The motivation behind this introduction is to feature the known and deep impact subjected to the ... more The motivation behind this introduction is to feature the known and deep impact subjected to the Nipah Virus (NiV). Principally concentrating on preventive measures and the treatment of the Nipah Virus. NiV is an individual from the family Paramyxoviridae, class Henipavirus. NiV was at first recognized in 1999, amid a flare-up of Encephalitis and respiratory sickness among pig ranchers and individuals with close contact with pigs in Malaysia and Singapore. Nipah infection caused a generally gentle ailment in pigs, yet almost 300 human cases with more than 100 passings were accounted for in 1999. Not just in Malaysia its spread around the world. A case-controlled survey ponder is directed to decide word related hazard factors for disease. Contact with live pigs, earmarks of being the essential hazard factor for human Nipah infection disease. Coordinate contact with life, possibly contaminated pigs ought to be limited to forestall transmission of this conceivably lethal ZOONOSIS to pe...
Molecular docking studies were performed on 100 newly designed isatin analogs using Glide v 5.0 o... more Molecular docking studies were performed on 100 newly designed isatin analogs using Glide v 5.0 on the active site of four different enzymes namely human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) protein data bank (PDB ID 1RT2), glucosamine 6-phosphate (GlcN6P) (PDB ID 2VF5), Mycobacterium tuberculosis-CYP51 (PDB code 1EA1) and Candida albicans (CACYP51) (PDB code chimeric-1EA1) to study the binding mode of these analogs to study the binding mode of these analogs. Binding mode analysis of the compounds with the highest docking scores (−11.67, −7.31, −7.12 and −8.54) were carried out and compared with that of the co crystallized ligands TNK651, glucosamine (glucagon-like peptide) and fluconazole (TPF) in the active sites of 1RT2, 2VF5,1EA1, and chimeric 1EA1 respectively. Absorption, distribution, metabolism and excretion (ADME) properties of all the newly designed isatin analogs 1-100 was calculated by QikProp v 3.0. All the designed compounds were found to exhibit l...
The motivation behind this introduction is to feature the known and deep impact subjected to the ... more The motivation behind this introduction is to feature the known and deep impact subjected to the Nipah Virus (NiV). Principally concentrating on preventive measures and the treatment of the Nipah Virus. NiV is an individual from the family Paramyxoviridae, class Henipavirus. NiV was at first recognized in 1999, amid a flare-up of Encephalitis and respiratory sickness among pig ranchers and individuals with close contact with pigs in Malaysia and Singapore. Nipah infection caused a generally gentle ailment in pigs, yet almost 300 human cases with more than 100 passings were accounted for in 1999. Not just in Malaysia its spread around the world. A case-controlled survey ponder is directed to decide word related hazard factors for disease. Contact with live pigs, earmarks of being the essential hazard factor for human Nipah infection disease. Coordinate contact with life, possibly contaminated pigs ought to be limited to forestall transmission of this conceivably lethal ZOONOSIS to pe...
The motivation behind this introduction is to feature the known and deep impact subjected to the ... more The motivation behind this introduction is to feature the known and deep impact subjected to the Nipah Virus (NiV). Principally concentrating on preventive measures and the treatment of the Nipah Virus. NiV is an individual from the family Paramyxoviridae, class Henipavirus. NiV was at first recognized in 1999, amid a flare-up of Encephalitis and respiratory sickness among pig ranchers and individuals with close contact with pigs in Malaysia and Singapore. Nipah infection caused a generally gentle ailment in pigs, yet almost 300 human cases with more than 100 passings were accounted for in 1999. Not just in Malaysia its spread around the world. A case-controlled survey ponder is directed to decide word related hazard factors for disease. Contact with live pigs, earmarks of being the essential hazard factor for human Nipah infection disease. Coordinate contact with life, possibly contaminated pigs ought to be limited to forestall transmission of this conceivably lethal ZOONOSIS to pe...
Molecular docking studies were performed on 100 newly designed isatin analogs using Glide v 5.0 o... more Molecular docking studies were performed on 100 newly designed isatin analogs using Glide v 5.0 on the active site of four different enzymes namely human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) protein data bank (PDB ID 1RT2), glucosamine 6-phosphate (GlcN6P) (PDB ID 2VF5), Mycobacterium tuberculosis-CYP51 (PDB code 1EA1) and Candida albicans (CACYP51) (PDB code chimeric-1EA1) to study the binding mode of these analogs to study the binding mode of these analogs. Binding mode analysis of the compounds with the highest docking scores (−11.67, −7.31, −7.12 and −8.54) were carried out and compared with that of the co crystallized ligands TNK651, glucosamine (glucagon-like peptide) and fluconazole (TPF) in the active sites of 1RT2, 2VF5,1EA1, and chimeric 1EA1 respectively. Absorption, distribution, metabolism and excretion (ADME) properties of all the newly designed isatin analogs 1-100 was calculated by QikProp v 3.0. All the designed compounds were found to exhibit l...
The motivation behind this introduction is to feature the known and deep impact subjected to the ... more The motivation behind this introduction is to feature the known and deep impact subjected to the Nipah Virus (NiV). Principally concentrating on preventive measures and the treatment of the Nipah Virus. NiV is an individual from the family Paramyxoviridae, class Henipavirus. NiV was at first recognized in 1999, amid a flare-up of Encephalitis and respiratory sickness among pig ranchers and individuals with close contact with pigs in Malaysia and Singapore. Nipah infection caused a generally gentle ailment in pigs, yet almost 300 human cases with more than 100 passings were accounted for in 1999. Not just in Malaysia its spread around the world. A case-controlled survey ponder is directed to decide word related hazard factors for disease. Contact with live pigs, earmarks of being the essential hazard factor for human Nipah infection disease. Coordinate contact with life, possibly contaminated pigs ought to be limited to forestall transmission of this conceivably lethal ZOONOSIS to pe...
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