1. The functional capacity of Henle's loop was examined during hypotonic, isotonic and hypert... more 1. The functional capacity of Henle's loop was examined during hypotonic, isotonic and hypertonic extracellular fluid volume expansion. To eliminate a possible role of antidiuretic hormone (ADH) in the alteration of free water excretion, rats with congenital diabetes insipidus were used. The infusion of hypotonic saline resulted in a progressive rise in free water clearance (CH2O) throughout the range of urine flow (V) attained. Similar results were obtained in rats treated chronically with deoxycorticosterone acetate (DOCA). The infusion of isotonic saline (sodium chloride, 154 mmol/l) produced an initial rise in CH2O until V represented 10% of the filtered load, after which CH2O appeared to reach a plateau. The limitation of CH2O was more marked when hypertonic saline was infused. Medullary and papillary non-urea solute (NUS) concentration rose progressively with the increasing concentration of the saline solution infused. 2. The greater fractional sodium excretion (FENa) afte...
... Kidney International 39:2, 336-352. 7. Manuel Martinez-Maldonado, Hector R Cordova. (1990) Ce... more ... Kidney International 39:2, 336-352. 7. Manuel Martinez-Maldonado, Hector R Cordova. (1990) Cellular and molecular aspects of the renal effects of diuretic agents. ... 10. Satoshi Kimura, Yutaka Sato, Hideki Matsubara, Kaoru Shimada, Ken Yamaguchi, Kaoru Abe. ...
Page 1. Copyright 1973. All rights reserved TUBULAR SITES AND MECHANISMS OF DIURETIC ACTION! WADI... more Page 1. Copyright 1973. All rights reserved TUBULAR SITES AND MECHANISMS OF DIURETIC ACTION! WADI N. SUKI, GARABED EKNOYAN, AND MANUEL MARTINEZ-MALDONADO Renal Section, Department of Medicine ...
Excerpt Paracentesis and the administration of diuretics to reduce the ascites of patients with c... more Excerpt Paracentesis and the administration of diuretics to reduce the ascites of patients with cirrhosis of the liver may lead to impaired renal function. To obviate the difficulties inherent in t...
Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high... more Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high in renal medulla as in cortex. Infusion of digoxin, a specific inhibitor of the enzyme, into one renal artery of the dog resulted in unilateral natriuresis, impaired concentrating capacity, and reduction of the enzyme activity in both cortex and medulla. It is suggested that the sodium-potassium adenosine triphosphatase plays an important role in urine concentration mechanisms.
Chronic kidney disease is a worldwide public health problem with an increasing incidence and prev... more Chronic kidney disease is a worldwide public health problem with an increasing incidence and prevalence, poor outcomes, and high cost. Outcomes of chronic kidney disease include not only kidney failure but also complications of ...
It is necessary to attempt to define, within the limits of current knowledge, the minimal number ... more It is necessary to attempt to define, within the limits of current knowledge, the minimal number of tests required for the early detection and characterization of subclinical nephrotoxicity. In the context of this objective, the conclusions of a Subcommittee on Biologic Markers of Urinary Toxicology (1) convened in the United States by the National Research Council are of interest. In this report, emphasis was focused on markers of exposure, effect, and susceptibility. An understanding of the setting of toxicological standards and the ...
The Journal of Alternative and Complementary Medicine, 2015
In accord with the notions of humoralism that prevailed in medieval medicine, therapeutic interve... more In accord with the notions of humoralism that prevailed in medieval medicine, therapeutic interventions, including diuretics, were used to restore the disturbed balance among the four humors of the human body: blood, phlegm, yellow bile, and black bile. Most diuretics were derived from plants. The primary textual reference on herbal diuretics was Dioscorides's De Materia Medica, which was written during the first century CE. The authors reviewed the medieval medical texts written in Persian and Arabic and compiled a list of 135 herbal diuretics used by the medieval medical authorities for treating various ailments. Between the 8th and 11th centuries CE, Middle Eastern physicians systematically reviewed extant books on medicine and pharmacotherapy and compiled new and expanded lists of herbal medicines, diuretics in particular. Furthermore, they introduced new chemical methods of extraction, distillation, and compounding in the use of herbal medicines. Several herbal remedies now are considered as potentially safe and affordable alternatives to chemical pharmaceuticals. Thus, research on medieval herbal therapies may prove to be relevant to the practice of current cardiovascular and renal pharmacotherapy. The authors propose that modern research methods can be employed to determine which of these agents actually are effective as diuretics.
