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Authors: Xu, Heng | Yue, Chengjin | Chen, Lin

Article Type: Research Article

Abstract: Many patients with Alzheimer’s disease suffer from severe neuropathic pain. Soluble guanylate cyclase (sGC) is a critical enzyme of the nitric oxide (NO) signaling pathway. Binding of NO to a group of prosthetic heme on sGC initiates the second messenger cGMP synthesis, resulting in increases in the mechanical threshold for neuropathic pain. Nevertheless, the regulation of sGC remains unclear. Here, we aimed to figure out a strategy to reduce sGC levels by microRNA (miRNA) intervention. Bioinformatical studies were then performed to predict sGC-targeting miRNAs; additionally, an assay of dual luciferase reporter was used for evaluating the functional binding of miRNAs …to sGC. Among all sGC-targeting miRNAs, in particularly we found that miR-142-5p markedly inhibited sGC protein translation by pairing to the 3’-UTR of the sGC mRNA. Orthotopic injection of adeno-associated virus carrying miR-142-5p significantly decreased sGC and sGMP levels, resulting in reduction of the neuropathic pain in rats with the left hind leg sciatic nerve injured in the tibia and peroneal branches. In summary, these data show that miR-142-5p induction in injured neurons may be an effective treatment for neuropathic pain and worthy of further investigation as a treatment for those patients with Alzheimer’s disease and neuropathic pain. Show more

Keywords: Alzheimer’s disease, miR-142-5p, neuropathic pain, nitric oxide, soluble guanylate cyclase

DOI: 10.3233/JAD-190743

Citation: Journal of Alzheimer's Disease, vol. 71, no. 4, pp. 1331-1338, 2019

Authors: Chen, Lin | Peng, Jin | Rao, Congjun | Rosyida, Isnaini

Article Type: Research Article

Abstract: With the increasing of the complexity of a system, there is a variety of indeterminacy in the practical applications of graph theory. We focus on uncertain random graph, in which some edges exist with degrees in probability measure and others exist with degrees in uncertain measure. In this paper, the chance theory is applied to construct the cycle index of an uncertain random graph. Then a method to calculate the cycle index of an uncertain random graph is presented. We also discuss some properties of the cycle index.

Keywords: Cycle index, uncertain random graph, chance theory, uncertainty theory

DOI: 10.3233/JIFS-17373

Citation: Journal of Intelligent & Fuzzy Systems, vol. 34, no. 6, pp. 4249-4259, 2018

Authors: CHEN, Lin | ZHOU, Ming-hua | LEI, Le-cheng

Article Type: Research Article

Abstract: This paper provides evidence for the degradation of organic pollutant by the photo-Fenton complex mechanism. Both the complex oxidation and HO· oxidation mechanisms were verified by p-chlorophenol degradation, UV/Vis spectra anaylsis, and quantum yield. The hydroxyl radical involved in the photo-Fenton process can also be generated from the decomposition of H_2 O_2 , photolysis of Fe^{3+} and degradation of hydrated Fe(VI)-complex, excepting the traditional Fenton reaction.

