide ideations. The depression score measured by CDSS was higher in the group with suicidal ideations, while there were no relationships between the scores of positive and negative symptoms, and the degree of insight and suicidal thoughts. Conclusion: The high rate of suicidal ideation in our sample suggests that, when planning treatment and follow-up for these patients, the risk of suicide has to be determined and protective measures have to be taken. It suggests that determining depression routinely with scales that can be used easily, like CDSS, can be useful for these patients.
Abstract Background and Objectives To investigate the clinical characteristics of adolescents wit... more Abstract Background and Objectives To investigate the clinical characteristics of adolescents with early-onset full psychotic disorders either with Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) or DRD2/ANKK1 Taq1A (rs1800497) polymorphisms. Method 101 cases with early-onset schizophrenia (EOS) or other psychotic spectrum disorders (SSD) and 150 healthy controls were included in the current study. Using the Positive and Negative Symptom Scale (PANSS), patient subgroups were compared for their psychotic symptoms, age-onset, duration of untreated illness, and family history of psychiatric disorders. The real-time polymerase chain reaction (RT-PCR) was implemented for genotyping procedures. Results Study groups and patient subgroups were similar regarding their sociodemographic characteristics (16.4 ± 2.6 years, 62.2% male for all participants). Results did not reveal any difference between patients and healthy controls for DRD2/ANKK1 Taq1A and BDNF Val66Met genotypes. Patients with A1A2 (Gly/Lys) allele reported higher rates of substance use compared to A2A2 (Glu/Glu) counterparts. Other clinical variables were found similar. EOS/SSD group with Val66Met heterozygote allele revealed lower levels of negative symptoms than Val/Val homozygotes. Conversely, the age onset of full psychotic disorder, total positive symptom score, and total general psychopathology score of PANSS were found comparable between Val/Met and Val/Val groups. In the logistic regression model, Glu/Lys genotypes remained significant for the presence of substance use. Conclusion The interaction between substance use and the DRD2 gene should be investigated for the development of early-onset psychotic disorders. BDNF Val66Met polymorphism also could be a disease-modifying factor for the presence of negative symptoms.
Objective: Schizophrenia is a significant and common disorder. In neural development, it has been... more Objective: Schizophrenia is a significant and common disorder. In neural development, it has been noted that prenatal ve perinatal disruptions result in neuropsychological deficits and these deficits might result in early-onset behavioral problems and criminal behaviors.Taking all these previously completed studies into consideration, we have designed a study to find out whether or not there would be any difference caused by previously acquired viral infections between criminal patients and non-criminal ones. On the other hand, this study compares the socio-demographic characteristics. Methods: Two groups from criminal services and acute psychiatry services parti-cipated in the study; the first group consists of 97 male schizophrenic patients with criminal acts and the second group consists of 105 male schizophrenic patients with no criminal acts. ELISA method was used to detect HSV 1-2, and CMV infections. Sociodemographic characteristics of the patients were obtained by scanning patients' files and/or consulting their relatives. Results: The present study was conducted with 202 male patients at the ages of 20 to 76 with a mean age of 40.36±11.33. A logistic regression analysis was conducted by assuming the variables observed as statistically significant or near statistically significant effects as independent variables and the crime commitment status as a dependent variable, in univariant committing crime analyses. Conclusions: These results indicate a statistical significance in some parameters among sociodemographics of schizophrenic patients with criminal acts and without criminal acts as well as non-existence of any significant association between HSV 1-2, and CMV infections and crime commitment in schizophrenic patients.
Herbal medicine is widely used as alternative and complementary health practice. At recent years,... more Herbal medicine is widely used as alternative and complementary health practice. At recent years, the use of herbal medicine is increased in psychiatric practise. In this review it was mentioned in which conditions the herbal medicine were used, the adverse effects of herbals, the interactions between other drugs and the essential points were emphasized that the clinicians should keep in mind.
