Azaspiracid poisoning (AZP) is a new human toxic syndrome that is caused by the consumption of sh... more Azaspiracid poisoning (AZP) is a new human toxic syndrome that is caused by the consumption of shellfish that have been feeding on harmful marine microalgae. A liquid chromatography–mass spectrometry (LC–MS) method has been developed for the determination of the three most prevalent toxins, azaspiracid (AZA1), 8-methylazaspiracid (AZA2) and 22-demethylazaspiracid (AZA3) as well as the isomeric hydroxylated analogues, AZA4 and AZA5.
In this edition of Pharmaceutical Methods, I am impressed by the number of articles that use as t... more In this edition of Pharmaceutical Methods, I am impressed by the number of articles that use as their means of analysis Liquid Chromatography with UV/Diode Array Detection (DAD). Five or more years ago, the predictions were that all such UV/DAD would be by now replaced by Liquid Chromatography-Mass Spectrometry (LC-MS) technologies.
I am delighted to bring you the good news that our journal Pharmacognosy Research is now indexed ... more I am delighted to bring you the good news that our journal Pharmacognosy Research is now indexed on PubMed Central (PMC) and on the PubMed list. This is a wonderful achievement and a tribute to the hard work and dedication of all our editorial board members most especially the trojan work of our Managing Editor Prof. Muneen Ahmed KK.
Particulate matter ten microns (PM10) is the subject of international publicity, particularly wit... more Particulate matter ten microns (PM10) is the subject of international publicity, particularly with reference to its associated health impacts. The World Health Organisation (WHO) defines PM as “a complex mixture of organic and inorganic substances which, due to its complexity and the importance of particle size, has been defined in different terms; those relating to sampling and analysis, in relation to impact upon the respiratory system and with regard to physiological properties”.
Amnesic shellfish poisoning is a potentially lethal human toxic syndrome which is caused by domoi... more Amnesic shellfish poisoning is a potentially lethal human toxic syndrome which is caused by domoic acid (DA) that originates in marine phytoplankton belonging to the Pseudonitzschia genus. A new sensitive liquid chromatographic–mass spectrometry (LC–MS) method has been developed for the determination of DA in various marine biological samples.
Abstract The medicinal properties of hawthorn (Crataegus spp., a genus comprising approximately 3... more Abstract The medicinal properties of hawthorn (Crataegus spp., a genus comprising approximately 300 species) have been utilized by many cultures for a variety of therapeutic purposes for many centuries. In the Western world cardiovascular disease (CVD) has become one of the single most significant causes of premature death. Echoing this situation, more recent research into the therapeutic benefits of hawthorn preparations has focused primarily upon its cardiovascular effects.
In this month's issue of Pharmacognosy Research, I would like to concentrate on the methodologies... more In this month's issue of Pharmacognosy Research, I would like to concentrate on the methodologies that are employed to assess the nature of the bioactivities of plant extracts. In vivo and/or in vitro test models, together with the structural determination of the chief components, are of course the gold standard in determining the active constituents.
Azaspiracid is the main toxin responsible for a number of recent human intoxications in Europe re... more Azaspiracid is the main toxin responsible for a number of recent human intoxications in Europe resulting from shellfish consumption. The first micro liquid chromatography–tandem mass spectrometry (micro-LC–MS–MS) method was developed for the determination of this novel shellfish poisoning toxin in mussels.
Onasanwo et al. present a very interesting study on the antiulcerogenic and antioxidant activitie... more Onasanwo et al. present a very interesting study on the antiulcerogenic and antioxidant activities of a plant native to tropical Africa called Lagenaria breviflora. The authors investigate the effect of plant extracts in rats that have been exposed to a number of typical peptic ulcer inducing agents including aspirin, pyloric ligation and alcohol.