Keywords: photo-Fenton, p-chlorophenol, mechanism

Citation: Journal of Environmental Sciences, vol. 18, no. 2, pp. 388-391, 2006

Authors: Ma, Yinjin | Zhang, Yajuan | Chen, Lin | Jiang, Qiang | Wei, Biao

Article Type: Research Article

Abstract: BACKGROUND: Chest CT scan is an effective way to detect and diagnose COVID-19 infection. However, features of COVID-19 infection in chest CT images are very complex and heterogeneous, which make segmentation of COVID-19 lesions from CT images quite challenging. OBJECTIVE: To overcome this challenge, this study proposes and tests an end-to-end deep learning method called dual attention fusion UNet (DAF-UNet). METHODS: The proposed DAF-UNet improves the typical UNet into an advanced architecture. The dense-connected convolution is adopted to replace the convolution operation. The mixture of average-pooling and max-pooling acts as the down-sampling in the encoder. Bridge-connected layers, including convolution, batch …normalization, and leaky rectified linear unit (leaky ReLU) activation, serve as the skip connections between the encoder and decoder to bridge the semantic gap differences. A multiscale pyramid pooling module acts as the bottleneck to fit the features of COVID-19 lesion with complexity. Furthermore, dual attention feature (DAF) fusion containing channel and position attentions followed the improved UNet to learn the long-dependency contextual features of COVID-19 and further enhance the capacity of the proposed DAF-UNet. The proposed model is first pre-trained on the pseudo label dataset (generated by Inf-Net) containing many samples, then fine-tuned on the standard annotation dataset (provided by the Italian Society of Medical and Interventional Radiology) with high-quality but limited samples to improve performance of COVID-19 lesion segmentation on chest CT images. RESULTS: The Dice coefficient and Sensitivity are 0.778 and 0.798 respectively. The proposed DAF-UNet has higher scores than the popular models (Att-UNet, Dense-UNet, Inf-Net, COPLE-Net) tested using the same dataset as our model. CONCLUSION: The study demonstrates that the proposed DAF-UNet achieves superior performance for precisely segmenting COVID-19 lesions from chest CT scans compared with the state-of-the-art approaches. Thus, the DAF-UNet has promising potential for assisting COVID-19 disease screening and detection. Show more

Keywords: Coronavirus disease 2019 (COVID-19), computed tomography (CT), deep learning, dual attention, medical image segmentation

DOI: 10.3233/XST-230001

Citation: Journal of X-Ray Science and Technology, vol. 31, no. 4, pp. 713-729, 2023

Authors: Zhang, Zhi-Hao | Wang, Jie-Sheng | Chen, Lin

Article Type: Research Article

Abstract: This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433 .

DOI: 10.3233/JIFS-233769

Citation: Journal of Intelligent & Fuzzy Systems, vol. 46, no. 1, pp. 2665-2691, 2024

Authors: Sun, Zong-Qiong | Ge, Yu-Xi | Chen, Lin | Li, Jie | Jin, Lin-Fang | Xie, Zhi-Hui

Article Type: Research Article

Abstract: PURPOSE: To investigate feasibility of applying low-dose CT perfusion imaging (CTPI) to diagnose gastric cancer. MATERIALS AND METHODS: Twenty patients with gastric cancer confirmed by endoscopic biopsy were undergone routine dose (120 kV, 100 mA) and low-dose (120 kV, 50 mA) CTPI examination, respectively. The original data were processed by body perfusion software, and the perfusion parameters values including blood flow (BF), blood volume (BV) and permeability surface (PS) of gastric cancer were measured. Statistical data analyses including paired-samples t test, Pearson correlation analysis and Bland-Altman consistency test were used to compare the perfusion parameters values between the routine dose and low-dose CTPI examinations. …Radiation dosage, which the patients received during two CTPI examinations, was also calculated and compared. RESULTS: There were no statistical differences in the BF, BV and PS values between routine dose group and low-dose group (P  > 0.05), and there were significant correlation in the BF, BV and PS values between two groups (P  <  0.01). The consistency of BF and BV values between the two groups was preferable to that of PS value. The radiation dosage of the low-dose group was much less than that of routine dose group, and the CTDIvol and DLP values of low-dose CTPI were decreased by 50%, respectively. CONCLUSION: The parameters BF and BV values may play a valuable role in the diagnosis and assessment of gastric cancer in low-dose CTPI examination. Show more

Keywords: Low-dose, computed tomography, perfusion imaging, gastric cancer

DOI: 10.3233/XST-17282

Citation: Journal of X-Ray Science and Technology, vol. 25, no. 5, pp. 847-855, 2017

Authors: Yang, Xiao-Hui | Huang, Han-Chang | Chen, Lin | Xu, Wei | Jiang, Zhao-Feng

Article Type: Research Article

Abstract: Cu(II) has been shown in vitro to profoundly promote the aggregation of amyloid-β peptide (Aβ, a key pathological event in Alzheimer's disease. We investigated both the effect of Cu(II) on the secondary structure transformation of Aβ and the probable residues involved in the chelation to Cu(II). The effects of Cu(II) on Aβ was analyzed by the circular dichroism spectra, Th-T fluorescence and sedimentation assay, and the results indicated that Cu(II) could disrupt the already formed β-sheet structure, convert β-sheeted aggregates into non-β-sheeted aggregates and promote oligomeric Aβ to precipitate in a non-β-sheeted aggregation way. Additionally, we confirmed that the function …of Cu(II) discussed above was achieved through its interaction with His6, His13, and His14 by investigating an Aβ mutant, 23,6,13,14 Aβ1-40 . Show more