Amaç: Bu çalışmada, dikkat eksikliği hiperaktivite bozukluğu (DEHB) tanısı ile izlenen çocukların... more Amaç: Bu çalışmada, dikkat eksikliği hiperaktivite bozukluğu (DEHB) tanısı ile izlenen çocukların anne ve babalarındaki yaşam boyu psikopatolojinin DSM-IV ölçütlerine göre araştırılması amaçlanmıştır. Yöntem: Çalışma grupları 118 dikkat eksikliği hiperaktivite bozukluğu (DEHB) ve 115 enürezis nokturna (EN) tanıları ile izlenen çocukların ebeveynlerinden oluşturulmuştur. Değerlendirmeler için yarı yapılandırılmış sosyodemografik form, Turgay DEHB ölçeği ve SCID-I kullanılmıştır. Bulgular: DEHB tanılı çocukların ebeveynlerde duygudurum bozukluğu (%12.3) ve anksiyete bozukluğu (%8.1) bulunma oranı EN tanılı çocukların ebeveynlerinde bulunma oranından (sırasıyla %4.8, %3.5) istatistiksel olarak anlamlı derecede yüksek bulunmuştur. DEHB tanılı çocukların ebeveynlerinden onaltısı (%6.8) erişkin tip DEHB tanı ölçütlerini doldurmuştur. Erişkin DEHB tanısı alanların %62.5 i kadındır. Erişkin tip DEHB tanısı alanların %12.5’inde duygudurum bozukluğu ve %25’inde anksiyete bozukluğu (çoğunlukla...
Objective: In this study by using factör analizing method we search for phenomenologic subtypes o... more Objective: In this study by using factör analizing method we search for phenomenologic subtypes of mania. Method: In this study we included 75 patient according to who meat the chriterias of DSM IV bipolar disease (new episod-mania-mixt) by using SCID-I. Half sttuctured question form used to work on social demographi-cal&clinical sign, YMDÖ, PANSS, MADRS, CGI. In this study we excluded patient who has mania due to general medical condition, mania because of alcohol and drug abuse, nörological diseased patients, MR-patients& patient who is not educated in order to deside the level of disease we use YMDÖ, PANSS, MADRS, CGI. Conclusion: In our study; according to literature, more than clasical view of mania disforia, high PMA, psikosis subtypes were found high amount.
The Israel journal of psychiatry and related sciences, 2006
The prevalence of antisocial personality disorder (ASPD) in treatment-seeking Turkish substance d... more The prevalence of antisocial personality disorder (ASPD) in treatment-seeking Turkish substance dependent patients and the relationship of ASPD with clinical characteristics were studied. Participants were 132 inpatients with substance dependence according to the Structured Clinical Interview for DSM-IV (SCID-I), Turkish version. The clinician applied a semi-structured socio-demographic form, SCID-I, SCID-II, Childhood Abuse and Neglect Questionnaire (CANQ), Michigan Alcoholism Screening Test (MAST), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Among the 132 substance dependent patients, 31 (23.5%) had ASPD diagnosis and 56 (42.4%) had no personality disorder or personality traits. Rate of childhood physical abuse, childhood verbal abuse, childhood neglect, suicide attempt history, self-destructive behavior and lifetime major depression were higher among patients with ASPD. Also mean scores of BDI, BAI and MAST were higher among patients with ASPD. The high rat...
BACKGROUND/AIM One of the risk factors for increasing psychotic disorders is the use of cannabis.... more BACKGROUND/AIM One of the risk factors for increasing psychotic disorders is the use of cannabis. It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. We aimed to understand the role of cannabis in the etiology of schizophrenia with and without pre-morbid usage. PATIENTS AND METHODS The study group consisted of 80 male patients and genotyping of COMT enzyme Val158Met gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS It was found that the Val/Val genotype is significantly higher in patients with premorbid cannabis use (88.9%) compared to patients without pre-morbid cannabis use (68.4%). Also, the mean total positive and negative syndrome scale (PANSS) score seen in the Val/Val genotype group is significantly higher than the scores of the patients with the Met allele. CONCLUSION The findings from this s...
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