As researchers we are well aware that plants provide an abundance of compounds, many of which hav... more As researchers we are well aware that plants provide an abundance of compounds, many of which have been shown to be effective in the treatment of ailments for hundreds of years. In the recent past, much work has been undertaken to investigate active compounds in plants traditionally used in herbal medicine, venoms and toxins of animal origin and micro organisms. Researchers have developed in vivo and in vitro models to study bioactivity and have used instrumental means to determine their structure and metabolites.
A surface plasmon resonance (SPR) biosensor screening assay was developed and validated to detect... more A surface plasmon resonance (SPR) biosensor screening assay was developed and validated to detect 11 benzimidazole carbamate (BZT) veterinary drug residues in milk. The polyclonal antibody used was raised in sheep against a methyl 5 (6)-[(carboxypentyl)-thio]-2-benzimidazole carbamate protein conjugate. A sample preparation procedure was developed using a modified QuEChERS method. BZT residues were extracted from milk using liquid extraction/partition with a dispersive solid phase extraction clean-up step.
Anatoxin-a is a naturally occurring neurotoxic alkaloid, produced by several strains of cyanobact... more Anatoxin-a is a naturally occurring neurotoxic alkaloid, produced by several strains of cyanobacteria. Originally, the species, Anabaena flos aquae, was the source of the toxin, which was consequently named anatoxin-a. Since its isolation (Devlin et al. 1977) and characterisation as a (1R, 6R)-2-acetyl-9-azabicyclo [4.2. 1] nonane (Huber et al. 1972; Koskinen and Rapoport 1985) in the 1970s, anatoxin-a (1; Fig. 7.1 A) has stimulated the scientific community worldwide.
Azaspiracids are a family of lipophilic polyether marine biotoxins that have caused a number of h... more Azaspiracids are a family of lipophilic polyether marine biotoxins that have caused a number of human intoxication incidents in Europe since 1995 following the consumption by consumers of intoxicated shellfish (Mytilus edulis). These azaspiracids have now been identified in mussels (Mytilus chilensis) and scallops (Argopecten purpuratus) from two Chilean locations. This is the first report of the occurrence of azaspiracid toxins in these species (Mytilus chilensis and Argopecten purpuratus) from Chile.
Liver fluke, roundworm and lungworm are parasites that can cause disease in food producing animal... more Liver fluke, roundworm and lungworm are parasites that can cause disease in food producing animals (Knubben-Schweizer et al., 2010). Anthelmintic drugs are widely used in veterinary medicine for protection or treatment of animals against parasitic disease. Nitroxynil is active against mature and immature liver fluke.
A total of 220 lactic acid bacteria isolates were screened for antifungal activity using Aspergil... more A total of 220 lactic acid bacteria isolates were screened for antifungal activity using Aspergillus fumigatus and Aspergillus niger as the target strains. Four Lactobacillus strains exhibited strong inhibitory activity on agar surfaces. All four were also identified as having strong inhibitory activity against the human pathogenic fungi Microsporum canis, Microsporum gypseum and Epidermophyton floccosum. One of the four lactobacilli, namely Lb. reuteri ee1p exhibited the most inhibition against dermatophytes.
Abstract Polyether marine toxins belonging to the diarrhetic shellfish poisoning (DSP) class were... more Abstract Polyether marine toxins belonging to the diarrhetic shellfish poisoning (DSP) class were detected by LC-MS operating in the positive ion mode. LC-MSn experiments resulted in fragmentation patterns for each toxin found in phytoplankton samples, and was supplemented with data from high-resolution mass spectra obtained using a QqTOF mass spectrometer. The combination of this instrumentation permits toxinology studies on very small samples, including picked phytoplankton cells that cannot be cultured.
In November, 1995, at least eight people in the Netherlands became ill after eating mussels (Myti... more In November, 1995, at least eight people in the Netherlands became ill after eating mussels (Mytilus edulis) cultivated at Killary Harbor, Ireland. Although human symptoms such as nausea, vomiting, severe diarrhea, and stomach cramps were reminiscent of diarrhetic ...
