Asiatic pennywort or Centella asiatica (L.) Urban is a Herbal medicine, which is used for medicin... more Asiatic pennywort or Centella asiatica (L.) Urban is a Herbal medicine, which is used for medicines, cosmetics, food supplement and health products. The pharmacological activities of pennywort are for wound healing, keloid treatment and antimicrobial activity. Transdermal drug patch for pennywort developed to reduce frequency for product usage per day. This helps for the pharmacy administration. The developed transdermal delivery system, was comprised of backing layer and adhesive layer which loaded herbal extraction. Different polymers such as ethyl cellulose (EC), eudragit E 100, eudragit NE 30 D, hydroxypropyl methyl cellulose with various concentrations (1.0%, 2.0% and 3.0% w/v) for backing layer and adhesive layer were studied. In addition, two plasticizers triacetin and dibutyl Phathalate (DBP) were also studied for the transdermal delivery system. The result demonstrated that 2.0% EC and 30% triacetin was suitable for backing layer in transdermal patch because transdermal pat...
Oral acute toxcity of Centella asiatica (L.) Urban powder (CA) in mice revealed that median letha... more Oral acute toxcity of Centella asiatica (L.) Urban powder (CA) in mice revealed that median lethal dose (LD50) of CA was more than 8 g/kg body weight. Histopathological study revealed no abnormality contributed to CA. Chronic toxicity has been investigated in six groups of Wistar rats, each of 30 rats (15 of each sex). Group 1 was the water control group while group 2 to 5 received CA by oral administration at the doses of 20, 200, 600 and 1200 mg/kg/day respectively for six months. Group 6, a recovery group, received 2000 mg/kg CA and the administration was withdrawn two weeks before sacrificed. The result revealed that average body weight and food consumption in all CA-treated groups were not different from those of the control groups. Male rats receiving CA at 600 and 1200 mg/kg had significantly less white blood cell counts than the control group (p<0.05); however the number of white blood cell increased after CA discontinuation for 2 weeks. Male rats receiving 600 mg/kg CA a...
Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatu... more Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.). Among these plants, the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae. To gain more information on larvicidal activity of P. retrofractum, fresh fruits of this plant were extracted in water and the extracts made into powder and bioassayed against 3rd and 4th instar larvae of Cx. quinquefasciatus and Ae. aegypti in the laboratory. Extracts of unripe (001/3) and ripe (002/3 and 001/4) fruits showed different levels of activity against Cx. quinquefasciatus larvae. Extracts 001/3 and 002/3 were equi-toxic to a Bacillus sphaericus resistant and susceptible strains, both from Thailand. The ripe fruit extract 002/3 was somewhat more active against Ae. aegypti than Cx. quinquefasciatus. Another ripe fruit extract (001/4) was much more toxic to both mosquito species. Diluted solutions of the solid extra...
Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1... more Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1.0%. by weight. The 5 cream bases were anionic and nonionic from British Pharmacopoeia (B.P) and National Formulary of Essential Drug of Thailand (E.D.) i.e. cetomacrogol cream B.P.(F1), nonionic buttered cream (E.D.) (F2), anionic simple cream B.P. (F3), anionic buffered cream B.P. (F4), and the formulated nonionic cream base (F5). The creams were examined for antimicrobial activity against Staphylococcus aureus (S.aureus), Candida albians (C. albians ) and Propionibacterium acnes (P.ances) by agar diffusion method. The results showed that among the creams composed of 0.2% turmeric extract, only F3 could inhibit P.ances . The F2, F3, F4 and F5 containing 1.0% turmeric extract could inhibit S.aureus : The F5 containing 1% turmeric extract affected C. albians whereas F3 and F4 could inhibit P.ances . From the stability accelerated test, all creams containing 1.0% turmeric extract showed g...
Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatu... more Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.). Among these plants, the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae. To gain more information on larvicidal activity of P. retrofractum, fresh fruits of this plant were extracted in water and the extracts made into powder and bioassayed against 3 rd and 4 th instar larvae of Cx. quinquefasciatus and Ae. aegypti in the laboratory. Extracts of unripe (001/3) and ripe (002/3 and 001/4) fruits showed different levels of activity against Cx. quinquefasciatus larvae. Extracts 001/3 and 002/3 were equi-toxic to a Bacillus sphaericus resistant and susceptible strains, both from Thailand. The ripe fruit extract 002/3 was somewhat more active against Ae. aegypti than Cx. quinquefasciatus. Another ripe fruit extract (001/4) was much more toxic to both mosquito species. Diluted solutions of the solid ext...
Region 4 5 Medical Journal วารสารแพทย์เขต ๔ ๕, Oct 13, 2011
Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1... more Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1.0%. by weight. The 5 cream bases were anionic and nonionic from British Pharmacopoeia (B.P) and National Formulary of Essential Drug of Thailand (E.D.) i.e. cetomacrogol cream B.P.(F1), nonionic buttered cream (E.D.) (F2), anionic simple cream B.P. (F3), anionic buffered cream B.P. (F4), and the formulated nonionic cream base (F5). The creams were examined for antimicrobial activity against Staphylococcus aureus (S.aureus), Candida albians (C. albians ) and Propionibacterium acnes (P.ances) by agar diffusion method. The results showed that among the creams composed of 0.2% turmeric extract, only F3 could inhibit P.ances . The F2, F3, F4 and F5 containing 1.0% turmeric extract could inhibit S.aureus : The F5 containing 1% turmeric extract affected C. albians whereas F3 and F4 could inhibit P.ances . From the stability accelerated test, all creams containing 1.0% turmeric extract showed good physical stability. Keywords: ขมนชน, ครมพน, ฤทธตานเชอจลนทรย, Curcuma longa, turmeric, cream base, antimicrobial activity
Asiatic pennywort or Centella asiatica (L.) Urban is a Herbal medicine, which is used for medicin... more Asiatic pennywort or Centella asiatica (L.) Urban is a Herbal medicine, which is used for medicines, cosmetics, food supplement and health products. The pharmacological activities of pennywort are for wound healing, keloid treatment and antimicrobial activity. Transdermal drug patch for pennywort developed to reduce frequency for product usage per day. This helps for the pharmacy administration. The developed transdermal delivery system, was comprised of backing layer and adhesive layer which loaded herbal extraction. Different polymers such as ethyl cellulose (EC), eudragit E 100, eudragit NE 30 D, hydroxypropyl methyl cellulose with various concentrations (1.0%, 2.0% and 3.0% w/v) for backing layer and adhesive layer were studied. In addition, two plasticizers triacetin and dibutyl Phathalate (DBP) were also studied for the transdermal delivery system. The result demonstrated that 2.0% EC and 30% triacetin was suitable for backing layer in transdermal patch because transdermal pat...
Oral acute toxcity of Centella asiatica (L.) Urban powder (CA) in mice revealed that median letha... more Oral acute toxcity of Centella asiatica (L.) Urban powder (CA) in mice revealed that median lethal dose (LD50) of CA was more than 8 g/kg body weight. Histopathological study revealed no abnormality contributed to CA. Chronic toxicity has been investigated in six groups of Wistar rats, each of 30 rats (15 of each sex). Group 1 was the water control group while group 2 to 5 received CA by oral administration at the doses of 20, 200, 600 and 1200 mg/kg/day respectively for six months. Group 6, a recovery group, received 2000 mg/kg CA and the administration was withdrawn two weeks before sacrificed. The result revealed that average body weight and food consumption in all CA-treated groups were not different from those of the control groups. Male rats receiving CA at 600 and 1200 mg/kg had significantly less white blood cell counts than the control group (p<0.05); however the number of white blood cell increased after CA discontinuation for 2 weeks. Male rats receiving 600 mg/kg CA a...
Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatu... more Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.). Among these plants, the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae. To gain more information on larvicidal activity of P. retrofractum, fresh fruits of this plant were extracted in water and the extracts made into powder and bioassayed against 3rd and 4th instar larvae of Cx. quinquefasciatus and Ae. aegypti in the laboratory. Extracts of unripe (001/3) and ripe (002/3 and 001/4) fruits showed different levels of activity against Cx. quinquefasciatus larvae. Extracts 001/3 and 002/3 were equi-toxic to a Bacillus sphaericus resistant and susceptible strains, both from Thailand. The ripe fruit extract 002/3 was somewhat more active against Ae. aegypti than Cx. quinquefasciatus. Another ripe fruit extract (001/4) was much more toxic to both mosquito species. Diluted solutions of the solid extra...
Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1... more Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1.0%. by weight. The 5 cream bases were anionic and nonionic from British Pharmacopoeia (B.P) and National Formulary of Essential Drug of Thailand (E.D.) i.e. cetomacrogol cream B.P.(F1), nonionic buttered cream (E.D.) (F2), anionic simple cream B.P. (F3), anionic buffered cream B.P. (F4), and the formulated nonionic cream base (F5). The creams were examined for antimicrobial activity against Staphylococcus aureus (S.aureus), Candida albians (C. albians ) and Propionibacterium acnes (P.ances) by agar diffusion method. The results showed that among the creams composed of 0.2% turmeric extract, only F3 could inhibit P.ances . The F2, F3, F4 and F5 containing 1.0% turmeric extract could inhibit S.aureus : The F5 containing 1% turmeric extract affected C. albians whereas F3 and F4 could inhibit P.ances . From the stability accelerated test, all creams containing 1.0% turmeric extract showed g...
Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatu... more Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.). Among these plants, the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae. To gain more information on larvicidal activity of P. retrofractum, fresh fruits of this plant were extracted in water and the extracts made into powder and bioassayed against 3 rd and 4 th instar larvae of Cx. quinquefasciatus and Ae. aegypti in the laboratory. Extracts of unripe (001/3) and ripe (002/3 and 001/4) fruits showed different levels of activity against Cx. quinquefasciatus larvae. Extracts 001/3 and 002/3 were equi-toxic to a Bacillus sphaericus resistant and susceptible strains, both from Thailand. The ripe fruit extract 002/3 was somewhat more active against Ae. aegypti than Cx. quinquefasciatus. Another ripe fruit extract (001/4) was much more toxic to both mosquito species. Diluted solutions of the solid ext...
Region 4 5 Medical Journal วารสารแพทย์เขต ๔ ๕, Oct 13, 2011
Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1... more Ethanolic extract of Turmeric was incorporated in 5 cream bases at 2 concentrations of 0.2% and 1.0%. by weight. The 5 cream bases were anionic and nonionic from British Pharmacopoeia (B.P) and National Formulary of Essential Drug of Thailand (E.D.) i.e. cetomacrogol cream B.P.(F1), nonionic buttered cream (E.D.) (F2), anionic simple cream B.P. (F3), anionic buffered cream B.P. (F4), and the formulated nonionic cream base (F5). The creams were examined for antimicrobial activity against Staphylococcus aureus (S.aureus), Candida albians (C. albians ) and Propionibacterium acnes (P.ances) by agar diffusion method. The results showed that among the creams composed of 0.2% turmeric extract, only F3 could inhibit P.ances . The F2, F3, F4 and F5 containing 1.0% turmeric extract could inhibit S.aureus : The F5 containing 1% turmeric extract affected C. albians whereas F3 and F4 could inhibit P.ances . From the stability accelerated test, all creams containing 1.0% turmeric extract showed good physical stability. Keywords: ขมนชน, ครมพน, ฤทธตานเชอจลนทรย, Curcuma longa, turmeric, cream base, antimicrobial activity
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