Papers by Muhammad Al Shorbagy
PlosOne, Oct 3, 2013
Several studies have addressed the antiepileptic mechanisms of levetiracetam (LEV); however, its ... more Several studies have addressed the antiepileptic mechanisms of levetiracetam (LEV); however, its effect on catecholamines and the inflammatory mediators that play a role in epilepsy remain elusive. In the current work, lithium (Li) pretreated animals were administered LEV (500 mg/kg i.p) 30 min before the induction of convulsions by pilocarpine (PIL). Li-PIL-induced seizures were accompanied by increased levels of hippocampal prostaglandin (PG) E2, myeloperoxidase (MPO), tumor necrosis factor-α, and interleukin-10. Moreover, it markedly elevated hippocampal lipid peroxides and nitric oxide levels, while it inhibited the glutathione content. Li-PIL also reduced hippocampal noradrenaline, as well as dopamine contents. Pretreatment with LEV protected against Li-PIL-induced seizures, where it suppressed the severity and delayed the onset of seizures in Li-PIL treated rats. Moreover, LEV reduced PGE2 and MPO, yet it did not affect the level of both cytokines in the hippocampus. LEV also normalized hippocampal noradrenaline, dopamine, glutathione, lipid peroxides, and nitric oxide contents. In conclusion, alongside its antioxidant property, LEV anticonvulsive effect involves catecholamines restoration, as well as inhibition of PGE2, MPO, and nitric oxide.
Canadian journal of …, 2011
Corticosteroids are used in the management of several epileptic aliments; however, their effectiv... more Corticosteroids are used in the management of several epileptic aliments; however, their effectiveness in combating seizures remains controversial, with pro- and anti-convulsive effects ascribed. The current study aimed to address the modulatory effect of dexamethasone (DEX) utilizing 3 dose levels (5, 10, and 20 mg/kg body mass of male Wistar rat) in the rat lithium-pilocarpine (Li-PIL) epilepsy model. Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E(2), tumor necrosis factor (TNF)-α, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus. However, Li-PIL compromised the oxidant-antioxidant balance of the hippocampus. Effective anticonvulsant activity was only observed with 10 mg DEX/kg body mass, which reduced seizure production and incidence, as well as neuronal cell loss in the CA3 region. At this anticonvulsant dose, enhancements in the antioxidant system and IL-10, as well as suppression of altered inflammatory markers were observed. Conversely, doubling the dose showed a tendency to shorten seizure latency, and neither affected seizure incidence nor CA3 neuronal cell loss. These effects were associated with an increase in levels of PGE(2) and TNF-α. The present study found a lack of protection at 5 mg DEX/kg body mass, an anticonvulsant effect at 10 mg/kg, and a loss of protection at 20 mg/kg in the Li-PIL epilepsy model, which indicates that there is an optimal dose of DEX for preventing the induction of seizures.
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ABSTRACT The micronutrient β-carotene possesses myriad effects attributed mainly to its antioxida... more ABSTRACT The micronutrient β-carotene possesses myriad effects attributed mainly to its antioxidant potential and was reported to play a key role in protecting against several disorders linked to oxidative stress, including peptic ulcer disease. The present investigation was performed to evaluate possible mechanism(s) involved in its reported antiulcerogenic activity. Indomethacin (20 mg/kg, i.p) produced gastric mucosal lesions in male Wistar rats, where its ulcerogenic effect was accompanied by increased titratable acidity, decreased gastric juice volume and mucin concentration. This NSAID disturbed redox state of the gastric mucosa and increased neutrophil infiltration. -Carotene (10 mg/kg, p.o) exerted an obvious antiulcer effect that was shown by the reduction in the ulcer index and restoration of the gastric mucosal redox state. However, this micronutrient neither affected the secretion of gastric acid and mucin nor the volume of the gastric juice. -Tocopherol (400 IU/kg, p....
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Papers by Muhammad Al Shorbagy
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