Azaspiracid poisoning (AZP) is a new human toxic syndrome that is caused by the consumption of sh... more Azaspiracid poisoning (AZP) is a new human toxic syndrome that is caused by the consumption of shellfish that have been feeding on harmful marine microalgae. A liquid chromatography–mass spectrometry (LC–MS) method has been developed for the determination of the three most prevalent toxins, azaspiracid (AZA1), 8-methylazaspiracid (AZA2) and 22-demethylazaspiracid (AZA3) as well as the isomeric hydroxylated analogues, AZA4 and AZA5.
In this edition of Pharmaceutical Methods, I am impressed by the number of articles that use as t... more In this edition of Pharmaceutical Methods, I am impressed by the number of articles that use as their means of analysis Liquid Chromatography with UV/Diode Array Detection (DAD). Five or more years ago, the predictions were that all such UV/DAD would be by now replaced by Liquid Chromatography-Mass Spectrometry (LC-MS) technologies.
I am delighted to bring you the good news that our journal Pharmacognosy Research is now indexed ... more I am delighted to bring you the good news that our journal Pharmacognosy Research is now indexed on PubMed Central (PMC) and on the PubMed list. This is a wonderful achievement and a tribute to the hard work and dedication of all our editorial board members most especially the trojan work of our Managing Editor Prof. Muneen Ahmed KK.
Particulate matter ten microns (PM10) is the subject of international publicity, particularly wit... more Particulate matter ten microns (PM10) is the subject of international publicity, particularly with reference to its associated health impacts. The World Health Organisation (WHO) defines PM as “a complex mixture of organic and inorganic substances which, due to its complexity and the importance of particle size, has been defined in different terms; those relating to sampling and analysis, in relation to impact upon the respiratory system and with regard to physiological properties”.
Amnesic shellfish poisoning is a potentially lethal human toxic syndrome which is caused by domoi... more Amnesic shellfish poisoning is a potentially lethal human toxic syndrome which is caused by domoic acid (DA) that originates in marine phytoplankton belonging to the Pseudonitzschia genus. A new sensitive liquid chromatographic–mass spectrometry (LC–MS) method has been developed for the determination of DA in various marine biological samples.
Abstract The medicinal properties of hawthorn (Crataegus spp., a genus comprising approximately 3... more Abstract The medicinal properties of hawthorn (Crataegus spp., a genus comprising approximately 300 species) have been utilized by many cultures for a variety of therapeutic purposes for many centuries. In the Western world cardiovascular disease (CVD) has become one of the single most significant causes of premature death. Echoing this situation, more recent research into the therapeutic benefits of hawthorn preparations has focused primarily upon its cardiovascular effects.
In this month's issue of Pharmacognosy Research, I would like to concentrate on the methodologies... more In this month's issue of Pharmacognosy Research, I would like to concentrate on the methodologies that are employed to assess the nature of the bioactivities of plant extracts. In vivo and/or in vitro test models, together with the structural determination of the chief components, are of course the gold standard in determining the active constituents.
Azaspiracid is the main toxin responsible for a number of recent human intoxications in Europe re... more Azaspiracid is the main toxin responsible for a number of recent human intoxications in Europe resulting from shellfish consumption. The first micro liquid chromatography–tandem mass spectrometry (micro-LC–MS–MS) method was developed for the determination of this novel shellfish poisoning toxin in mussels.
Onasanwo et al. present a very interesting study on the antiulcerogenic and antioxidant activitie... more Onasanwo et al. present a very interesting study on the antiulcerogenic and antioxidant activities of a plant native to tropical Africa called Lagenaria breviflora. The authors investigate the effect of plant extracts in rats that have been exposed to a number of typical peptic ulcer inducing agents including aspirin, pyloric ligation and alcohol.
