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Your search for: 'author:("Benedek, George B.")' has returned 1 result. (0.013s)

The ELISA-Measured Increase in Cerebrospinal Fluid Tau that Discriminates Alzheimer's Disease from other Neurodegenerative Disorders is not Attributable to Differential Recognition of Tau Assembly For…

Authors: O'Dowd, Seán T. | Ardah, Mustafa T. | Johansson, Per | Lomakin, Aleksey | Benedek, George B. | Roberts, Kinley A. | Cummins, Gemma | El Agnaf, Omar M. | Svensson, Johan | Zetterberg, Henrik | Lynch, Timothy | Walsh, Dominic M.

Article Type: Short Communication

Abstract: Elevated cerebrospinal fluid concentrations of tau discriminate Alzheimer's disease from other neurodegenerative conditions. The reasons for this are unclear. While commercial assay kits are widely used to determine total-tau concentrations, little is known about their ability to detect different aggregation states of tau. We demonstrate that the leading commercial enzyme-linked immunosorbent assay reliably detects aggregated and monomeric tau and evinces good recovery of both species when added into cerebrospinal fluid. Hence, the disparity between total-tau levels encountered in Alzheimer's disease and other neurodegenerative conditions is not due to differential recognition of tau assembly forms or the extent of degeneration.

Keywords: Alzheimer's disease, cerebrospinal fluid, ELISA, tau

DOI: 10.3233/JAD-2012-121393

Citation: Journal of Alzheimer's Disease, vol. 33, no. 4, pp. 923-928, 2013

Price: EUR 27.50