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Authors: Verde, Federico | Aiello, Edoardo Nicolò | Adobbati, Laura | Poletti, Barbara | Solca, Federica | Tiloca, Cinzia | Sangalli, Davide | Maranzano, Alessio | Muscio, Cristina | Ratti, Antonia | Zago, Stefano | Ticozzi, Nicola | Frisoni, Giovanni Battista | Silani, Vincenzo

Article Type: Short Communication

Abstract: We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer’s disease (AD) and review the literature about the coexistence of the two entities, highlighting the following: mean age at onset is 63.8 years, with slight female predominance; ALS tends to manifest after cognitive impairment and often begins in the bulbar region; average disease duration is 3 years; cognitive phenotype is mostly amnestic; the pattern of brain involvement is, in most cases, consistent with AD. Our case and the reviewed ones suggest that patients with ALS and dementia lacking unequivocal features of FTD should undergo additional examinations in order …to recognize AD. Show more

Keywords: Alzheimer’s disease, amyotrophic lateral sclerosis, neurodegeneration, neuropsychology

DOI: 10.3233/JAD-230562

Citation: Journal of Alzheimer's Disease, vol. 95, no. 4, pp. 1383-1399, 2023