Books by Dr. Harsha Vardhan Reddy Kasireddy
Papers by Dr. Harsha Vardhan Reddy Kasireddy
RSC Adv., 2014
A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents ... more A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents has been developed. Utilizing this protocol a variety of 2-aminoazole derivatives were synthesized in moderate to good yields. The methodology is operationally simple and it provides potentially useful products by using an inexpensive recyclable catalytic system.
A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with vari... more A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with various types of amines using water as an environment friendly solvent at room temperature has been developed. The significant features of this methodology are short reaction time and easy product separation. This approach provides various biologically active compounds in good to excellent yields without adding any catalyst, ligand, or base.
An intriguing conversion of 3-bromo-2H-coumarins to 3-(benzofuran-2-yl)-2H-coumarins under pallad... more An intriguing conversion of 3-bromo-2H-coumarins to 3-(benzofuran-2-yl)-2H-coumarins under palladium catalysis is reported. The process involves, from only one single starting material, three transformations and two bond formations in one pot: C−C bond formation via C−H activation and C−O bond formation through 2H-coumarin-to-benzofuran ring contraction under palladium catalysis. Moreover, the photophysical properties of all synthesized compounds were studied.
The new bioglycerol-based carbon catalyst acts as an efficient, readily available, and reusable c... more The new bioglycerol-based carbon catalyst acts as an efficient, readily available, and reusable catalyst for the synthesis of amides, when aldehyde and hydroxylamine hydrochloride react in acetonitrile.
A simple, efficient, and eco-friendly synthetic protocol has been developed for the preparation o... more A simple, efficient, and eco-friendly synthetic protocol has been developed for the preparation of diaryl selenium compounds. To the best of our knowledge, this is the first Letter on the use of selenium dioxide as selenium source for the synthesis of diaryl selenides. Compared with other selenium sources the new source SeO 2 gives an environment-friendly and low-cost synthetic route, which may be useful for large-scale synthesis.
We describe here an efficient ruthenium-catalyzed C–H bond ortho-arylation of 9-(pyrimidin-2-yl)-... more We describe here an efficient ruthenium-catalyzed C–H bond ortho-arylation of 9-(pyrimidin-2-yl)-9H-carbazole by using boronic acids. This methodology exhibits excellent and high site-selectivity, functional group tolerance and was found to give the desired product in moderate to good yields.
An efficient Pd-catalyzed decarboxylative coupling of heterocyclic carboxylic acids with heterocy... more An efficient Pd-catalyzed decarboxylative coupling of heterocyclic carboxylic acids with heterocyclic halides to
achieve the synthesis of biheterocycles of biological interest has been reported. In all cases, the cross-coupling reactions take place
rapidly in DMSO in good yields and efficiently proceed in the presence of a PdBr2/DPEphos catalytic system, furnishing the
novel biheterocycles based on quinolin-4-one, quinolin-2-one, chromone, and coumarin scaffolds.
A novel, simple and efficient synthetic protocol has been developed for the synthesis of spiro[in... more A novel, simple and efficient synthetic protocol has been developed for the synthesis of spiro[indoline-
3,40-pyrano[2,3-c]pyrazole]-30-carboxylate and trifluoromethylated spiro[indole-3,40-pyrano[2,3-c]pyrazole]
derivatives via a one pot, four-component reaction using recyclable polyethylene glycol (PEG-400). This new
protocol produces novel spiro pyranopyrazole derivatives in good to excellent yields, with operational
simplicity and recycling of PEG-400. The remarkable features of this methodology are high yields, an easy
work-up process, and a greener method that avoids toxic catalyst and hazardous solvents.
A simple and highly practical method for the direct C–H arylation of benzothiazoles has been deve... more A simple and highly practical method for the direct C–H arylation of benzothiazoles has been developed
by using nano copper ferrite as a recyclable catalyst. The CuFe2O4 nano could be recovered and reused
without significant loss of catalytic activity.
A facile, efficient, and environmentally-friendly one pot protocol has been developed for the synt... more A facile, efficient, and environmentally-friendly one pot protocol has been developed for the synthesis of
1,4-diaryl-1,2,3-triazoles from boronic acids, sodium azide, and acetylenes using copper sulfate
immobilized on chitosan as a recyclable heterogeneous catalyst. This green synthetic three component
protocol avoids handling of hazardous and toxic azides involving its in situ generation. The use of
aqueous medium at room temperature and the easy recovery of the catalyst are other remarkable
features of this procedure.
A novel one pot synthesis of b-hydroxy-1,4-disubstituted-1,2,3-triazoles has been developed by us... more A novel one pot synthesis of b-hydroxy-1,4-disubstituted-1,2,3-triazoles has been developed by using
CuFe2O4 magnetic nanoparticles. This methodology involves additive free, easily recyclable catalyst in
water medium and avoids the handling of organic azides as they are generated in situ
A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been... more A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been
developed by using nano copper ferrite as a magnetically separable, recyclable catalyst. The present
tandem process allows to get access to a wide range of 2-N-substituted benzothiazoles in good to
excellent yields by the reaction of benzothiazole with nitrogen nucleophiles in the presence of Cs2CO3 as a base. The nano CuFe2O4 could be recovered and reused with no significant loss of catalytic activity.