Keywords: Alzheimer's disease, amyloid-β peptide, β-sheet structure, copper

DOI: 10.3233/JAD-2009-1186

Citation: Journal of Alzheimer's Disease, vol. 18, no. 4, pp. 799-810, 2009

Authors: Liu, Lingling | Chen, Lin | Zhao, Caihan | Fan, Ruifang | Tang, Qing | Yuan, Qing | Du, Wei | Liu, Xiangfu

Article Type: Research Article

Abstract: INTRODUCTION: This study retrospectively analyzed a total of 86 leukapheresis treatments in 55 patients with hyperleukocytic leukemia (HLL). METHODS: In the leukapheresis treatments, the monitoring collection (MNC) program in COBE spectra continuous flow centrifuge (CFC) for blood component separator was used. RESULTS: In this study, the white blood cell (WBC) suspension volume collected in leukapheresis treatment were 870.72±208.40 mL, and significantly larger than that reported in previous study. Compared with before leukapheresis, there were no difference in patient with HLL on the peripheral blood platelet (PLT) count and hemoglobin (HGB) levels. The index plasma fibrinogen (FIB) concentration was slightly reduced by …leukapheresis, however, it did not affect a lot the maintenance of normal hemostatic function in patients with HLL. DISCUSSION: Our data provided evidences that large-volume leukapheresis had no obvious effects on HGB level and coagulation functions in patient with HLL. So large-volume leukapheresis by CFC could be widely used in clinic. Show more

Keywords: Leukapheresis, hemoglobin, platelet, coagulation, hyperleukocytic leukemia

DOI: 10.3233/CH-231737

Citation: Clinical Hemorheology and Microcirculation, vol. 84, no. 3, pp. 275-281, 2023

Authors: Johansen, Michelle C. | Wang, Wendy | Zhang, Michael J. | Alonso, Alvaro | Wong, Dean F. | Gottesman, Rebecca F. | Chen, Lin Y.

Article Type: Short Communication

Abstract: The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (> 1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

Keywords: Arrhythmias, atrial fibrillation, cognitive impairment, imaging

DOI: 10.3233/JAD-215378

Citation: Journal of Alzheimer's Disease, vol. 86, no. 1, pp. 43-48, 2022

Authors: Yang, Hai-Ping | Chen, Yue-Ling | Liu, Zong-Jian | Hao, Yi | Chen, Lin | Zhang, Zhen-Hua | He, Ning | Wang, Jing

Article Type: Research Article

Abstract: BACKGROUND: Circular RNAs (circRNAs) are a new class of noncoding RNAs, which interfere with gene transcription by absorbing microRNAs (miRNAs). OBJECTIVE: The expression profile and roles of circRNAs in unstable angina (UA) patients remains unclear. METHODS: An initial screening of circRNA expression by microarray analysis was performed using blood samples from three pairs of UA patients and matched healthy individuals. The differential expression of the chosen six circRNAs from the results of the microarray analysis was validated by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: The microarray results demonstrated that some circRNAs were markedly different in UA patients, when compared …with matched healthy individuals. In these UA patients, 22 circRNAs were upregulated and six circRNAs were downregulated when a P -value of < 0.05 was considered as a cut-off level and the fold change was > 1.5. Among the six circRNAs chosen for further analysis, qRT-PCR identified that five of these were upregulated, and the remaining circRNA was downregulated. By comparing the outcome of the six candidate circRNAs between the circRNAs microarray assay and RT-PCR validation, it was found that four circRNAs (hsa_circ_0002229, hsa_circ_0005580, hsa_circ_0046667, and hsa_circ_0001451) had the same variation trend. CONCLUSION: The present study provided the expression profile of circRNAs in UA patients. Moreover, some circRNAs have the potential to be biomarkers for the detection of UA patients. Further studies with a larger population will focus on hsa_circ_0002229, hsa_circ_0005580, hsa_circ_0046667 and hsa_circ_0001451. Show more

Keywords: Unstable angina, circular RNAs, expression profile, biomarkers

DOI: 10.3233/THC-220131

Citation: Technology and Health Care, vol. 31, no. 2, pp. 497-505, 2023