Authors: Lu, Haibing | Hong, Yuan | Yang, Yanjiang | Duan, Lian | Badar, Nazia
Article Type: Research Article
Abstract: Role mining is to define a role set to implement the role-based access control (RBAC) system and regarded as one of the most important and costliest implementation phases. While various role mining models have been proposed, we find that user experience/perception – one ultimate goal for any information system – is surprisingly ignored by the existing works. One advantage of RBAC is to support multiple role assignments and allow a user to activate the necessary role to perform the tasks at each session. However, frequent role activating and deactivating can be a tendinous thing from the user perspective. A user-friendly …RBAC system is expected to assign few roles to every user. So in this paper we propose to incorporate to the role mining process a user-role assignment constraint that mandates the maximum number of roles each user can have. Under this rationale, we formulate user-oriented role mining as the user role mining problem, where all users have the same maximal role assignments, the personalized role mining problem, where users can have different maximal role assignments, and the approximate versions of the two problems, which tolerate a certain amount of deviation from the complete reconstruction. The extra constraint on the maximal role assignments poses a great challenge to role mining, which in general is already a hard problem. We examine some typical existing role mining methods to see their applicability to our problems. In light of their insufficiency, we present a new algorithm, which is based on a novel dynamic candidate role generation strategy, tailored to our problems. Experiments on benchmark data sets demonstrate the effectiveness of our proposed algorithm. Show more
Keywords: Role-based access control, role mining, user-oriented, optimization, heuristic algorithm
DOI: 10.3233/JCS-140519
Citation: Journal of Computer Security, vol. 23, no. 1, pp. 107-129, 2015
Authors: Duan, Lian | Qian, Xueshen | Wang, Qin | Huang, Lan | Ge, Song
Article Type: Research Article
Abstract: Background: With advancements in periodontal medicine, the relationship between periodontitis and systemic diseases has garnered increasing attention. Recently, emerging evidence has indicated that periodontitis may be involved in the pathogenesis of Alzheimer’s disease (AD). Objective: To assess the impact of experimental periodontitis on cognitive function deficits in a rat model of streptozotocin-induced AD and determine the mechanisms underlying these effects. Methods: Rats were randomly assigned to the control (C), experimental periodontitis (P), Alzheimer’s disease (AD), and experimental periodontitis with streptozotocin-induced AD (AD-P) groups. Experimental periodontitis was induced using ligation and coating with Porphyromonas gingivalis . In the AD-P group, AD …was induced by intracerebroventricular injection of streptozotocin after 6 weeks of experimental periodontitis induction. Results: Compared with the group C rats, those in group P exhibited alveolar bone resorption, learning and memory function impairment, and decreased insulin sensitivity and insulin signaling-related protein expression. Glial cell activation and cognitive impairment in streptozotocin-induced groups with significantly increased phosphorylated tau levels were more pronounced relative to the C group. The number of neurons and insulin sensitivity and insulin signaling-related protein expression in group AD-P rats were lower than those in the AD alone group, while the expressions of glial fibrillary acidic protein, tau phosphorylation, interleukin-6, and cyclooxygenase-2 were significantly increased. Conclusion: Periodontitis may be a risk factor exacerbating cognitive deficits in an AD-like neurodegenerative context, possibly by impairing the insulin signaling pathway and stimulating gliosis and neuroinflammation. Show more
Keywords: Alzheimer’s disease, insulin sensitivity, insulin signaling pathway, periodontitis, streptozotocin
DOI: 10.3233/JAD-215720
Citation: Journal of Alzheimer's Disease, vol. 88, no. 1, pp. 57-74, 2022
Authors: Duan, Lian | Dang, Guangfu | Ge, Jinling | Gao, Yang | Wang, Lihua
Article Type: Research Article
Abstract: BACKGROUND: Aspheric intraocular lens (IOLs) implantation has been widely applied in cataract surgery. However, there is no consensus on the optimal guidance for the operations in IOLs implantation. OBJECTIVE: This study evaluated the visual function of Chinese cataract patients six months after cataract surgery with two different guiding ideologies. METHODS: We evaluated 50 patients (61 eyes) with implantation of different aspheric IOLs (SN60WF IOLs, ZCB00 IOLs, PY-60AD IOLs, AO IOLs) 6 months after cataract surgery. Twenty-four patients (30 eyes) under individual implantation were ascribed to group 1 and 26 patients (31 eyes) with randomized implantation were ascribed to the control …group (group 2). Postoperatively parameters included monocular best-corrected visual acuity (BCVA), contrast sensitivity (CS), total spherical aberration Z (4, 0) at 5 mm pupil size, and patient satisfaction. The quality of life after operation was assessed through the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). RESULTS: Six months after cataract operation, the contrast sensitivity with glare of group 1 at 2.5 ∘ was 0.697 ± 0.027, and 0.532 ± 0.049 in group 2. Besides, there was no significant difference at any other special frequency. The mean spherical aberration Z (4, 0) at 5 mm pupil size in group 1 was 0.015 ± 0.028 um, and in group 2 was 0.043 ± 0.109 um, with a significant difference (p < 0.01). The mean scores obtained from NEI VFQ-25 were not significantly different. CONCLUSION: It is effective to implant aspheric IOLs individually according to preoperative corneal spherical aberration. Patients obtained better contrast sensitivity with glare at 2.5 ∘ , but there was no significant difference in BCVA, contrast sensitivity at other special frequency, and subjective visual function. Show more