Iodides are generally more efficient than other halides.
Benzyl azides, generate in situ, undergo 1,3-dipolar cycloaddition with alkynes to produce variou... more Benzyl azides, generate in situ, undergo 1,3-dipolar cycloaddition with alkynes to produce various triazole derivatives.
The eco-friendly one-pot method renders possible the synthesis of a broad spectrum of pharmacolog... more The eco-friendly one-pot method renders possible the synthesis of a broad spectrum of pharmacologically important title compounds.
The simple protocol allows the rapid access to biologically important scaffolds such as (IV) and ... more The simple protocol allows the rapid access to biologically important scaffolds such as (IV) and (VII).
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Books by Dr. Harsha Vardhan Reddy Kasireddy
Papers by Dr. Harsha Vardhan Reddy Kasireddy
achieve the synthesis of biheterocycles of biological interest has been reported. In all cases, the cross-coupling reactions take place
rapidly in DMSO in good yields and efficiently proceed in the presence of a PdBr2/DPEphos catalytic system, furnishing the
novel biheterocycles based on quinolin-4-one, quinolin-2-one, chromone, and coumarin scaffolds.
3,40-pyrano[2,3-c]pyrazole]-30-carboxylate and trifluoromethylated spiro[indole-3,40-pyrano[2,3-c]pyrazole]
derivatives via a one pot, four-component reaction using recyclable polyethylene glycol (PEG-400). This new
protocol produces novel spiro pyranopyrazole derivatives in good to excellent yields, with operational
simplicity and recycling of PEG-400. The remarkable features of this methodology are high yields, an easy
work-up process, and a greener method that avoids toxic catalyst and hazardous solvents.
by using nano copper ferrite as a recyclable catalyst. The CuFe2O4 nano could be recovered and reused
without significant loss of catalytic activity.
1,4-diaryl-1,2,3-triazoles from boronic acids, sodium azide, and acetylenes using copper sulfate
immobilized on chitosan as a recyclable heterogeneous catalyst. This green synthetic three component
protocol avoids handling of hazardous and toxic azides involving its in situ generation. The use of
aqueous medium at room temperature and the easy recovery of the catalyst are other remarkable
features of this procedure.
CuFe2O4 magnetic nanoparticles. This methodology involves additive free, easily recyclable catalyst in
water medium and avoids the handling of organic azides as they are generated in situ
developed by using nano copper ferrite as a magnetically separable, recyclable catalyst. The present
tandem process allows to get access to a wide range of 2-N-substituted benzothiazoles in good to
excellent yields by the reaction of benzothiazole with nitrogen nucleophiles in the presence of Cs2CO3 as a base. The nano CuFe2O4 could be recovered and reused with no significant loss of catalytic activity.
achieve the synthesis of biheterocycles of biological interest has been reported. In all cases, the cross-coupling reactions take place
rapidly in DMSO in good yields and efficiently proceed in the presence of a PdBr2/DPEphos catalytic system, furnishing the
novel biheterocycles based on quinolin-4-one, quinolin-2-one, chromone, and coumarin scaffolds.
3,40-pyrano[2,3-c]pyrazole]-30-carboxylate and trifluoromethylated spiro[indole-3,40-pyrano[2,3-c]pyrazole]
derivatives via a one pot, four-component reaction using recyclable polyethylene glycol (PEG-400). This new
protocol produces novel spiro pyranopyrazole derivatives in good to excellent yields, with operational
simplicity and recycling of PEG-400. The remarkable features of this methodology are high yields, an easy
work-up process, and a greener method that avoids toxic catalyst and hazardous solvents.
by using nano copper ferrite as a recyclable catalyst. The CuFe2O4 nano could be recovered and reused
without significant loss of catalytic activity.
1,4-diaryl-1,2,3-triazoles from boronic acids, sodium azide, and acetylenes using copper sulfate
immobilized on chitosan as a recyclable heterogeneous catalyst. This green synthetic three component
protocol avoids handling of hazardous and toxic azides involving its in situ generation. The use of
aqueous medium at room temperature and the easy recovery of the catalyst are other remarkable
features of this procedure.
CuFe2O4 magnetic nanoparticles. This methodology involves additive free, easily recyclable catalyst in
water medium and avoids the handling of organic azides as they are generated in situ
developed by using nano copper ferrite as a magnetically separable, recyclable catalyst. The present
tandem process allows to get access to a wide range of 2-N-substituted benzothiazoles in good to
excellent yields by the reaction of benzothiazole with nitrogen nucleophiles in the presence of Cs2CO3 as a base. The nano CuFe2O4 could be recovered and reused with no significant loss of catalytic activity.