1. The functional capacity of Henle's loop was examined during hypotonic, isotonic and hypert... more 1. The functional capacity of Henle's loop was examined during hypotonic, isotonic and hypertonic extracellular fluid volume expansion. To eliminate a possible role of antidiuretic hormone (ADH) in the alteration of free water excretion, rats with congenital diabetes insipidus were used. The infusion of hypotonic saline resulted in a progressive rise in free water clearance (CH2O) throughout the range of urine flow (V) attained. Similar results were obtained in rats treated chronically with deoxycorticosterone acetate (DOCA). The infusion of isotonic saline (sodium chloride, 154 mmol/l) produced an initial rise in CH2O until V represented 10% of the filtered load, after which CH2O appeared to reach a plateau. The limitation of CH2O was more marked when hypertonic saline was infused. Medullary and papillary non-urea solute (NUS) concentration rose progressively with the increasing concentration of the saline solution infused. 2. The greater fractional sodium excretion (FENa) afte...
... Kidney International 39:2, 336-352. 7. Manuel Martinez-Maldonado, Hector R Cordova. (1990) Ce... more ... Kidney International 39:2, 336-352. 7. Manuel Martinez-Maldonado, Hector R Cordova. (1990) Cellular and molecular aspects of the renal effects of diuretic agents. ... 10. Satoshi Kimura, Yutaka Sato, Hideki Matsubara, Kaoru Shimada, Ken Yamaguchi, Kaoru Abe. ...
Page 1. Copyright 1973. All rights reserved TUBULAR SITES AND MECHANISMS OF DIURETIC ACTION! WADI... more Page 1. Copyright 1973. All rights reserved TUBULAR SITES AND MECHANISMS OF DIURETIC ACTION! WADI N. SUKI, GARABED EKNOYAN, AND MANUEL MARTINEZ-MALDONADO Renal Section, Department of Medicine ...
Excerpt Paracentesis and the administration of diuretics to reduce the ascites of patients with c... more Excerpt Paracentesis and the administration of diuretics to reduce the ascites of patients with cirrhosis of the liver may lead to impaired renal function. To obviate the difficulties inherent in t...
Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high... more Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high in renal medulla as in cortex. Infusion of digoxin, a specific inhibitor of the enzyme, into one renal artery of the dog resulted in unilateral natriuresis, impaired concentrating capacity, and reduction of the enzyme activity in both cortex and medulla. It is suggested that the sodium-potassium adenosine triphosphatase plays an important role in urine concentration mechanisms.
Chronic kidney disease is a worldwide public health problem with an increasing incidence and prev... more Chronic kidney disease is a worldwide public health problem with an increasing incidence and prevalence, poor outcomes, and high cost. Outcomes of chronic kidney disease include not only kidney failure but also complications of ...
It is necessary to attempt to define, within the limits of current knowledge, the minimal number ... more It is necessary to attempt to define, within the limits of current knowledge, the minimal number of tests required for the early detection and characterization of subclinical nephrotoxicity. In the context of this objective, the conclusions of a Subcommittee on Biologic Markers of Urinary Toxicology (1) convened in the United States by the National Research Council are of interest. In this report, emphasis was focused on markers of exposure, effect, and susceptibility. An understanding of the setting of toxicological standards and the ...
The Journal of Alternative and Complementary Medicine, 2015
In accord with the notions of humoralism that prevailed in medieval medicine, therapeutic interve... more In accord with the notions of humoralism that prevailed in medieval medicine, therapeutic interventions, including diuretics, were used to restore the disturbed balance among the four humors of the human body: blood, phlegm, yellow bile, and black bile. Most diuretics were derived from plants. The primary textual reference on herbal diuretics was Dioscorides's De Materia Medica, which was written during the first century CE. The authors reviewed the medieval medical texts written in Persian and Arabic and compiled a list of 135 herbal diuretics used by the medieval medical authorities for treating various ailments. Between the 8th and 11th centuries CE, Middle Eastern physicians systematically reviewed extant books on medicine and pharmacotherapy and compiled new and expanded lists of herbal medicines, diuretics in particular. Furthermore, they introduced new chemical methods of extraction, distillation, and compounding in the use of herbal medicines. Several herbal remedies now are considered as potentially safe and affordable alternatives to chemical pharmaceuticals. Thus, research on medieval herbal therapies may prove to be relevant to the practice of current cardiovascular and renal pharmacotherapy. The authors propose that modern research methods can be employed to determine which of these agents actually are effective as diuretics.
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