As researchers we are well aware that plants provide an abundance of compounds, many of which hav... more As researchers we are well aware that plants provide an abundance of compounds, many of which have been shown to be effective in the treatment of ailments for hundreds of years. In the recent past, much work has been undertaken to investigate active compounds in plants traditionally used in herbal medicine, venoms and toxins of animal origin and micro organisms. Researchers have developed in vivo and in vitro models to study bioactivity and have used instrumental means to determine their structure and metabolites.
A surface plasmon resonance (SPR) biosensor screening assay was developed and validated to detect... more A surface plasmon resonance (SPR) biosensor screening assay was developed and validated to detect 11 benzimidazole carbamate (BZT) veterinary drug residues in milk. The polyclonal antibody used was raised in sheep against a methyl 5 (6)-[(carboxypentyl)-thio]-2-benzimidazole carbamate protein conjugate. A sample preparation procedure was developed using a modified QuEChERS method. BZT residues were extracted from milk using liquid extraction/partition with a dispersive solid phase extraction clean-up step.
Anatoxin-a is a naturally occurring neurotoxic alkaloid, produced by several strains of cyanobact... more Anatoxin-a is a naturally occurring neurotoxic alkaloid, produced by several strains of cyanobacteria. Originally, the species, Anabaena flos aquae, was the source of the toxin, which was consequently named anatoxin-a. Since its isolation (Devlin et al. 1977) and characterisation as a (1R, 6R)-2-acetyl-9-azabicyclo [4.2. 1] nonane (Huber et al. 1972; Koskinen and Rapoport 1985) in the 1970s, anatoxin-a (1; Fig. 7.1 A) has stimulated the scientific community worldwide.
Azaspiracids are a family of lipophilic polyether marine biotoxins that have caused a number of h... more Azaspiracids are a family of lipophilic polyether marine biotoxins that have caused a number of human intoxication incidents in Europe since 1995 following the consumption by consumers of intoxicated shellfish (Mytilus edulis). These azaspiracids have now been identified in mussels (Mytilus chilensis) and scallops (Argopecten purpuratus) from two Chilean locations. This is the first report of the occurrence of azaspiracid toxins in these species (Mytilus chilensis and Argopecten purpuratus) from Chile.
Liver fluke, roundworm and lungworm are parasites that can cause disease in food producing animal... more Liver fluke, roundworm and lungworm are parasites that can cause disease in food producing animals (Knubben-Schweizer et al., 2010). Anthelmintic drugs are widely used in veterinary medicine for protection or treatment of animals against parasitic disease. Nitroxynil is active against mature and immature liver fluke.
A total of 220 lactic acid bacteria isolates were screened for antifungal activity using Aspergil... more A total of 220 lactic acid bacteria isolates were screened for antifungal activity using Aspergillus fumigatus and Aspergillus niger as the target strains. Four Lactobacillus strains exhibited strong inhibitory activity on agar surfaces. All four were also identified as having strong inhibitory activity against the human pathogenic fungi Microsporum canis, Microsporum gypseum and Epidermophyton floccosum. One of the four lactobacilli, namely Lb. reuteri ee1p exhibited the most inhibition against dermatophytes.
Abstract Polyether marine toxins belonging to the diarrhetic shellfish poisoning (DSP) class were... more Abstract Polyether marine toxins belonging to the diarrhetic shellfish poisoning (DSP) class were detected by LC-MS operating in the positive ion mode. LC-MSn experiments resulted in fragmentation patterns for each toxin found in phytoplankton samples, and was supplemented with data from high-resolution mass spectra obtained using a QqTOF mass spectrometer. The combination of this instrumentation permits toxinology studies on very small samples, including picked phytoplankton cells that cannot be cultured.
In November, 1995, at least eight people in the Netherlands became ill after eating mussels (Myti... more In November, 1995, at least eight people in the Netherlands became ill after eating mussels (Mytilus edulis) cultivated at Killary Harbor, Ireland. Although human symptoms such as nausea, vomiting, severe diarrhea, and stomach cramps were reminiscent of diarrhetic ...
Uploads
Papers by Ambrose Furey