Keywords: Visual function, cataract, aspheric intraocular lens implantation, best-corrected visual acuity, contrast sensitivity
DOI: 10.3233/THC-220154
Citation: Technology and Health Care, vol. 31, no. 3, pp. 831-839, 2023
Authors: Qian, Xueshen | Zhang, Shuang | Duan, Lian | Yang, Fengchun | Zhang, Kun | Yan, Fuhua | Ge, Song
Article Type: Research Article
Abstract: Background: Although periodontitis is reportedly associated with increased cognitive decline in Alzheimer’s disease, the mechanisms underlying this process remain unknown. Porphyromonas gingivalis lipopolysaccharide (P.g-LPS) is an endotoxin associated with periodontal disease. Objective: We investigated the effect of periodontitis on learning capacity and memory of amyloid-β protein precursor (AβPP)/presenilin (PS1) transgenic mice along with the mechanisms underlying these effects. Methods: Mice were randomly assigned to three groups, namely AβPP/PS1 (control), P.g-LPS Injection, and P.g-LPS Injection + Ligation. Mice from the P.g-LPS Injection group were injected with P.g-LPS in the periodontal tissue three times per week for 8 weeks, while mice from the P.g-LPS …Injection + Ligation group were injected with P.g-LPS and subjected to ligation of the gingival sulcus of the maxillary second molar. Results: Expression of gingival proinflammatory cytokines as well as alveolar bone resorption in P.g-LPS-injected and ligatured mice was increased compared to that in control mice. Mice in the P.g-LPS Injection + Ligation group exhibited cognitive impairment and a significant reduction in the number of neurons. Glial cell activation in the experimental groups with significantly increased amyloid-β (Aβ) levels was more pronounced relative to the control group. Induction of periodontitis was concurrent with an increase in cyclooxygenase-2, inducible nitric oxide synthase, AβPP, and beta-secretase 1 expression and a decrease in A disintegrin and metalloproteinase domain-containing protein 10 expression. Conclusion: These findings indicated that periodontitis exacerbated learning and memory impairment in AβPP/PS1 mice and augmented Aβ and neuroinflammatory responses. Our study provides a theoretical basis for risk prediction and early intervention of Alzheimer’s disease and periodontitis. Show more
Keywords: Alzheimer’s disease, cognitive dysfunction, lipopolysaccharide, periodontitis, Porphyromonas gingivalis
DOI: 10.3233/JAD-201007
Citation: Journal of Alzheimer's Disease, vol. 79, no. 4, pp. 1785-1800, 2021
Authors: Zhang, Zhihua | Sheng, Hongxia | Liao, Li | Xu, Chen | Zhang, Ang | Yang, Yang | Zhao, Long | Duan, Lian | Chen, Hu | Zhang, Bin
Article Type: Research Article
Abstract: Background: Mesenchymal stem cells-conditioned medium (MSC-CM) provides a promising cell-free therapy for Alzheimer’s disease (AD) mainly due to the paracrine of MSCs, but the precise mechanisms remain unclear. Studies suggests that mitochondrial dysfunction precedes the accumulation of amyloid-β plaques and neurofibrillary tangles, and involves in the onset and development of AD. Objective: In the present study, we evaluated the protective effects and explored the related-mitochondrial mechanisms of human umbilical cord derived MSC-CM (hucMSC-CM) in an AD model in vitro . Methods: To this end, an AD cellular model was firstly established by okadaic acid (OA)-treated SH-SY5Y cells, and then treated …by hucMSC-CM to assess the oxidative stress, mitochondrial function, apoptosis, AD-related genes, and signaling pathways. Results: hucMSC-CM significantly deceased tau phosphorylated at Thr181 (p181 -tau) level, which was increased in AD. hucMSC-CM also alleviated intracellular and mitochondrial oxidative stress in OA-treated SH-SY5Y cells. In addition, hucMSC-CM suppressed apoptosis and improved mitochondrial function in OA-treated SH-SY5Y cells. Flow cytometric analysis indicated that hucMSC-CM exerted the protective effects relying on or partly extracellular vesicle (EV) mitochondrial transfer from hucMSCs to OA-treated SH-SY5Y cells. Moreover, RNA sequencing data further demonstrated that hucMSC-CM regulated many AD-related genes, signaling pathways and mitochondrial function. Conclusion: These results indicated that MSC-CM or MSC-EVs containing abundant mitochondria may provide a novel potential therapeutic approach for AD. Show more
Keywords: Alzheimer’s disease, apoptosis, mesenchymal stem cell-conditioned medium, mitochondrial dysfunction, mitochondrial transfer
DOI: 10.3233/JAD-200686
Citation: Journal of Alzheimer's Disease, vol. 78, no. 3, pp. 1161-1176, 2020